Carlo M. Cicala
@carlomcicala
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MD | Medical Oncologist | Sarcoma Translational Research @vhio | Doctoral Fellow @uabbarcelona | Soft spots: hiking, Russian books, long breakfasts.
Barcelona, Spain
Joined January 2022
Happy to share our work on #NGS findings in SDH-deficient #GISTs. Thanks to all the coauthors and to @JCOPO_ASCO for publishing our work. @quindos_maria @Genomicslab_ @DrCeSarcoma @dgomezpere @steland011 @Serrano_Lab @VHIO
https://t.co/QS1YSLXIgB
ascopubs.org
PURPOSELess than 5% of GI stromal tumors (GISTs) are driven by the loss of the succinate dehydrogenase (SDH) complex, resulting in a pervasive DNA hypermethylation pattern that leads to unique...
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Dr Kasper on the current landscape of treatment for #desmoid tumors: 🔸only sorafenib and nirogacestat are supported by RP3 trials 🔸choose less toxic agent first 🔸 tx duration still a matter of debate; 6-months reasonable window to assess efficacy #ESMOSarcomaAndRareCancers24
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📊 more on MDM2 inh #brigimadlin in #liposarcoma at #ESMOSarcomaAndRareCancers24 🔗 similar ORRs in DD and (exceptional!) WD-LPS (18.6/15%) 🔗 systemic tx in WDLPS has to be balanced with symptoms & QoL 🔍 how to decide? A role for MDM2 no. of copies? (➡️Bevill, Cell Genom 2023)
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“Difficoltà operative di gestione” -> Manganello indiscriminato. Che vergogna @poliziadistato @Piantedosim
Questo è il comunicato stampa della Polizia di Stato riguardo alle cariche agli studenti di Pisa e Firenze. Si motivano le manganellate con una presunta "tensione" causata dal fatto che a un certo punto il corteo avesse deviato rispetto al percorso concordato. Il comunicato è
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I just would like to share how my country deals with unarmed teenagers manifesting for calling a ceasefire in Gaza. Of course, no policeman can be identified as no ID code is worn. I am truly horrified.
Ancora una volta manganellate contro chi protesta per il massacro in corso a Gaza. Questa volta a Pisa, ai danni di studenti, giovanissimi. Altri episodi ci sono stati a Firenze. Sono immagini preoccupanti, non degne del nostro Paese. Non può essere questa la risposta dello Stato
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glad to share our recently published comprehensive #review of #KIT inhibitors in #GIST 📚💊 @DrCeSarcoma @VHIO
https://t.co/HehsjduPWc
tandfonline.com
Approximately 90% of gastrointestinal stromal tumors (GISTs) are driven by activating mutations in receptor tyrosine-kinases KIT or PDGFRA. Despite the outstanding results of first-line imatinib in...
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first data on BRD9 degrader FHD-609 in #synovialsarcoma at #CTOS2023 by @jalivingston_md. Effective degradation of target did not translate in meaningful activity. Chromatin remodeling complex remains an elusive and intricate drug target.
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Europe’s power outage: How Israel-Hamas war exposed EU’s irrelevance – POLITICO
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A #sarcoma made it to @NEJM! 📌 Nearly 40% ORR and long mDOR achieved by atezolizumab in #ASPS 📌 1st IO indication in sarcomas 📌 no ORR difference by previous TKI more research is needed to understand mechanism of response..and unresponsiveness! https://t.co/u3XLXd8Aqr
nejm.org
Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a poor prognosis and no established therapy. Recently, encouraging responses to immune checkpoint inhibitors have been reported....
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Massive work on #proteomics in #sarcoma with a whole bunch of interesting findings: - #complement inhibition as a possible key for immune-cold STS - #DDR protein enrichment in SS and much more Kudos to @HuangLabICR for this effort @NatureComms
https://t.co/g4AyUWau7Y
nature.com
Nature Communications - Characterising the molecular profile of soft tissue sarcomas (STS) remains critical. Here, the authors analyse samples from 321 STS patients across 11 histological subtypes...
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🩸Hoy aquí, con mi medallita del #reptedor, participando en el Maratón de donación de plasma de @VHIO ! 🏅 Una horita de nuestro tiempo puede contribuir a salvar muchas vidas. ¡Animaos a donar! @donarsang
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honoured to having been a part in the birth of this international initiative for the advance on #patient reported-outcome in #sarcoma research & practice in the beautiful Amsterdam. Kudos for the great effort!
First day came to a close. Great presentations on development of #sarcoma PRO questionnaires on #TGCT @WTapMD & #desmoid by Mrinal Gounder and Anne-Rose Schut & TESS by Jay Wunder. Survivorship data by @OlgaHusson . Grateful to F. Pignatti for coming to reflect on EMA approach.
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📣Os esperamos en @vallhebron en la Jornada dedicada a la integración de la voz del #paciente en el proceso asistencial de los #sarcomas. @asargasarcoma 🗓️27 de Abril, h 15.00 📍Salón de Actos, planta 10, H.General 🖥️Inscripción aquí: https://t.co/XdxPCA39ed
vallhebron.com
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The Italian Ministry of Agriculture brings us back to the inglorious fascist era stating that "we cannot surrender" to the "#ethnic replacement" that is allegedly being pursued as a response to the drop of #natality rates. Another embarrassing image from Bel Paese. #Lollobrigida
Cos’è la “sostituzione etnica” https://t.co/yi0zGZSFcS
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Kudos to @cctdilab for this deep insight into the biology of clear cell #sarcoma, a hard-to-treat ultrarare histotype. Attractive hypothesis on #HER3 as a gateway to treat #CCS needs further investigation. @BrJCancer
nature.com
British Journal of Cancer - Functional genomics of human clear cell sarcoma: genomic, transcriptomic and chemical biology landscape for clear cell sarcoma
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