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jay brophy Profile
jay brophy

@brophyj

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Slightly contrarian cardiologist & epidemiologist living and working in Montreal Canada

Joined January 2009
Don't wanna be here? Send us removal request.
@brophyj
jay brophy
4 years
A slightly longer version (4 min read) of my take on the new revascularization guidelines as they pertain to LM disease can be found here @VictorDayan1 @kaulcsmc @drjohnm @DavidLBrownMD.
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@brophyj
jay brophy
9 months
Good bye X, hello BlueSky!.
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@brophyj
jay brophy
1 year
@AirCanada Perhaps AC would like to me to try later AFTER my flight has departed!
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@brophyj
jay brophy
1 year
So AC e boarding downloads still not working. They don't seem to really care. Looks like I'll need a printer to board later today. Thanks for the lack of help. @AirCanada.
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@brophyj
jay brophy
1 year
First time publishing on Medium
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medium.com
Something old and older
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@brophyj
jay brophy
2 years
Just my 2 cents, but 👎👎👎to the new @Twitter name and logo.
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@brophyj
jay brophy
2 years
New @nejm study median 5.1 years MACE = 4.81/1000PY in #pitavastatin and 7.32/1000PY in placebo. Text claims 5 year NNT = 106. What am I missing? Looks like 5 year NNT = 1/(7.32/1000-4.81/1000) = 398 to me. Statistically significant but clinically?.
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nejm.org
The risk of cardiovascular disease is increased among persons with human immunodeficiency virus (HIV) infection, so data regarding primary prevention strategies in this population are needed. In th...
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@brophyj
jay brophy
2 years
Sad day - my old friend towed way to its demise. But broken power steering, gas leak requiring open windows, battery needing constant jumping, slow tire leak, and the family of mice living in the trunk, just added up to too much. Last drive yesterday, 20 years was a good run!
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@brophyj
jay brophy
2 years
Another image from early am run
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@brophyj
jay brophy
2 years
No phone with me, so this is the best I can do to show the beauty of an early morning country run.
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@brophyj
jay brophy
2 years
Have a short article deals with teaching, research, biases, critical reading, and foundational past research. No natural home and no interested publisher. So 1st use of Also available on my webpage
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medium.com
In the winter semester we teach a small group learning course on critical appraisal for MPH students. The goal is not simply to “trash”…
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@brophyj
jay brophy
2 years
Building consensus - much published literature of questionable veracity. Read 3 articles this week where conclusions are IMHO, at least marginally, misinformed, or maybe being too “picky”? Discomfort due to (mis) interpretations of p values. Details here
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@brophyj
jay brophy
2 years
Kudos for #nejm article tackling challenging Q of extracorporeal CPR vs conventional CPR. Can Bayesian analysis provide additional insights into the published conclusion of “similar effects on survival”? One answer here @f2harrell @kaulcsmc @drjohnm
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@brophyj
jay brophy
2 years
About 4 years ago, my son and his wife adopted 2 feral kittens. Guesses as to how many future feral kittens this act may have reduced? .Nice bit of #rstats coding here suggests somewhere around 75!
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@brophyj
jay brophy
3 years
Without the dog walks, not sure I would get out to enjoy these rather brisk temps, somewhere around -40 to -45C with the wind chill. Not sure how much more of this weather is on the horizon as our local groundhog has died (& made international news)
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@brophyj
jay brophy
3 years
Ok can’t get rid of NHST, how about some common sense in interpretation. Recent paper “hs-cTn was associated with a shorter length of stay (median 47.6 hours vs 48.0 hours; ratio: 0.94; 95% CI: 0.90-0.98).” Δ 24 min! Clinically meaningful? Measurement error? Confounding?.
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@brophyj
jay brophy
3 years
Getting ready for Christmas dinner, along with the youngest family member. Also appreciating how lucky we are to have health, food, shelter, and security.
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@brophyj
jay brophy
3 years
Once again the BMJ is ahead of the curve @KamranAbbasi @fgodlee.
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bmj.com
Regulatory decisions fall short of the wise stewardship required during a pandemic On 1 October 2021 Merck issued a press release1 reporting an interim analysis of Move-Out, a phase 3 randomised...
@EricTopol
Eric Topol
3 years
Just out @TheLancet .Failure of Molnupiravir to reduce Covid hospitalizations or deaths in a very large randomized trial (N>25,000 participants, mean age 57, 99% vaccinated)
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@brophyj
jay brophy
3 years
Are 1) all 18 authors statistically incompetent? Or 2) Only the 1 or 2 authors who probably did the work are incompetent and the other 16-17 just couldn’t be bothered to critically read something they signed their names to? . 2/2.
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@brophyj
jay brophy
3 years
Just reviewed paper with 18 authors - conclusion no morality difference btw 2 contrasts (RR 1.0, 95% CI 0.5-2.0). Obvious faulty conclusion that mixes "absence of evidence with evidence of absence". My existential question is . 1/2.
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@brophyj
jay brophy
3 years
My university sends weekly teaching tips with a photo header. Today’s doesn’t represent anything I see in class.Is this because.1. My questions are too hard or uninteresting.2. Instructor in photo has just said “Screw it, who agrees, no final, everyone just gets an A”.3. Other
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