A family member admitted to the hospital for IV antibiotics just told me the RN took "2 hot sauce bottles of blood" which is how i will be referring to blood cultures from now on.

¡Muy emocionado de compartir nuestro más reciente artículo publicado en Blood! 🎉En este hilo, @corynnkasap resume de manera excelente en inglés los hallazgos principales en un tweetorial. Hoy quiero compartirlos en español 👇 https://t.co/x7cuQjZ0kh

@UCSF We are excited about the potential for anti-CD70 CAR-Ts to make a difference for for high-risk #myeloma patients

Special shout-out to our Junior Specialist Sanjana Prudhvi, who designed our Visual Abstract. We are lucky to work with such an amazing team, including everyone in the Wiita Lab @UCSF and our collaborators. (10/10)

Finally, we developed a proof-of-principle dual-targeting CAR against both BCMA and CD70 as a potential strategy to avoid antigen escape–mediated resistance in #HRMM (9/10)

We also evaluated epigenetic regulation of CD70 in #myeloma, using a machine learning model to predict and then test key transcriptional regulators of surface expression (8/10)

While all anti-CD70 CARs demonstrated clear efficacy against myeloma cell line xenograft models in vivo, the CD27-based CAR showed remarkable >80-fold expansion‼️ versus scFv-based CARs, suggesting a highly favorable phenotype for clinical translation (7/10)

We then used the crystal structure of CD70 bound to its natural receptor CD27 to develop a structure-guided, optimized CD27-based CAR to compare to standard “scFv” based CAR, using frameworks containing either CD28 or 4-1BB costim domains. (6/10)

Analysis of paired tumor RNA sequencing data from @theMMRF CoMMpass study, cell surface #proteomics, and flow cytometry revealed CD70 was present on primary #myeloma. CD70 transcript was strongly enriched in high risk genotypes t(4;14), gain 1q, and loss 1p (5/10)

Major support from Myeloma Solutions Fund, NIH NCI, and @UCSF Living Therapeutics Initiative (4/10)

This work was co-led by myself, Adila Izgutdina, and @bonellpatinoe under mentorship of @apwiita, + collab w/ @biobenbarwick, Larry Boise @EmoryUniversity, @jdlicht, @shanmugamlab, @KortemmeLab, Samir Parekh at @IcahnMountSinai, Stieglitz lab and the myeloma clinical group @UCSF.

In this work we show CD70 is a novel CAR target enriched in #HRMM. We used structure-guided design to optimize a CD27-based anti-CD70 CAR-T that outperforms scFv-based CAR-Ts in preclinical efficacy studies. (2/10)

Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) https://t.co/dR6jXxUxUa

🎶 Love deep music and culture writing? Support my work on Patreon and help sustain independent journalism. Every bit counts 👉 https://t.co/jhFqpu4a2Z #SupportIndependentWriters #MusicCriticism

An important perspective on the negative impact of the federal funding cuts and pauses on early career physician scientists:

When women scientists connect and lead, the whole field moves forward. @UCSFPath's Carolyn Sangokoya saw a gap and built @MDPhDEquity to change that. Through mentorship and collaboration, she’s creating a stronger future for women in science. https://t.co/clxmuEq7D1

Great, raucous gathering for #StandUpForScience in San Francisco!

Beautiful day and amazing turnout to hear keynote speaker and Nobel laureate Carolyn Bertozzi speak in San Francisco at today’s protest in defense of federal science funding #StandUpForScience2025 #StandUpForScience

Joined fellow scientists and science enthusiasts at #StandUpForScience in Ohio sporting my Science Rules shirt! 💪🧬🔬

Thank you for coming to my poster #StandUpForScience

Amazing turnout at today’s #StandUpForScience in San Francisco