Ling Ding
@bcdingling
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Natural product chemist, associate professor at Technical University of Denmark
Denmark
Joined December 2017
Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus
biorxiv.org
Nyuzenamides belong to the class of bioactive cinnamoyl moiety containing non-ribosomal peptides (NRPs). However, their biosynthetic gene cluster (BGC) remains unconfirmed. Genome-mining revealed a...
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Winter is approaching and it is time to get busier to store enough food.
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Our work in using bacterial metabolites help crops grow better under abiotic stresses.
dtu.dk
Worldwide farmers are experiencing reduced yields due to conditions such as drought and increased salinity, that are only intensified by more frequent and extreme climate events. DTU start-up,...
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Fighting AMR by the antifungal drug candidate alligamycin https://t.co/UlxWfPYpmj
@tilmweber @zhijie_zj #antibiotics#AMR#Aspergillus#antimicrobial#
communities.springernature.com
Invasive fungal pathogens cause 3.8 millions of death worldwide. There are only four main classes of antifungal drugs and they are limited by toxicity, drug-drug interactions and antibiotic resista...
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Invasive fungal infections kill 3.8 millions of deaths annually. Current antifungal medicines are limited by toxicity, drug-drug interactions and resistance. We report alligamycin as a novel antifungal lead against resistant Aspergillus and Talaromyces.
nature.com
Nature Communications - From the rapamycin-producer Streptomyces iranensis, authors report on the discovery of the antifungal candidate alligamycin A, which exhibited strong activities against...
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Systematic discovery of antibacterial and antifungal bacterial toxins | Nature Microbiology
nature.com
Nature Microbiology - Genome sequence mining and computational analyses lead to the discovery and functional characterization of conserved bacterial toxins with activity against bacteria and fungi.
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Antimicrobial resistance: a concise update - The Lancet Microbe
thelancet.com
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5��million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and...
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We are looking for a passionate natural product chemist. Please check out the position here.
efzu.fa.em2.oraclecloud.com
We are looking for a highly motivated microbial natural product chemist to characterize the complex chemical structure and understand the roles of secondary metabolites in marine and soil microbiomes.
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We have an open position for a PhD in natural product chemistry.
efzu.fa.em2.oraclecloud.com
We are looking for a highly motivated microbial natural product chemist to characterize bioactive molecules and their biosynthetic pathways.
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Bacteriocin diversity, function, discovery and application as antimicrobials | Nature Reviews Microbiology
nature.com
Nature Reviews Microbiology - In this Review, Sugrue, Ross and Hill explore recent developments in bacteriocin research, including new discoveries and bioengineering approaches for improved...
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Check our recent publication on heterologous expression of a bifunctional enzyme
pubs.acs.org
Isoquinolinequinones represent an important family of natural alkaloids with profound biological activities. Heterologous expression of a rare bifunctional indole prenyltransferase/tryptophan...
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Compounds belonging to ansamycins, e.g., rifamycins are an important class of natural products. Here we report new hygrocins from the rapamycin-producer S. hygroscopicus.
pubs.acs.org
Ansamycins, represented by the antituberculosis drug rifamycin, are an important family of natural products. To obtain new ansamycins, Streptomyces rapamycinicus IMET 43975 harboring an ansamycin...
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Spirolactone, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis
biorxiv.org
Fungal infections pose a great threat to public health. There are only four classes of antifungals that have limitations due to high toxicity, drug-drug interactions, and emerging drug-resistance....
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Azoxyl compounds are a group of natural toxins. Interested in their biosynthesis? Here comes our recent work.
pubs.acs.org
Azoxy compounds are a distinctive group of bioactive secondary metabolites characterized by a unique RN═N+(O–)R moiety. The azoxy moiety is present in various classes of metabolites that exhibit...
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Our paper on access to pepticinnamins by inactivation of the azodyrecin BGC.
pubs.acs.org
Cinnamoyl moiety containing nonribosomal peptides represented by pepticinnamin E are a growing family of natural products isolated from different Streptomyces species and possess diverse bioactivit...
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In honor of #WorldAnthropologyDay, learn more about how the spread of agriculture didn’t just change our diets—it altered our jaws as well, making it easy to pronounce "f"s and "v"s and opening a whole new world of words. https://t.co/AM1BoB2onQ
@NewsfromScience
science.org
How farming reshaped our smiles and our speech
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Outdoor Jogging:) Dragon means power, strength, vigour, and charm. I wish a peaceful world and healthy planet.
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