Barbara Hollunder
@b_hollunder
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PhDing @ChariteBerlin @ECN_Berlin @MindaBrain I Fascinated by connectomic neuromodulation, science illustration & dad jokes I Happiest on a bike.
Berlin
Joined July 2020
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Intrigued to discover more about how DBS reveals & therapeutically impacts on the dysfunctional circuits behind different brain disorders, from OCD to dystonia? 🪄🧠
So were we! Join us on this deep dive from core to cortex – now out
@NatureNeuro
:
A 🧵
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🥁Thrilled to share our newest preprint on a concept near & dear to me:
🧠⚡️To leverage the potentials of invasive brain stimulation combined with connectomics as a tool to derive at causal neuroanatomy-function mappings within the human brain.
A 🧵
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Who would've thought our study would make it to the big screen? 🤯Thanks for the spotlight,
@CNN
! 🎬
🎩 off to the patient for sharing her experience & to the incredible clinical team around
@DarinDougherty
!
Read the full story here:
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If bringing this study to life was the icing on the 🍰, then this fun 🎄-project-unexpectedly–turned–cover art is undeniably the 🍒 on top!
🙏🙏 to the muses
@andreashorn_
@TriciZvar
&
@P__Reinhardt
for plotting this together & infusing science with fun–team effort all the way!
Excited that our article 👇👇 has been featured on the cover of the march issue of
@NatureNeuro
– even more excited that
@b_hollunder
, the first-author of the study, hand-drew the cover herself. [🤫 I think she’s an artist]
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Might need to pass this through
@leaddbs
for a quick electrode placement check! 🪄 Looks like we've still managed to hit a 'sweet spot' though 🤷♀️
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Come meet
@NingfeiL
and me at our poster (P 17) at the DBS Expert Summit to discuss how connectomic DBS may serve as a flashlight into the functional organization of the prefrontal cortex. We will also pitch our project at the DGKN & would be happy to see many of you there!
We’re very much looking forward to the
@Retune_CRC
next week in Würzburg!
Our lab will present 5 posters – if you want to get a headstart and/or can’t attend, check them out here:
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Mind-boggling to see my first PhD paper out in
@BiologicalPsyc1
, largely fueled by fantastic teamwork with shared first & friend
@NingfeiL
, supportive mentorship & guidance by
@andreashorn_
and the many inspiring co-authors! 🤯🥳🧠 1/n
Have a look here:
Excited to complement
@NingfeiL
's
@NatureComms
paper on a structural connectivity target for OCD-DBS now by functional connectivity analyis out in
@BiologicalPsyc1
@SOBP
.
Amazing work spearheaded by
@NingfeiL
and
@b_hollunder
– a 🧵 summary 1/n
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7/n: Urgently needed for precision treatment: a roadmap that unequivocally establishes a relationship between circuitry & symptom. Conventional functional neuroimaging has not always been conclusive. Highly recommended reading
@shansiddiqi
@foxmdphd
et al:
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Happy to break the news: this October, we're starting a new network neuromodulation-themed
@stimbrains
talk series where you can also get a glimpse of the people behind the science! Learn all about the idea behind it 👇 and sign up for the initial round:
✨Exciting times: The podcast is getting a little sister – a talk series on connectomic neuromodulation & the inspirational thinkers behind it! Curious?
💡Inaugural talks:
@karaannjohnson
& Ludvic Zrinzo
⏰ Oct. 26, noon ET/6 PM CET
📍Zoom (registration: )
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14/n: Subthalamic sweet spots followed a caudo-rostral lateral-medial organization from DYT to TS, PD, & OCD. This pattern converged with functional territories: DYT in the sensorimotor, TS in the motor, PD in the motor-premotor, & OCD in the associative-limbic STN.
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The
@stimbrains
talk series is back from hibernation! On Jan 25, noon ET / 6 PM CET, the fabulous
@rlofredi
&
@BergmanHagai
will take us onto a tour of the whatabouts of the hidden structures deep inside the brain! To join us on Zoom, simply register here:
Very much looking forward to the next issue of
@Brain_Circuits
@stimbrains
next Wednesday - with none less than
@BergmanHagai
and
@rlofredi
! Free for all - join us online!
@b_hollunder
@TriciZvar
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The next session of our
@stimbrains
talk series will feature an absolute
@Brain_Circuits
dream team with
@shansiddiqi
&
@foxmdphd
! 🥇
💡Join us for an inspiring & insightful session (03/30, noon ET/6PM CET)!
