Joshua Meier
@joshim5
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Co-Founder at Chai Discovery
San Francisco
Joined March 2009
Our latest results show AI-generated antibodies with *drug-like* properties. It's honestly so cool to release this... AI is moving so fast. It feels like models improve in real-time @chaidiscovery. These kind of breakthroughs used to take years… now we get each in months 🚀
Today, we’re releasing new data showing that Chai-2 can design antibodies against challenging targets with atomic precision. >86% of our designs possess industry-standard drug-quality properties without any optimization. Thread👇
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.@chaidiscovery raised a Series B just three months after their Series A, and we co-led it. GC's Elena Viboch recently joined @Bloomberg's @CarolineHydeTV alongside Chai Discovery co-founder @joshim5 to discuss our life sciences investment strategy and the breakthrough
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I've always believed AI would transform drug discovery, but I never imagined we'd see its impact this quickly. Working alongside the @chaidiscovery team has been the privilege of a lifetime. Thrilled to welcome @generalcatalyst and @oakhcft as our newest partners.
We raised $130M in Series B funding at a $1.3B valuation to build the computer aided design suite for molecules. The round was led by @GeneralCatalyst & @OakHCFT along with existing investors @ThriveCapital, @OpenAI, @_DimensionCap, @Neo, @lachygroom, @MenloVentures, @svangel,
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When people see big technical wins, they often ask, “Who built that?” At Chai, the honest answer is: everyone. There’s no lone genius behind any project. Every person on the team is a core contributor, and the work is better because of it. That’s the part of Chai I’m most proud
"Would you ever be open to a full time role?" That was the question @jackdent posed to me back in August. Normally, my immediate answer was "Nope." This time, it took five days for me to reply with a "Maybe" that turned into a definitely "Yes!" After spending ten years helping
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Our new whitepaper from @chaidiscovery is now on @biorxivpreprint
Drug-like antibody design against challenging targets with atomic precision 1. The Chai-2 platform has achieved a significant milestone in computational antibody design, demonstrating the ability to design full-length monoclonal antibodies (mAbs) with high success rates and
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I'll be at NeurIPS and MLSB this week in San Diego. DM me if you want to meet up and chat AI x Bio! 🎉
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Today, we’re releasing new data showing that Chai-2 can design antibodies against challenging targets with atomic precision. >86% of our designs possess industry-standard drug-quality properties without any optimization. Thread👇
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This recognition reflects our relentless focus on transforming biology from science into engineering. There’s no reason to believe capabilities should plateau here. We’re excited to keep pushing the boundaries of biotech + AI.
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🚀 Chai Discovery has been named to the 2025 #Endpoints11 list of the most promising companies in biotech! In just 12 months since our first funding round, we’ve raised $100M and launched Chai-2 — our AI model that can design antibodies with double-digit success rates.
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Why now? Chai-2 achieves a ~20% success rate in antibody design. That's 100x better than prior methods. We’re excited to deploy this technology toward the hardest problems. Together, we can discover hundreds more molecules, unlocking a new generation of therapeutics. 🚀
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🧬 Dr. Mikael Dolsten is joining the @ChaiDiscovery board! In 15 years as @Pfizer's Chief Scientific Officer he: ⚛️ Progressed 150 molecules to clinical trials 💊 Delivered 36 approved medicines, from vaccines to cancer therapies
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Find out more about the evolution of Chai-1 to Chai-2, the 200x leap in antibody design success rates, and what this means for drug discovery. Great AI podcast with @JacobEffron of @Redpoint, hosting our co-founder @joshim5 of @chaidiscovery.
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🎙️ Fresh off our $70M Series A at @ChaiDiscovery, it was fun sitting down with @JacobEffron of @Redpoint to discuss Chai-2 and our recent breakthroughs in AI Drug Discovery.
New Unsupervised Learning with @joshim5 (@chaidiscovery) on how AI x drug discovery is starting to inflect and: - The 3 waves of AI biotech - How AI models think differently than chemists - Building "Photoshop for molecules" - Deciding what to open source
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Thank you @Nasdaq for the kind words and for lighting up Times Square! 💙 Excited to keep pushing the boundaries of molecular design with AI.
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Great insights from @max_a_schwarzer on the development of @OpenAI’s GPT5. Frontier AI model development is all about getting the details right, across the entire stack — data, model, algorithms, and more We see the same @chaidiscovery
We asked @max_a_schwarzer (Researcher @OpenAI) about post-training improvements in GPT-5: "The thing that is most impressive about GPT-5 is how much getting all of the details right matters." "The team went off and did a deep dive of completely rebuilding the post-training
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Thank you @akashpasricha for having me and @grgyap on the show.
.@grgyap, Partner at @MenloVentures, shares how generative AI is profoundly changing drug discovery: "It offers you the potential to create new molecules that have never been thought of by humans before." "Now you have an opportunity to... make a drug by seeing inside the lock,
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.@grgyap, Partner at @MenloVentures, shares how generative AI is profoundly changing drug discovery: "It offers you the potential to create new molecules that have never been thought of by humans before." "Now you have an opportunity to... make a drug by seeing inside the lock,
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.@chaidiscovery is *the* AI lab transforming end-to-end biological discovery into an engineering problem. investor from the beginning, and a huge believer in @joshim5 @_jackdent @Mattmcpartlon1 @j_boitreaud and team - more flops for the fire
Proud to announce @ChaiDiscovery has raised a $70M Series A from @MenloVentures & Anthology Fund (@AnthropicAI), @ThriveCapital, @OpenAI + others. 🧬 Chai is an applied AI lab building frontier tools for molecular design. This funding will power our new models, coming soon👇
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