Changya
@Changya1
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Joined August 2014
Excited to share the first spatially resolved multiomics atlas for human bone marrow, published today in @CellCellPress. https://t.co/EVT4qrhiFs. Wonderful collaborations with Ling Qin @LingQin6, Charles Nelson, Martin Carroll, Ivan Maillard, Vinohd Pillai @pillai_vinodh labs!
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Excited to announce deMULTIplex2 - a powerful new classification algorithm for multiplexed scRNA-seq data from the Gartner lab and @czbiohub, @c3STC, and @UCSF developed by @QinZhu_1 & @Danny__Conrad: https://t.co/pOlRppyLki
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Great presentation @ASH_hematology by another lab member, Changya Chen @Changya1 on characterization of progenitor-like blasts in high risk leukemias! Great collaboration with David Teachey, @kathrinbernt, Sarah Tasiah, @Junjyang labs! #ASH22
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Thanks for your nice review!
Check out our review of the single-cell multiomics work done by @KaiTanLab1 on KMT2Ar leukemia. It's great to see progress on improving outcomes in pediatric cancers! https://t.co/59YYDJWBHX
@vangalenlab @cdktmw @Changya1 @wbaopaul
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Happy to share our newest study on KMT2Ar leukemia using single cell multiomics! https://t.co/TxsJ4p7dfU
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Just published #OnlineFirst: Integrative bulk and #singlecell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of #CARTcell therapy. @cdktmw @UPennGCB @ChildrensPhila #immunotherapy
https://t.co/lA5Ct1vRY5
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Excited to share our single-cell multi-omics study of a high-risk subtype of leukemia, as part of the @NCIHTAN. Tremendous effort by multiple labs at @CHOPCancerCntr, @penngenetics, @pennpathlabmed, @childrensmercy, @HopkinsKids. @bioRxiv viewer
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So excited to share our preprint about infant leukemia study at single-cell resolution!
Excited to share our single-cell multi-omics study of a high-risk subtype of leukemia, as part of the @NCIHTAN. Tremendous effort by multiple labs at @CHOPCancerCntr, @penngenetics, @pennpathlabmed, @childrensmercy, @HopkinsKids. @bioRxiv viewer
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Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers
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Great collaboration with the Speck lab.
In this study Gao et al., performed RNA-Seq and histone mark ChIP-Seq to define the transcriptomes and epigenomes representing key developmental stages of HSC ontogeny. @ChildrensPhila @KaiTanLab1 @cdktmw @LabSpeck @penggao8 @Changya1 @howell_ED2
https://t.co/lwyiYHBm2f
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Excited to share our new method MAPLE for integrating single-cell methylome and transcriptome data based on supervised learning.
biorxiv.org
Despite rapid advances in single-cell DNA methylation profiling methods, computational tools for data analysis are lagging far behind. A number of tasks, including cell type calling and integration...
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Our latest puplication is online! The work was a collaboration with @KaiTanLab1 (@cdktmw) with @penggao8, @Changya1, and our graduate student @howell_ED2 leading the work -
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Very proud of our study. Technically very challenging experiments to do, dealing with rare primary hematopoietic stem cells. Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells: Cell Reports
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Very excited to share the joint work with the Speck lab to map the transcriptional regulatory circuitry during definitive embryonic hematopoiesis. Kudos to Peng, Changya and Elizabeth from both labs who did the lion's share of the work! https://t.co/U8Tu0F18OX
biorxiv.org
Hematopoietic stem cell (HSC) ontogeny is accompanied by dynamic changes in gene regulatory networks. We performed RNA-Seq and histone mark ChIP-Seq to define the transcriptomes and epigenomes of...
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Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells
biorxiv.org
Hematopoietic stem cell (HSC) ontogeny is accompanied by dynamic changes in gene regulatory networks. We performed RNA-Seq and histone mark ChIP-Seq to define the transcriptomes and epigenomes of...
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Very excited to share our new preprint on pre-HSC formation in early development. Feedbacks are welcome! It's a two-years-long effort with Tan Lab (@cdktmw) and Speck Lab to collect and dig into the scRNA and scATAC data and functionally validate our findings!
Developmental trajectory of pre-hematopoietic stem cell formation fromendothelium https://t.co/SZFBOLsWC5
#bioRxiv
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scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data
biorxiv.org
Single cell chromatin accessibility sequencing (scCAS) has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. The development of several experimental protoc...
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scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data
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Spatial genome re-organization between fetal and adult hematopoietic stem cells
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