Registration to receive the (free) Zoom link:
🥁, please: Our talk series is back with a 💥with none less than
@shansiddiqi
&
@foxmdphd
!
Tune in to hear about causal mapping of human 🧠 function & get a glimpse of the legends behind the science!
📆 03/30 (noon ET/6PM CET)
💻 Registration:
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Wonderful to see this important contribution on the connectomic bases of therapeutic DBS for AD by
@sofiari91
,
@andreashorn_
and colleagues out
@NatureComms
! 👏 🍾 Congrats to the team for pulling this major effort off!
Excited that our Connectomic DBS for Alzheimer's Disease is online at
@NatureComms
since today!
Paper here:
Tweet summary (based on the preprint) here:
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5/n: With 39 researchers from 16 institutions involved, the importance of collective effort in this project cannot be overstated. We are deeply indebted to the invaluable data & profound expertise contributed by each & every single collaborator – but no less to the patients!
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✨Happy news on a Monday! Our recent publication on connectomic DBS in OCD, published at
@BiologicalPsyc1
, just got a shiny new layout ✨- follow this link for free open access and have a look at the final version:
Final version of
@NingfeiL
&
@b_hollunder
's connectomic DBS paper about OCD networks investigated with rs-fMRI with
@BiologicalPsyc1
@SOBP
now online, sharable link w/ free access here:
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What a beautiful result of a massive collaborative effort, masterfully orchestrated by
@andreashorn_
! Still can't quite believe being a small part of it together with
@NaN_Value
, among all these DBS giants across the globe!
Very excited to announce our book on Connectomic Deep Brain Stimulation is out for preorder here:
w/
@foxmdphd
@AndreaKhn1
@HarithAkram
@richardfbetzel
@jmacshine
@ThijsDhollander
@neumann_wj
@jclauneuro
@shansiddiqi
@DembekTill
@eduardo_alho
@BaldermannJC
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Today, academia meets industry as we uncover cutting-edge insights on TMS for "loss of control" disorders & beyond in our virtual
@stimbrains
talk series, March edition feat.
@SoleimaniGhazal
&
@brainstimgrl
!
Join us at noon ET / 5PM CET – Zoom link via !
🚀Happening today!! ✨
Don't miss out on this exciting session of our talk series feat. the brilliant
@SoleimaniGhazal
&
@brainstimgrl
discussing their thoughts on non-invasive neuromodulation in psychiatry!
📅 noon ET / 5PM CET
📍 Zoom
💻 Register @
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Two truly outstanding female neurosurgeons,
@VVV_Cologne
& Marie Krüger, coming together to share their wisdom on DBS for pain, Tourette's, OCD & Alzheimer's – along with their sources of inspiration! 🦸♀️⚡️🦸♀️What more could we hope for? (Free) registration:
Excited about the February edition of stimulating brains – with
@VVV_Cologne
and Marie Krüger, two excellent functional neurosurgeons from Cologne & London both working on very innovative DBS targets & strategies!
Register here (free of charge):
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10/n: DBS Fiber Filtering () is a powerful method for identifying dysfunctional circuits. Applied repeatedly across different brain disorders, it may help build a circuit library within the connectome, essentially creating a map of the human 'dysfunctome'.
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Fantastic opportunity for an MD to work with the one and only
@neumann_wj
in Berlin! Extremely supportive mentor & team plus super cool research & top-notch (international) collabs – highly recommended! 💥👇
The
@ICNeuromodulate
lab is hiring a medical doctor for
@ERC_Research
#StG
on
#reinforcement
effects of
#deepbrainstimulation
in
#Parkinson
disease at
@ChariteBerlin
. Come discover how we support instead of disrupt brain circuit activity with
#DBS
,
#ECoG
&
#MachineLearning
.
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17/n: Cortical sites of interconnection of these tracts mirrored the gradient of that present within the STN. Modulating connections from sensorimotor cortices in DYT, from M1 in TS, from SMA in PD, and from vmPFC, ACC, dlPFC & OFC in OCD linked to respective improvements.
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3/n: This massive project is condensing 4+ years of intense collaborative work & a large chunk of my PhD – needless to say we’re over the🌙 that we are finally being able to share this with you!
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8/n: Here, we took a different route, combining invasive brain stimulation with high-resolution connectomics to derive at dysfunction mappings within the brain.
