Andreas Horn
@andreashorn_
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Former account – Now at @andreashorn.org on bluesky. https://t.co/pohTcnIvXN
Joined November 2013
Dear friends – today’s the day: Andy’s leaving twitter!. It was so much fun to be here and I will miss part of it. However, this platform also changed so much that it is sometimes hard to recognize any longer. Lot’s of momentum at @bluesky – moving over there. A last thread 🧵
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Thrilled to share our work on DBS for #Alzheimer’s Disease . – likely the most important work in my career, so far. Spearheaded by the one and only @sofiari91 w/ lots of collaborators, we sought out to find the optimal DBS stim site & network in AD. A 🧵
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Beautiful atlas of brainstem nuclei released by the team of @BianciardiMarta @MGHMartinos!. 31 brainstem nuclei labels (8 medial/23 bilateral), and 11 brainstem subnuclei labels (bilateral).
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Very excited to announce our book on Connectomic Deep Brain Stimulation is out for preorder here:. w/@foxmdphd @AndreaKhn1 @HarithAkram @richardfbetzel @jmacshine @ThijsDhollander @neumann_wj @jclauneuro @shansiddiqi @DembekTill @eduardo_alho @BaldermannJC
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6 months after moving to the US and I already won an Oscar* – I love this country!. *less importantly: also got appointed Assoc. Prof @harvardmed and received an R01 from @NIMHgov 🙏
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I got a major grant and will start my own lab in Berlin – yay! We have a homepage now – yay! More importantly, we're looking for a talented 3-year PhD applicant with transitional 1-year Postdoc phase from now on! Would you be so kind to retweet? Thank you!
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Excited that our article 👇👇 has been featured on the cover of the march issue of @NatureNeuro – even more excited that @b_hollunder, the first-author of the study, hand-drew the cover herself. [🤫 I think she’s an artist].
Intrigued to discover more about how DBS reveals & therapeutically impacts on the dysfunctional circuits behind different brain disorders, from OCD to dystonia? 🪄🧠. So were we! Join us on this deep dive from core to cortex – now out @NatureNeuro: A 🧵
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Excited to be recognized with the @brainstimj @ElsevierConnect Early Career Award 2025! Big thanks go out to the fantastic individuals in my lab without whom none would be possible!. See you in Kobe – who else is coming?. @Brain_Circuits @netstim_org .
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Delighted to share our review on connectomic DBS for OCD spearheaded by @BaldermannJC out in @BiologicalPsyc1 now. This is likely the most significant clinical-translational achievement I've had the privilege to play a part in, yet. A thread:🧵
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Excited to announce that I will join the faculty of the Center For Brain Circuit Therapeutics led by @foxmdphd, @BWHNeurology w/ @tracytbatchelor as well as @MGHNeurosurg/@MGHNeurology w/ @RMarkRichardson, @ToddMHerrington & @MeritCudkowicz this September!.
We are excited to announce the addition of Andreas Horn, M.D., Ph.D. @andreashorn_ , a world expert in using brain circuit imaging, as new faculty member to the Center for Brain Circuit Therapeutics at Brigham and Women’s Hospital @foxmdphd. Read more
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Our commentary “Bringing human brain connectomics to clinical practice in psychiatry” by @shansiddiqi & @foxmdphd is now online, a sharable link w/ free access is here: .
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Humbled & grateful to be awarded the most important early career prize in Germany by @dfg_public & @BMBF_Bund. Many thanks go to my mentors @AA_Kuhn & @foxmdphd, as well as the amazing team @netstim_org without whom none of the work would have been possible or thinkable. 🙏 🙏.
Dr. Andreas Horn von #CharitéBerlin & @Harvardmed ist als einer von Deutschlands herausragenden Nachwuchsforschenden von @dfg_public mit dem Heinz-Maier-Leibnitz-Preis ausgezeichnet worden. Herzlichen Glückwunsch! 💐
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Fantastic, authoritative & comprehensive ‘roadmap’ article out in @NatRevNeurosci by Segobin et al. about in vivo segmentation of the thalamus.
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Super excited that our dysfunctome paper is finally out at @NatureNeuro! . Certainly by far the most important work I have been involved in so far. Huge congratulations and kudos to @b_hollunder and @NingfeiL for seeing this through. Fantastic tweetorial by Barbara below 👇👇
Intrigued to discover more about how DBS reveals & therapeutically impacts on the dysfunctional circuits behind different brain disorders, from OCD to dystonia? 🪄🧠. So were we! Join us on this deep dive from core to cortex – now out @NatureNeuro: A 🧵
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Excited about this ‘review of all reviews’ about thalamic DBS for tremor by @c_neudorfer. In a new tour de force article, Clemens covers … 🧵1/N.
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Nice tour of @intel museum: magnetic core memory - 1968 - made by hand in a time consuming process.
