Joshua Meier
@joshim5
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Co-Founder at Chai Discovery
San Francisco
Joined March 2009
Proud to announce @ChaiDiscovery has raised a $70M Series A from @MenloVentures & Anthology Fund (@AnthropicAI), @ThriveCapital, @OpenAI + others. 🧬 Chai is an applied AI lab building frontier tools for molecular design. This funding will power our new models, coming soon👇
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Why now? Chai-2 achieves a ~20% success rate in antibody design. That's 100x better than prior methods. We’re excited to deploy this technology toward the hardest problems. Together, we can discover hundreds more molecules, unlocking a new generation of therapeutics. 🚀.
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🧬 Dr. Mikael Dolsten is joining the @ChaiDiscovery board!. In 15 years as @Pfizer's Chief Scientific Officer he:.⚛️ Progressed 150 molecules to clinical trials.💊 Delivered 36 approved medicines, from vaccines to cancer therapies
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RT @chaidiscovery: Find out more about the evolution of Chai-1 to Chai-2, the 200x leap in antibody design success rates, and what this mea….
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🎙️ Fresh off our $70M Series A at @ChaiDiscovery, it was fun sitting down with @JacobEffron of @Redpoint to discuss Chai-2 and our recent breakthroughs in AI Drug Discovery.
New Unsupervised Learning with @joshim5 (@chaidiscovery) on how AI x drug discovery is starting to inflect and: . - The 3 waves of AI biotech. - How AI models think differently than chemists. - Building "Photoshop for molecules" . - Deciding what to open source
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RT @chaidiscovery: Thank you @Nasdaq for the kind words and for lighting up Times Square! 💙. Excited to keep pushing the boundaries of mole….
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Great insights from @max_a_schwarzer on the development of @OpenAI’s GPT5. Frontier AI model development is all about getting the details right, across the entire stack — data, model, algorithms, and more . We see the same @chaidiscovery.
We asked @max_a_schwarzer (Researcher @OpenAI) about post-training improvements in GPT-5:. "The thing that is most impressive about GPT-5 is how much getting all of the details right matters.". "The team went off and did a deep dive of completely rebuilding the post-training
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Thank you @akashpasricha for having me and @grgyap on the show.
.@grgyap, Partner at @MenloVentures, shares how generative AI is profoundly changing drug discovery:. "It offers you the potential to create new molecules that have never been thought of by humans before.". "Now you have an opportunity to. make a drug by seeing inside the lock,
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RT @theinformation: .@grgyap, Partner at @MenloVentures, shares how generative AI is profoundly changing drug discovery:. "It offers you th….
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RT @saranormous: .@chaidiscovery is *the* AI lab transforming end-to-end biological discovery into an engineering problem. investor from….
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Read more from the @FinancialTimes here:
OpenAI-backed Chai raises $70mn for AI-driven drug discovery
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We’re grateful for the support of our Series A investors @MenloVentures @ThriveCapital @OpenAI Yosemite DST @SVAngel Avenir @DCVC @_DimensionCap @Neo @LachyGroom @FEhrsam, and many others. More about our funding:
chaidiscovery.com
Building frontier artificial intelligence to predict and reprogram the interactions between biochemical molecules.
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A meaningful fraction of the biotech industry has already applied for Chai-2 access. We’re excited to bring this technology to our partners. Learn more & apply for early access at
chaidiscovery.com
Building frontier artificial intelligence to predict and reprogram the interactions between biochemical molecules.
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🧬 To help deploy our technology, Dr. Mikael Dolsten is joining the Chai Discovery board. In 15 years as @Pfizer's Chief Scientific Officer he:. ✅Progressed 150 molecules to clinical trials.✅Delivered 36 approved medicines, from vaccines to cancer therapies.
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🧑‍🔬Chai-2 delivers de novo antibody design with a >15% hit rate (vs. 0.1% for previous AI methods). 🏆One group spent 3+ years and $5M on a tough target. With Chai-2 we delivered an experimentally validated binder in just two weeks.
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
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Weeks ago, we launched Chai-2, a major leap forward in molecular design. Chai-2 enables us to design antibodies from scratch, entirely on the computer.
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Chai’s mission is to transform biology from science into engineering to unlock entirely new frontiers in medicine. With Chai-1, we delivered the ability to see the structure of molecules. Now with Chai-2, we have unlocked the ability to design and create them.
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RT @OracleCloud: 🔬 Accelerating scientific breakthroughs with OCI. @chaidiscovery leveraged OCI to support the adv….
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RT @chaidiscovery: 🎉 Congratulations to @ZhuoranQ for winning the Chen Institute and @ScienceMagazine AI Prize, recognizing his groundbreak….
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Chai-2 is now up on BioRxiv:
biorxiv.org
Despite breakthroughs in protein design enabled by artificial intelligence, reliably designing functional antibodies from scratch has remained an elusive challenge. Recent works show promise but...
Zero-shot antibody design in a 24-well plate @chaidiscovery. 1. Researchers have introduced Chai-2, a multimodal generative model that marks a significant leap in de novo antibody and miniprotein design. This platform achieves an impressive 16% hit rate in de novo antibody
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