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9/n: DBS may be ideally suited: 1) It precisely targets focal neuroanatomy; 2) it frequently results in significant symptom change; 3) it creates an ‘informational’ lesion that can downregulate aberrant information processing in dysfunctional circuits ()
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12/n: These 4 disorders all present quite differently from each other – so DBS treatment targeted to the same small nucleus providing symptom relief across all of them is rather curious. This paradox, however, came handy as it allowed mapping dysfunctional circuits comparatively.
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2/n: TL;DR – find digestible summaries of this work here:
@NatureNeuro
Research Briefing –
Press releases by
@ChariteBerlin
–
Press release by
@BrighamWomens
–
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27/n: Taken together, our findings illustrate that the STN appears to contain a miniaturized representation of fronto-cortical dysfunctional topography.
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Hold onto your 🎩! We've got a mind-bending session lined up w/
@NolanRyWilliams
& Mustafa Husain this April! From ECT to TMS & magnetic seizure therapy, we're diving into the electrifying zaps & zings of 🧠⚡️
📅 April 25 (noon ET/6PM CET)
📍Zoom 🔗 via
We’re thrilled to announce the April edit of our talk series feat. the legends
@NolanRyWilliams
& Mustafa Husain 🪩 Join us for a journey from ECT to cutting-edge TMS protocols & magnetic seizure therapy!⚡️
⏰04/25 (noon ET/6PM CET)
🚩Zoom
💻Registration:
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Mind-boggling insights on the connectomic substrate of successful forniceal DBS for treatment of AD! Super impressed by the unparalleled persistence and enormous efforts of
@sofiari91
,
@andreashorn_
& colleagues! 🤯 This gets me really excited about the future of this field! 🚀
So happy to share this 🙌 lots of fun and learning with an amazing team of scientists
@simonoxen
@c_neudorfer
@NingfeiL
@NaN_Value
Konstantin. Guided by the fantastic mentorship of
@andreashorn_
🤓 very grateful for the opportunity to work on this data with such wonderful people!
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What a dream come true to see
@LennartVerhagen
& dear friend
@NaN_Value
share insights on precision neuromodulation from different angles this Friday in a hybrid (Berlin-based & Zoom) edition of our
@stimbrains
talk series! 😍
💡Registration & info here:
💥Only 3 MORE DAYS till we get to hear about (non)invasive precision neuromodulation from the one of a kind duo of
@LennartVerhagen
&
@NaN_Value
! 🤯
Reserve your (virtual/in-person) spot via !
🍻🍕Apéro from 5:15 PM CET
🗣️Talks from 6 PM CET/noon ET
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Hooray, many congrats to
@NingfeiL
&
@andreashorn_
! Can’t wait to see more fantastic research by you two in the near future! 🥳
Congrats to
@ningfeil
,
@andreashorn
and colleagues “A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder”
@NatureComms
was elected by the CSB directors as
#paperofthemonth
August 2020
#CSBPOM
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30/n: The intricacies of the ‘dysfunctome’ are vast & the disorders it encompasses are diverse. With continual data influx & enhancing spatial imaging precision, we at the
@netstim_org
are hoping for many others to join us in our quest to characterize it in ever more detail!
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What an inspiring keynote
@OHBM
tonight! Thank you
@nastasiayendiki
for taking us on this exciting adventure into the more secluded parts of the brain!
#OHBM2022
Beyond the highways and into the dark alleys of the brain...
@chiaramff
@FuyixueWang
@Haber_Lab
@OHBM
#keynote
#OHBM2022
Very grateful for awesome coworkers.
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6/n: But now let’s dive right into the core of the problem: Brain disorders manifest in a multitude of forms, from intrusive thought to involuntary movements. Pinpointing where exactly things go awry in the connectome is key for their targeted treatment. Not an easy challenge!
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4/n: Immense gratitude to
@NingfeiL
for being the yin to my ☯️ during this 🎢 & to
@andreashorn_
for being the lighthouse that guided us while turning our vision into reality. Their unwavering support was the cornerstone of this project's success!
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A lot of great discussion with brilliant scientists, which considerably pushed this project forward, actually happened at the last edition of !
Highly recommended attending (June 12-14, 2024), this is where the magic happens! ✨💫
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37/n: For an in-depth exploration of our findings & their detailed interpretation, we recommend reading the complete article. Open access to the expanded PDF version at: . A research briefing has been published alongside the article:
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Such important topics! Feeling truly humbled to receive an up-to-date overview from these two legends in our upcoming
@stimbrains
September edit!