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Excited that our Connectomic DBS for Alzheimer's Disease is online at @NatureComms since today!. Paper here:. Tweet summary (based on the preprint) here:
Could brain stimulation help treat #Alzheimers disease? A research team at #CharitéBerlin has discovered a brain network that improves symptoms when stimulated. The study in @NatureComms paves the way for further studies. @andreashorn_ @sofiari91
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Happy to announce I have taken up an Associate Editor position at Human Brain Mapping @OHBM w/ EiCs @INM7_ISN @Frangougroup @gary_egan & J. Lancaster. Consider sending us your connectomic deep brain stimulation & neuromodulation work going forward! 🚀.
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Are you a neuroimager interested in the basal ganglia? Got 15 minutes time?.The #preprint of my talk at @OHBM is online:. Part of session “Neuroanatomy for Neuroimagers” w/ @jmacshine @sofievalk @CaseyPaquola @MaedbhK
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To treat OCD, Deep Brain Stimulation to the ventral capsule is effective – but the optimal target site remains unclear. In a huge collaborative effort @garance_meyer & @c_neudorfer set out to determine it @BiologicalPsyc1. A 🧵 👇👇.
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Our book "Connectomic Deep Brain Stimulation" will hit the shelf in ten days (September 17th) and can be preordered on @amazon or w Academic Press. In case you wonder whether it's worth it, you can read about the back-story and team behind the book here:.
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Since 2014, we’ve created and validated six structural and functional “average” connectomes of the human brain within #MNI space that are all freely available for download. A summary here:
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Excited that around 500 copies of our Connectomic Deep Brain Stimulation book sold. You never know how books go and not a high absolute number but given the size of the field very happy we pulled this off and motivating for a 2nd edition. 🙏🙏 everyone!.
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Commentary out by @shansiddiqi w/ Joe Taylor & @foxmdphd on how we could bring human brain connectomics into clinical practice in psychiatry (imho directly translatable to neurology).
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“data does not match what we know from rodents”. What is it with the obsession of rodent work in these high impact journals? I get that mice are cute but some of us aim at helping patients.
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@LitvakVladimir Hi Vladimir, thanks for the interest! I had to prerecord the talk for OHBM and it is here: Not exactly the same talk as the live one but v close. Miss you!.
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Toward Personalized Medicine in Connectomic Deep Brain Stimulation?. New #preprint @arxiv by the one and only @b_hollunder! A thread 🧶. w/ @NaN_Value, @shansiddiqi, @carstenfinke, @AA_Kuhn, @HMayberg, @foxmdphd, @c_neudorfer:.
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Super excited by this booklet by Wendell Krieg from 1957. Flicking through the colorful plates, it could have been published yesterday – but is indeed 65 years old. Human brain in the front pocket, rodent brain in the back pocket. Original price $7, copy from the U Birmingham.
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This is BOLD. 👇👇.
The most part of our blood is diamagnetic oxygenated haemoglobin which is repelled by a strong magnetic field [full video:
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The importance of this paper cannot be overstated – variance goes down if surgeons see more details. Unique cohort of cases operated following 3T/7T imaging: 7T cases do better! See lower variance in panel B. Always dreamed of achieving that w/ @leaddbs, Erik now did so w/ 7T!
First study exploring the impact of 7T vs 3T MRI on DBS outcomes for tremor: Our study shows 7T offers superior precision, improving tremor reduction & requiring lower stimulation current! @TheJNS @MayoRadiology #MayoClinicFlorida 🧵 .
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Very happy to have been working with @foxmdphd on a review about connectomic deep brain stimulation now out in @NeuroImage_EiC.
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Very excited that our study spearheaded by @NingfeiL has been published at @NatureComms! .In a highly collaborative effort involving people from five centers and 50 DBS patients we may have found a tract target to help patients suffering from OCD. 1/n.
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Beautiful footage by the Hassler book which shows what I keep preaching over and over again: “what dwarves we have become since the introduction of MRI” – ping @Haber_Lab . Knew many of the Hassler papers but this is a true gem, thanks @NaN_Value for sharing!
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Fantastic news that the Morel atlas has been made openly available by the authors – and they reached out to let us know we can integrate it into @leaddbs, as well!.#OpenScience 💪
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As a consequence of the debacle that @ElsevierConnect put upon our field with @NeuroImage_EiC (-> now @ImagingNeurosci), I am doing the little I can to sanction their actions by resigning as editor from their newly found journal “Deep Brain Stimulation”. 🧵👇
All NeuroImage and NeuroImage:Reports editors have resigned over the high publication fee, and are starting a new non-profit journal. This comes with great regret, and a huge amount of thought and discussion- please read announcement to get more details.
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Seeing the peer review process as a coauthor at @Nature - seems ridiculously hard to get human data published at the outlet. Key reason for rejection after three rounds of revisions given by editors was … wait for it 🐁
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Looking for a post-doc/engineer at @BrighamWomens @MassGenBrigham w/ appointment at @harvardmed. A dream come true could be someone experienced in @3DSlicerApp development and/or similar experience in neuroimaging. Experience with @leaddbs is a plus. Please RT for reach! 🙏
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Taking the excellent article by Suzanne Haber, @yendiki.and @SaadJbabdi in BioPsych as an opportunity for a thread:. “The dMRI tractography streamlines labeled as the slMFB represent fibers of the Internal Capsule, not the MFB.” . I could not agree more.
