I had a lot of fun modeling cytokinetic ring assembly for this project out now in @BiophysJ! https://t.co/XpNY9KTyLy

I've put together a few of my favorite discussions on the details of doing molecular dynamics. I'll add more as they come. Hopefully they're useful to you! 🧵1/n

I am excited to share a new study led by Shachar Givon & @MatanSamina w/ Ohad Ben Shahar: Goldfish can learn to navigate a small robotic vehicle on land. We trained goldfish to drive a wheeled platform that reacts to the fish’s movement ( https://t.co/ZR59Hu9sib).

A factbook that’s organized by how expensive it is to verify each fact. The spectrum is like “you can observe this with your naked eye” → “you need a billion dollar Hadron Collider to know this”

Many single protein chains can be accurately predicted using AlphaFold, but multi-chain protein complexes remain challenging. Introducing AlphaFold-Multimer, a model that can predict the structure of multi-chain protein complexes with increased accuracy https://t.co/KMyN87wgDE 1/

β- and γ-cytoplasmic actins have different translation rates in cells and exert different nucleotide coding sequence-dependent effects on cell migration https://t.co/CnSNefNkOC

We are looking for interns! Apply before October 4th.

nice combination of biochemistry and fly genetics shows profilin can both promote actin polymerization and disassembly. binding to Mical-oxidized G-actin inhibits profilin's polyz'n activity https://t.co/b6VpNNt6nn

Our latest paper about #microrobotic #crowdsurfing!! These #activecarpets can transport heavy objects and liquids amphibiously, like #cilia, and sort this cargo by size and shape. Congrats @DemirorsAhmet et al! https://t.co/bxwFa5fKbx

Have you seen a colloidal particle eating up bacteria?

(1/3) BMB is looking for our next best junior faculty recruit! If you are a biochemist, structural biologist or in related disciplines, and are on the market, take a look at our ad https://t.co/YuiUpyei3y and consider applying. @ASBMB @ProteinSociety @BiophysicalSoc @ccp4_mx

Assistant Professor - Interface of Immunology and Chemistry - Molecular and Cell Biology and Chemistry - ⁦@berkeleyMCB⁩ ⁦@UCB_Chemistry⁩

In contrast, the elongation rates of the various formins were much less impactful on ring assembly, in agreement with the computational model. We also looked at the effect of formin mechanoinhibition on ring assembly– Check it out!

By engineering yeast strains that target different formins to the cytokinesis nodes in place of WT formin Cdc12, we observed robust ring assembly for formins having similar nucleation properties to Cdc12 and defects for formins with dissimilar nucleation.

We explored how changes to these properties impact cytokinetic ring formation in fission yeast. Our simulations indicated that formin's ability to nucleate filaments was significantly more impactful than the rate at which it elongates them.

Formins shape the cytoskeleton by nucleating and elongating actin filaments. Within a single cell, multiple formin isoforms are targeted to specific actin networks, and each of them have distinct nucleation and elongation properties.

Join us at Uchicago ! Please reach out if you have any questions ! https://t.co/aGWycxF4pr @UChiChemistry

We present ~2.8 A cryo-EM structures of actin alone and nucleotide-free (rigor) wild-type myosin-15 bound to F-actin, as well as wild-type myosin-15 in the ADP state (3.6 A) and the jordan mutant the rigor state (3.8 A) to investigate how myosin-15 regulates actin assembly.

"Congratulations to MB&B department chair, Dr. Enrique De La Cruz, for being inducted into the inaugural class of American Society for Biochemistry and Molecular Biology (ASBMB) Fellows. " Full story here: https://t.co/8H3FUmtcfk