Everyone warmly welcome, bring all your interested friends & colleagues! 👋
Zoom link via
As excited as we are about our upcoming talk series event on quality of life after DBS with the legendary Günther Deuschl &
@DafsariHaidar
?
🏁Then get on your marks, get set, & go to to save yourself a front-row spot!
📍Zoom
⏰Sept 28 (noon ET/6PM CET)
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If much like me, you're really into connectomic neuromodulation, mark your 🗓️ & go to to sign yourself up for this (free) virtual event! Can't wait to soak up all the knowledge from these two superstars
@EMiddlebrooksMD
& Alexandre Boutet! 👨🎤🌟
The November edit of our talk series is around the corner! It will feature two awesome speakers who are ready to inspire you with scientific insight & beyond!
💡
@EMiddlebrooksMD
& Alexandre Boutet
⏰ Wed, Nov 30 (noon ET / 6 PM CET)
📍Zoom (registration: )
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Perfect stage worthy of the queen of research talks! 👑 Well done,
@meerachikermane
!
Returning to twitter after a long break. Honored to start by sharing my doctoral research talk connecting Dopamine and Beta oscillations in humans at
@MGHNeuroSci
@harvardmed
-
@MIT
joint symposium in Boston.
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11/n: Using DBS Fiber Filtering, we investigated dysfunctional circuits in 261 patients treated w/ 534 DBS electrodes generously shared in a large multi-center collaboration involving 10 specialized centers in 7 countries. Patients received DBS to the STN for PD, DYT, OCD, or TS.
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Before tackling the circuit level, we first took a closer look at the target level. Specifically, we applied DBS Sweet Spot Mapping () to investigate focal stimulation sites associated with clinical improvement in each of the four brain disorders.
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Wanna luck out and have
@andreashorn_
as a mentor? You like having waffles and really good coffee as much as we do? Come join our international, interdisciplinary and food-swap avid team
@ChariteBerlin
! 🙋♀️
3-year post-doc position in our lab (
@ChariteBerlin
) to work on
#connectomic
#deepbrainstimulation
research using
@leaddbs
. Please RT for reach, thank you! 🙏
See our philosophy / labmanual here:
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10/20. Via
@leaddbs
, we performed DBS Sweet Spot Mapping to investigate focal stimulation sites associated with disease-specific clinical improvement, & DBS Fiber Filtering to understand functionally selective effects at the level of beneficial tracts & cortical projection sites
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Inspiring keynote by Andres Lozano
@OHBM
yesterday showcasing fantastic work on AD-DBS, amongst others by my dear & super smart friend
@sofiari91
together with
@andreashorn_
@simonoxen
@c_neudorfer
and many amazing colleagues! Extremely proud to be part of such a stellar team! 🌟
Excited to be at
#OHBM2022
listening to the Talairach lecture by Andres Lozano on clinical success with deep brain stimulation.
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21/n: To further substantiate our findings, we validated tract models in two independent samples of n=32 PD & n=35 OCD patients. Notably, the OCD cohort had been implanted to the ALIC region. Indeed, overlap of stimulation volumes w/ the model could estimate clinical outcomes.
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13/n: Unsurprisingly, average electrode placement within each disease cohort was comparably similar (within the posterolateral STN) across three/four disorders. The only exception was formed by OCD where surgeons are known to deliberately target a more anteromedial STN portion.
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15/n: Similarly, filtering modulated neuroanatomical tracts from a high resolution group connectome by their relevance for beneficial outcome within the respective disorder revealed a certain degree of segregation in the topography of dysfunction mappings.
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Seize this rare opportunity to be involved in the pioneering endeavor of mapping the brain's wiring at unprecedented detail!🚀Working under the exceptional mentorship of Anastasia, this position promises immense growth & learning in an inspirational & revolutionary universe! 👩🚀🪐
We are hiring - bigly. Join the computational team of our multi-institutional BRAIN Initiative comprehensive center that will produce first-ever maps of the wiring of the brain.
Tech:
Coordinator:
Postdoc:
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24/n: In collaboration with the fantastic clinical teams at Würzburg & Boston centers, we were able to prospectively validate our tract models by circuit-guided reprogramming of one PD & one OCD patient. Major shout-out to
@DarinDougherty
@RMarkRichardson
@volkmann_jens
🙏🙏🙏
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16/n: You may now go - hah, but who tells me that this segregation was not merely driven by differences in electrode placement? Well, we got you covered & are reporting a set of data-driven control analyses in the manuscript. Go check them out if this sounds interesting!
