🌍💪 Amidst turbulence, it is important not to forget our progress as a species! 🚀 During the last century, basic sanitation improved, child mortality reduced, and GDP soared worldwide! 📈 Science's role is paramount in our advancements, and safeguarding its freedom is crucial.

Our new paper in Nature Mental Health - why everyone treated with clozapine should be offered ACKR1 testing to identify individuals with benign neutropenia who can safely continue clozapine therapy. https://t.co/u9mc24DIqz

ECT is by far most effective/safest/fastest treatment for depressions that are: 1)very severe; 2)psychotic; or 3)unresponsive to meds. Underused because of: 1)stigma; 2)misinformation campaigns; 3)poor access; 4)inconvenience; 5)neglect in training See why my 1st choice for me:

Swedish authorities are considering requests for “de-diagnosis services” for autism and ADHD from a new patient group: adults who no longer want their diagnosis https://t.co/31BOnTb3nl

Viewpoint: Patients with psychotic conditions often wish to stop antipsychotics, suggesting a shift to shared deliberation for collaborative management of associated risks. https://t.co/adUvZDfVUV

"While several medications [for child obesity] demonstrated greater weight loss than placebo, the totality of the evidence was found to be inadequate. An important limitation of the pharmacotherapy studies was that there was only a single trial for each effective medication (ie,

NCI: Large analysis finds that for healthy adults, taking multivitamins daily is not associated with a lower risk of death.

Don't know if others were aware of the passing of @CoyneoftheRealm a frequent poster here and elsewhere. Here is his obit

Esketamine nasal spray as a monotherapy improved depressive symptoms in treatment-resistant depression (TRD) compared to placebo. https://t.co/qTTQmTerKA

Only 10-30% with bipolar take lithium, but 90% of experts in new survey rank it their top choice: https://t.co/CQq2VAzOJW Why? Better long-term outcomes, and addresses underlying causes of the disorder in new review by R Post et al: https://t.co/CQq2VAzOJW

Viewpoint: Target trial emulation can improve observational study validity by applying randomized trial design principles, but it is not a substitute for randomization. https://t.co/nMtfMxA7tG

@DrLKVaughan @pash22 @YugShankar @UMAPsUK @NHSEngland @pa_StephenNash @lengreview @gmcuk @Adam_Skeen @AHill_PlymUni @bmj_latest There’s a real loss, I feel, in teaching medical reasoning at an early stage when you substitute with non-doctors, who do not possess medical reasoning. You need that training to be able to link science back to the patient to start at the foundations of the degree.

Misdiagnosed as having depression? You’re not alone. Many with bipolar are first told it’s depression and spend years on the wrong treatment​. It’s frustrating, but you're not alone. Keep pushing for a proper psychiatric assessment – the right diagnosis is the first step toward

"A GO term analysis? how is this helpful?"

Anti-psychiatry has plenty of brilliant minds who can tear the field apart with philosophy, rhetoric, and clever arguments. But none of that survives a single shift in a psych ER.

https://t.co/lW6Sh6yYp4

Relapse prevention isn’t just humane; it’s economical. Let’s shift focus to long-term mental health care.

Bipolar disorder and artistic temperament: Mechanisms Linking Creativity and bipolar disorder.

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (@altos_labs 🤑), why the epigenome changes with age at all is unclear. In @NatureAging today, we suggest a potential driver: somatic mutations.

https://t.co/bCELwfIst0

My polemic in Nature on probability has attracted some attention https://t.co/rSzPgE8tg4 - you should be able to download from here https://t.co/vGD4afkNWw