Chris Mutti
@chrismutti1
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Joined October 2013
Congrats to @chrismutti1 on publishing his PhD research on mitoribosome assembly! This builds upon @LindseyVanHaute's work on the methyltransferase METTL15, revealing that its catalytic activity is not essential for mtSSU biogenesis. https://t.co/fexZAMz5UU
@MBU_postdocs @MRC_MBU
tandfonline.com
Ribosomes are large macromolecular complexes composed of both proteins and RNA, that require a plethora of factors and post-transcriptional modifications for their biogenesis. In human mitochondria...
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A library of base editors for the precise ablation of all protein-coding genes in the mouse mitochondrial genome https://t.co/k7lTR5WPln
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Today @PedroSiPinheiro etal. present in @natBME a library of base editors #MitoKO to ablate all protein-coding genes in mouse mtDNA. #MitoKO will help generating new, clinically meaningful models for mechanistic, drug discovery and pre-clinical studies https://t.co/DkMWEZth1w 1/8
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This work was a terrific @mito_gene team effort spearheaded by @PedroSiPinheiro and tremendous contributions from @chrismutti1 @LindseyVanHaute Chris Powell, Pavel Nash & @KeiraT_ Congratulations!!! 🍾🎉🥳 8/8
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Read about recent advances and developments in genetic engineering of mitochondrial DNA and what this means for future treatment of diseases https://t.co/9vHGdalkk5
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The @MRC_MBU @Mito_at_GU & @MolMet_KI spin-out company https://t.co/7QevismRF4 launched officially today with $72.5M Series A financing🥨🚀 Looking forward to Pretzel's future work on treatments for diseases in which mitochondrial dysfunction plays a role https://t.co/uw98oCYkvy
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Online Now: The human mitochondrial genome contains a second light strand promoter
cell.com
Mitochondrial DNA replication primers and light strand gene products were both thought to arise via transcription from a single promoter (LSP) in humans for over 40 years. Tan et al. report the...
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Pleasure to contribute to this pioneering study - congrats to @Mito_at_GU @mustloveDNA
We discovered and characterised a second light strand promoter (LSP2) on the human mitochondrial genome that was undetected for over 40 years. Welcome to the family, LSP2. Thanks to @Mito_at_GU and collaborators @ChinneryPatrick @NCL_mtDNA
@mito_gene
https://t.co/rxvXGOftRc
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Treatment for mitochondrial diseases has the potential to be aided by recent developments in mitochondrial genome engineering. https://t.co/WGpHNE5Omd
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Happy to contribute to this article in @The_Biochemist, please check it out!
Please check out our latest @The_Biochemist mini-review on genetic engineering of the mitochondrial genome | @chrismutti1 @PedroSiPinheiro @MBU_postdocs @MRC_MBU Fixing the powerhouse: genetic engineering of mitochondrial DNA
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Errors in the DNA of our #mitochondria – the batteries that power our cells – cause devastating diseases. Researchers @MRC_MBU have shown in mice that it may be possible to correct these errors using gene-editing: https://t.co/CBcpcmQAhn
@The_MRC @4Lilyfoundation @TheChampFound
cam.ac.uk
Our cells contain mitochondria, which provide the energy for our cells to function. Each of these mitochondria contains a tiny amount of mitochondrial DNA. Mitochondrial DNA makes up only 0.1% of the
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Today @PedroSiPinheiro etal. report on the in vivo use of mito DNA base editing #DdCBE to install a novel #mtDNA mutation in the heart of adult and neonatal mice. This PoC that could lead to future therapies for #MitoDisease @natcomms @MRC_MBU @chrismutti1
nature.com
Nature Communications - Mutations in mitochondrial DNA can lead to clinically heterogeneous disease. Here the authors demonstrate in vivo base editing of mouse mitochondrial DNA in a post-mitotic...
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Congrats to Eva Schöller,@MarchandVirgin3 @chrismutti1 C.Powell & many more! @MolecularCell The role of METTL8/m3C in mito. translation https://t.co/S6YvyQ8Ehz A great collaboration with G.Meister lab @uni_regensburg @AttheHelm3 @MarkusHafner4 et al. THX for getting us involved!
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Excited to share this new paper from the lab: a novel factor involved in building up the mitochondrial ribosome | Spearheaded by @aarondioxide /@AaronRDSouza1+@chrismutti1 @GuiomarPedro et al. | Thanks for perseverance! @NAR_Open
https://t.co/dyxNKIzmJw
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With our colleagues from Italy we describe how a genetic change in a gene coding for a componant of mitoribosome leads to #mitochondrialdisease | very 1st paper of our PhD student @chrismutti1 - Congrats! @Erikafvb @MRC_MBU @bambinogesu @NeuroBesta
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