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This was so much fun! Can't wait for more of this, June 30th feat. the fantastic
@LennartVerhagen
& dear friend / superstar colleague
@NaN_Value
! 😍😍😍
Belated recap of last night's in-person
@stimbrains
kickoff event as yesterday, we had our hands full of tasty pizza & refreshing beer!🍕🍺 WOW, what a fabulous night of science & fun, with a packed house of enthusiastic attendees for the SciApéro to mingle with the speakers!
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28/n: This spatial scaling effect may explain why we can treat heterogeneous disorders via single electrodes if we place these at the site of integrator hubs (such as the STN). It also underlines the importance of meticulous targeting – millimeters matter!
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So much looking forward to hearing from this dream duo today! 💫
Join us live at noon ET / 6PM CET via Zoom to be as inspired by these two speakers as we are!
Easy, quick & free registration at
🚨Happening 🔜 today (noon ET/6PM CET on Zoom)!
💡Don't miss out on lessons learned on facets of cognitive input to the basal ganglia from (non)invasive recordings feat. the fantastic duo of
@darcydiesburg
&
@RMarkRichardson
!
🔌Free registration open at
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What a splendid way to kick off our talk series after its summer break! So much looking forward to hearing from this great pair of speakers later today! 😍
Hej there, neuromodulation aficionados! 🙌
Secure your virtual front-row seat for today’s session feat. the inspirational
@scernera1
&
@DorisWangLab
:
🕒 noon ET/6PM CET
🚀
We cannot wait to explore new horizons of aDBS for PD motor symptoms together! 🌌
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26/n: Besides these hyperdirect pathways, the cortico-basal ganglia-thalamocortical system forms loops including indirect input from the external pallidum to the STN. Again, we observed segregation in dysfunction mappings at the level of these indirect subthalamic connections.
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Two inspirational speakers unifying manifold perspectives in one session:
💡Damiaan is a psychiatrist, neuroscientist, philosopher, theater author & TedX speaker
💡Andrada is a clinical psychologist, psychotherapist, educator & neuroscientist
Sounds exciting? Join us today👇
Ever wanted to see a real Ig Nobel prize winner speak ()?
🎯Then today's your shot when we hear from Damiaan Denys together w/ Andrada Neacsiu on context effects in brain stimulation!
⏰noon ET/6PM CET
💻Registration & link via
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36/n: My personal thanks also goes out to
@ECN_Berlin
for graciously funding a large portion of my PhD. This work further received generous funding & financial support by
@dfg_public
,
@NIH
,
@questbih
,
@dlr_musc
,
@NVFund
, & many others.
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18/n: Still, the choice of a particular normative tractogram comes both with benefits & limitations. In case you would like to learn more on the topic, read our thoughts on this here:
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Grateful for all the new insights gained through this spectacular defense talk! Thanks a lot & many congrats on your big moment, Dr.
@j_achtzehn
! 🎓🍾
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32/n: ...
@TriciZvar
M. Polosan
@HarithAkram
@MatteoVissani92
@Chencheng_Zhang
B. Sun P. Navratil M. Reich
@volkmann_jens
@FangChengYeh
@BaldermannJC
T. Dembek
@VVV_Cologne
@eduardo_alho
P. Franceschini ...
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22/n: We would like to highlight again that neither the additional OCD nor the PD validation cohorts had been used to inform the original tract models (which were built on the discovery cohorts), i.e. this validation step was not biased by circularity.
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@DarinDougherty
@RMarkRichardson
@volkmann_jens
25/n: Another beautiful example – an OCD patient treated in Brazil by P. Franceschini &
@eduardo_alho
. Optimal implantation site & stimulation settings were determined to ensure that stimulation volumes maximally engaged the tract model, leading to a symptom reduction of 77%.
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It doesn't get any better than that – thoughtful supervision, amazing team, inspiring science, all in a very beautiful campus! 💥 Go for it as fast as you can if in search of a PhD position!
🚨We are seeking a PhD student for an exciting project involving
#DBS
and intraop human single neuron recordings⚡️🧠. The student will be supervised by me &
@AA_Kuhn
. June 2023 start date. Check advert for details👇🏻RT appreciated!
