@brendonneuen @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Do you think the DKA and mycotic genital infections are enough to warrant NOT using SGLT2i Or, in other words, how much data do we need before it's medically indefensible to refuse to use SGLT2i? I struggle with some colleagues being too scared of these side effects #isnwcn

@DrRhianna @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai I think there is very clear evidence now that combined RAS blockade + SGLT2 inhibition should be offered routinely to people with DKD - especially those with macroalbuminuria

@brendonneuen @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon In case👆 @Hragy @AliElzieny @MihaiTrofenciuc @CNCFCardio @AtulPathak31 @Drpatilmansi @DrPascalMeier @GiuseppeGalati_ @SilCastelletti @JGrapsa @garand_f @DrToniyaSingh @IAmDrIbrahim @atunuguntla1 @Uqayyum123 @SVRaoMD @DrWillWatson @krychtiukmd @pabeda1 @VietHeartPA @DavidWienerMD

@brendonneuen @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Promising to see; especially given litany of negative news articles on SGLT-2 inhibitors in recent times!

@brendonneuen @gcfmd @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Do you recommend it as the next added DM2 agent over Sulfonylureas, GLP-1 agonists and DPP-4 inhibitors if 1st-line Metformin (assuming Cr < 1.5 M, Cr < 1.4 F) is insufficient? What are the incidences of UTIs (Cystitis, Pyelonephritis), Bone Fractures, Diabetic Ketoacidosis? 1/

@brendonneuen @Thomas_Hiemstra @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Fantastic outcome some hope for our patients

@brendonneuen @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Hoping this landmark trial will spur on @Drug_Evidence + @adriandix to reassess BC #Pharmacare coverage #CKD #DM #Diabetes #IHD @BCPharmacists @DoctorsOfBC @joyofmed

@brendonneuen @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Thanks to #ISNWCN for allowing me to meet new innovators! Hope to connect again. @brendonneuen

@brendonneuen @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai Did anyone happen to see what the difference in glycemic control was for the placebo vs canagliflozin group?

@brendonneuen @kdjhaveri @NEJM @ISNWCN @VladoPerkovic @hswapnil @kidney_boy @georgeinstitute @DanielJDrucker @edgarvlermamd @scoca1 @cpcannon @AnastasiaSMihai We'll see, "said the Zen Master"!!