Ben Lehner
@BenLehner
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Head of Generative and Synthetic Genomics @sangerinstitute; Systems + Synthetic Biology @CRGenomica; Co-founder https://t.co/5N3PvqNXec https://t.co/l6NKYFgZBP
Barcelona | Cambridge
Joined April 2009
Only a few days left to apply to become a group leader in our Generative Biology programme at.@sangerinstitute .
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New preprint: Allostery is a widespread cause of loss-of-function variant pathogenicity by the great @liao_xiaotian .
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The evolution of allostery in a protein family. New preprint from the brilliant @ainamartiaranda. Seven complete allosteric maps.
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RT @immunobananna: Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall?.In our new study….
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Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute . Building AI models or the data to train them? . Core funding of >$130M a year for a faculty of ~30. pls RT!..
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New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @Bennibolo @CRGenomica @sangerinstitute @IBECBarcelona
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RT @mo_lotfollahi: I’m excited to co-host the new #AIxBio conference alongside @Avsecz, @ferruz_noelia, @pdhsu, @BenLehner, @ml19, @deboram….
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RT @eventsWCS: Could #AI be a game-changer for #BiologicalResearch?. Join us for #AIxBio25, our new conference on the transformative potent….
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3 great computational positions open at @ALLOXbio to work with the great @aj4re @JuliaDiumenge @pbcenturion @mseumaar.
At @ALLOXbio we now have 3 computational positions available!. 📌Structural Bioinformatics Scientist 👉 📌Platform Bioinformatician 👉 📌Computational Chemist 👉 Apply or repost to help us spread the word 🙏
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RT @JonasKoeppel: I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases….
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RT @JonasKoeppel: If you’d like to work in this exciting science area, @LeopoldParts lab at the @sangerinstitute is hiring postdocs! This i….
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RT @JonasKoeppel: We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and….
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RT @CRGenomica: Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps th….
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RT @sangerinstitute: Protein instability is the main driver of inherited genetic conditions, according to the largest map of protein varian….
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RT @manuelansede: The first ‘human domainome’ reveals the cause of a multitude of diseases. An ingenious large-scale experiment in Barcelon….
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RT @taylor_mighell: We think this demonstrates massive potential for pharmacological chaperones for treating a large number of individuals….
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RT @BiologyAIDaily: MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis, and allostery….
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Can a single small molecule rescue the stability of nearly all mutations in a protein?.Our new preprint by @taylor_mighell + thread.
A major challenge in treating rare genetic diseases is the huge number of causal variants in different individuals. This led to assumptions that any given treatment would be suitable only for a small fraction of patients.
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