@ChariteBerlin
@HertieNeuroSci
@Retune_CRC
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33/n: ... P. Nanda
@carstenfinke
@AA_Kuhn
@DarinDougherty
@RMarkRichardson
@BergmanHagai
M. DeLong
@alb_mazzoni
L. Romito L. Zrinzo E. Joyce S. Chabardes P. Starr
@NingfeiL
@andreashorn_
. We couldn't have done it without you! 🙏🙌
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Counting the days to hear the take of one of the founding figures of DBS in neuropsychiatry on the developments of the field over the past 25 years! Ready for a teaser? Read
@VVV
's Nat Medicine commentary on the influence of device manufacturers here:
The countdown is on 📆: Only 7 more nights to sleep till a shiny new
@stimbrains
talk series event comes your way, this time feat. the wonderful duo of
@VVV_Cologne
& Marie Krüger! 😍
💡Join us live on Feb 23, noon ET / 6 PM CET
👉(Free) registration:
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Definitely
#1
mentor!! 🥇 Would apply again within a heartbeat if I could!
Lots of people in my close scientific periphery at
@harvardmed
are currently hiring postdocs and RAs. I might be hiring soon, myself, as well. So do reach out if interested / know anybody interested in network mapping, DBS, connectomics etc!
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29/n: We hope that with these insights, we could convince you of the unique potentials of connectomic DBS, which may be leveraged as a flashlight into the topographical organization of dysfunction within the human connectome at all spatial levels, between cortex and subcortex.
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19/20. w/ co-authors
@OstremJill
@ilkemaysusahin
@NaN_Value
@simonoxen
K. Butenko M. Polosan
@HarithAkram
@MatteoVissani92
@Chencheng_Zhang
B. Sun M. Reich
@volkmann_jens
@carstenfinke
@AA_Kuhn
@BergmanHagai
M. DeLong
@alb_mazzoni
L. Romito L. Zrinzo E.Joyce S. Chabardes P. Starr
1
0
7
19/n: To scrutinize the influence of choice of a given connectomic resource on our mappings, we went on and confirmed the general pattern of this gradient in three additional connectomic resources of different characteristics.
1
0
8
Beautiful video tribute to connectomic DBS by
@andreashorn_
! Also nicely showcases some of the manifold options of visualization that come with
@leaddbs
🎨
Very cool "video tour through brain circuits" by
@andreashorn_
, incoming Director of
#DBS
research at the Center for Brain Circuit Therapeutics
@BrighamWomens
@MassGenBrigham
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35
98
0
1
8
20/n: But particularly relevant for clinical treatment is the question: Would these mappings also hold up in the face of disease-specific circuit alterations? Excitingly, we were able to show they would on the examples of an OCD and a PD matched connectome.
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0
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Loving this new flat share set-up & the fabulous roommates that come with it, actual living plants included! 🪴🌵🌱 Can't wait for all the fun, food, & science that will emerge from this extended (head)space between
@netstim_org
X
@ICNeuromodulate
!
New
#DBS
flat share. 2 rooms, 16 people, shared bathroom, shared kitchen, no Anmeldung.
@netstim_org
x
@ICNeuromodulate
cookouts and joint papers coming up!
@NaN_Value
@rm_koehler
@Hpourakbari88
@TriciZvar
@tsbinns
@JonathanVHoecke
@eh_harms
@meerachikermane
@MerkTimon
& more!
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7
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3
8
Super happy to see these two amazing science superheroines and female role models receiving the
#NobelPrize
for their considerable contributions! Way to go,
@e__charpentier
&
@doudna_lab
! 🥳
#STEMinist
#diversityinSTEM
#WomenInSTEM
#WomenInScience
#Charpentier
#Doudna
#CRISPR
Huge
#Congratulations
to Emanuelle Charpentier and Jennifer Doudna for their
#NobelPrize
#CRISPR
#Charpentier
#Doudna
#STEM
#Science
#Chemistry
#WomenInSTEM
#WomenInScience
#womeninchemistry
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20/20. And that’s a wrap – thank you so much for your interest in our project! We are very much looking forward to hearing your thoughts & feedback, & would be grateful for retweets if you liked this!
1
0
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It's beautiful! 😍
Would a 3D printed brain model be helpful for DBS surgery consultation? Now there's an interesting study on this Model created by
@NingfeiL
from
@netstim_org
using Lead-DBS.
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8
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Important, honest & uplifting event series about the windy roads hidden behind a polished academic CV! Highly recommended!
What we see: papers 🧾 grants 💸 prizes & accolades 🏆 fancy universities 🏰 smartness 🧠
What we don't see: detours 🤸sacrifices ✂️ doubts 🤔 rejections 🛑 frustrations 😒 mistakes 😬mentors 👩🏫 support networks 🫂 resilience 🦸♀️
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4
19
0
2
6
Fantastic to see your hard work pay off! Congrats on this big milestone,
@laurenhart098
! 🥳🎈🙌 Now off to new adventures with the
@netstim_org
!
Yesterday, I officially graduated from the Department of Psychological and Brain Sciences at Boston University, Class of 2022!! As a first generation college student this day meant so much to me 🧵
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Super excited that this is back on – the perfect kick-off for the holiday season! 🎄✨
Join us if you can: happening Thursday, Dec. 14th at noon ET / 6PM CET on Zoom!
Easy & quick registration to receive the (free) Zoom link still open at
A perfect brain boost for a gloomy winter day! 🌨️❄️ Our talk series event w/ Birte Forstmann &
@FranciscaFFerr
is back on:
📅Dec 14th
⏰noon ET/6PM CET
Already registered? The new link is coming straight to your 📧! Not signed up yet? There's still time:
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3
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0
1
7
This may easily become one of my personal highlight sessions!😍Don't miss out on this extra-special episode with the one-and-only
@vpeterson09
&
@neumann_wj
!
Sounds as exciting to you as it does to us? Good news, last-minute registration still open via !
We're super thrilled about today's session feat. the fantastic duo of
@vpeterson09
&
@neumann_wj
! 👨🎤👩🎤
Join us later (10AM ET/4PM CET) for a captivating exploration of signal processing in invasive neurophys & closed-loop DBS!
Don't miss out on these exciting insights! 🪄🧠
1
1
4
0
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35/n: We are very thankful for the enlightening discussions
@OHBM
@dbssocietyorg
@dgkn_news
& others which have shaped this project further: w/
@foxmdphd
,
@nastasiayendiki
B. Forstmann
@AndrewMosesLee1
@NeuroRae
@LennartVerhagen
@KarstenMueller6
S. Miletic
@jclauneuro
& many more
1
0
7
Couldn't have hoped for a better first intercontinental collaboration - here's to many more as new lab pals! 🥂
My first ever contribution to a scientific book, thankyou
@andreashorn_
for the opportunity & guidance,
@b_hollunder
for being an amazing co-first author! So excited!!!
0
2
6
0
1
7
Truly blown away by both your talks & the interactive and thought-provoking discussion between the two of you! Time really flew by – we couldn't have hoped for a better duo to kick off this series! 🙏🙏
So much fun! Thank you for the invite - great event with a fabulous talk by Dr. Zrinzo and thoughtful questions from the audience. Really looking forward to attending the next one 👏🏼
2
5
27
1
2
7
31/n: This project underlines what can be achieved by the joint forces of so many – it indeed takes an entire village! Here’s another big shoutout to the numerous outstanding co-authors:
@JillOstremUCSF
@ilkemaysusahin
@NaN_Value
@simonoxen
K. Butenko
@c_neudorfer
@P__Reinhardt
1
0
7
34/n: We would also like to extend our deep gratitude to
@lady_ginseng
for her continued support as senior editor, & to
@halpernc
,
@gordonneuro
, & Pierre-Louis Bazin for their insightful revisions that have notably enhanced the quality of this article.
1
0
7
Congrats to
@simonoxen
,
@andreashorn_
and team for introducing Lead-DBS to the OR! 🫡 Fantastic open science effort illustrated by beautiful figures! Check out the updated tweetorial to learn more about the many features of this exciting toolbox! 👇
Excited that
@simonoxen
’s Lead-OR toolbox paper has been published w/
@eLife
today. Much has happened till the preprint so here’s a renewed tweetorial about Lead-OR:
3
27
81
0
1
6
Exciting concept & stunning figures! 🪩 Watch this space for updates on this super cool project on personalization of DBS to symptom network constellations in PD, spearheaded by the amazing
@NaN_Value
!
Excited to present a poster on personalized connectomics- DBS at
@Retune_CRC
Fall school! Come take a look!
0
4
20
0
2
6
Today's the day!
@stimbrains
– the Talk Series, November edit with
@EMiddlebrooksMD
& Alexandre Boutet, is waiting just around the corner 👀
Save yourself a last-minute spot by registering for the (free) Zoom-based event via the following link:
💥Happening today!!💥
Stimulating Brains – The Talk Series
#2
, with exciting insights from the fantastic
@EMiddlebrooksMD
& Alexandre Boutet!
⏰ Join us live at 12 PM ET / 6 PM CET on Zoom!
💻 Last-minute registration to receive the (free) Zoom link:
0
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0
3
6
Counting down the days in anticipation of this! 🤩
Come join us to hear from two fabulous speakers – easy & free registration for the virtual (Zoom-based) event at !
STD for the May edition of our talk series w/
@darcydiesburg
&
@RMarkRichardson
, as we dive into captivating insights on the involvement of cortico-basal ganglia input in cognition from (sub)cortical recordings!
📅 05/25 (noon ET/6PM CET)
🆓 Zoom link via
0
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0
1
6
@foxmdphd
@andreashorn_
@Brain_Circuits
Well, sometimes you need to pull all the tricks, strap on those 🤿 & take a deep plunge with the
@netstim
expedition team to explore these intricate
@brain_circuits
! 🤷♀️
0
0
6
Thank you so much, Mike – your support means a great deal!🙏 With this project, our team is standing on the shoulders of causal brain circuit mapping giants like yourself & other visionaries from the
@Brain_Circuits
! Being part of this collaborative journey is truly inspiring! 🚀
What happens when you combine STN DBS datasets across multiple different neurological and psychiatric disorders? You get an awesome neuroscience resource for causal mapping of
@Brain_Circuits
. Great collaboration led by
@b_hollunder
@andreashorn_
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5
31
0
0
5
16/20. Relating cortical & subcortical gradients, our findings further illustrate that the STN contains a miniaturized representation of fronto-cortical functional topography. Beyond segregation, our results may thus be reconciled with the idea of spatial information compression.
1
2
6
8/20. We thus set out to leverage optimal connectivity profiles of invasive DBS electrodes to the STN in four different disorders (DYT, PD, Tourette’s syndrome/TS, & OCD) as a means of systematically mapping the functional organization of the STN & that of the frontal cortex.
1
1
6
Seems like we were not the only ones to think you two would be a great match! Really looking forward to your shared discussion in our
@stimbrains
talk series!
Fantastic talk on fMRI of DBS in PD by Alexandre Boutet!
@NIH
@ISMRM
I am excited to be presenting with him a second time with
@stimbrains
in the near future! Stay tuned!
@b_hollunder
@andreashorn_
0
1
23
0
3
6
✨Don't miss out on our next
@stimbrains
session feat. the exceptional Damiaan Denys & Andrada Neacsiu which will cover important topics around (non)invasive brain stim for neuropsychiatric disorders! ✨
📅 Feb 29th (noon ET/6PM CET)
🚩 Zoom
💻 Register @
This February is fully packed with extra inspiring science! 🚀⚡️
Join us for thought-provoking talks by Damiaan Denys & Andrada Neacsiu to hear their take on (non)invasive neuromodulation in psychiatry!
⏰Feb 29th (noon ET/6PM CET)
🚩Zoom
💻Register @
0
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0
1
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23/n: But how, you may now ask, can we leverage this knowledge for improved patient treatment? Excitingly, several DBS centers world-wide have started to explicitly increase the stimulation impact on these tract models to optimize treatment benefit.
1
0
6
1/20. First things first: A 💜felt shout-out to
@NingfeiL
, my one-in-a-million partner in crime throughout all the highs & lows, & to our fantastic mentor
@andreashorn_
for guiding us with wisdom & patience! This project wouldn’t have seen the light of day if it weren't for them!
1
2
5
Huge shout-out to all co-authors for their valuable input and collaboration:
@BaldermannJC
,
@KibleurA
,
@SvenjaTreu
,
@HarithAkram
,
@Bassam_Al_Fatly
,
@The_Strange_Lab
, Juan Barcia, Ludvic Zrinzo, Eileen Joyce, Stephan Chabardes,
@VVV_Cologne
, Mircea Polosan, Jens Kuhn, &
@AA_Kuehn
0
0
5
Fantastic, user-friendly tool with the brilliant mind of
@simonoxen
behind it! Highly recommended!
Test-driving
@simonoxen
's WarpDrive tool to register a brainstem specimen to MNI. I honestly think this tool will transform precision neuroscience as we know it. Still some work to do but getting there.
@NingfeiL
@b_hollunder
@LLGoede
@Bassam_Al_Fatly
@qiangwangdr
@3DSlicerApp
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0
1
5