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3-year post-doc position in our lab (@ChariteBerlin) to work on #connectomic #deepbrainstimulation research using @leaddbs. Please RT for reach, thank you! 🙏. See our philosophy / labmanual here:
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Huge congratulations to @foxmdphd for receiving the @brainstimj early career investigator award today in Charleston at #BrainStimConf!. Using causal links (lesions & brain stimulation sites) to study their impact on the human connectome.
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Nice combination of DBS, optogenetics & high-speed membrane voltage fluorescence imaging to confirm that DBS creates an informational lesion. @NatureComms . Does it matter whether it’s a “white matter -” or “grey matter effect”? Why should it? 🤷♂️💁♂️.
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Very excited about this new work by @c_neudorfer et al. since we believe it could actually change clinical practice for thalamic DBS for tremor. How? Read on. w/ @daniel_krnbrg, @Bassam_Al_Fatly, @LLGoede, @ToddMHerrington, @EMiddlebrooksMD, @AA_Kuhn .
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Thanks for the fantastic feedback on our paper, everyone. We are over the moon! 💫. In case you are interested but you lack the time to read the entire thing, we wrote a one-page summary for @NatureNeuro that is freely available here:
Intrigued to discover more about how DBS reveals & therapeutically impacts on the dysfunctional circuits behind different brain disorders, from OCD to dystonia? 🪄🧠. So were we! Join us on this deep dive from core to cortex – now out @NatureNeuro: A 🧵
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We are thrilled to have received a center grant to retune brain disorders using deep brain stimulation under the lead of Andrea Kühn and Jens Volkmann in Berlin & Würzburg. This means, I’m hiring, as well - follow this place for more info.
#CharitéBerlin koordiniert neuen Sonderforschungsbereich .zur #Neuromodulation: Durch gezielte #Hirnstimulation sollen neuronale Netzwerke beeinflusst und so die Behandlung von #Bewegungsstörungen verbessert werden. @Uni_WUE @dfg_public.
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Quite excited about this one: Effective STN- and GPi-DBS in Parkinson's Disease is associated with modulating a shared functional network. New preprint by @KSobesky w/ @LLGoede @VOdekerken @qiangwangdr @NingfeiL @Bassam_Al_Fatly @AndreaKhn1 et al. 1/n.
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Beautiful work by the Bern group essentially validating the VTA model of Lead-DBS and using it to predict DBS outcomes using tractography. Interesting side note: normative tracts superior to patient-specific.
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We’re looking for an RA and Postdoc to join our network neuromodulation (deep brain stimulation & connectomics) lab at @MassGenBrigham & @harvardmed as soon as possible! . Please reach out via email or DM and please RT for reach! Thanks!. RA post here:.
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Dear DBS colleagues – consider submitting to Deep Brain Stimulation, the newly minted official journal of the @dbssocietyorg!. We are positive that we can almost certainly wave publishing fee for all submissions in 2023 – don’t hesitate to reach out if in doubt. 👇👇
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Excited to be recognised as one of the top ten projects in the Life Sciences category of the #FallingWalls #GlobalCall24! .Now in the running for the #ScienceBreakthrough of the Year title. #ScienceSummit24. Read more:
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Very much looking forward to @OHBM 2023 in Montreal and honored to give a keynote about how we can use neuromodulation to study the human connectome there. Who else is going? . @Brain_Circuits @BWHNeurology @netstim_org @Retune_CRC.
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Important editorial in @nature on discontinued support for Neuro technological devices. Abandoned: the human cost of neurotechnology failure
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Excited to complement @NingfeiL's @NatureComms paper on a structural connectivity target for OCD-DBS now by functional connectivity analyis out in @BiologicalPsyc1 @SOBP. Amazing work spearheaded by @NingfeiL and @b_hollunder – a 🧵 summary 1/n.
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Excited that I could acquire a first edition of Wendell Krieg's amazing functional neuroanatomy book – amazing foresight of visualizing tracts in 3D around 1942.
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Amazing welcome reception by the center for brain circuit therapeutics in Boston today, thanks so much @foxmdphd @neuromichael et al - @c_neudorfer and I are beyond thrilled to start working with such an amazing group of researchers!.
So happy to extend a wellkommen today to @andreashorn_ and @c_neudorfer. We're thrilled to have them join the Center for Brain Circuit Therapeutics team at @BrighamWomens. #medicine #science #neuroscience #neurology #hms #bwh #mgb
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Interested in neuroimaging in the context of deep brain stimulation? Maybe this introductory chapter about the specific challenges is for you. (MRI sequences, advanced registration methods, meaningful DBS models). w/ @simonoxen @NingfeiL.
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Great overhaul of the ever-reproduced three-loop figure by @Bassam_Al_Fatly for our upcoming book Connectomic Deep Brain Stimulation. Added somatotopy in the motor loop! Did we make any mistakes?
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Excited to see my entire newsfeed celebrating this. I think this could turn out to become the historical „NeuroImage event“ that changed publishing in the Neuro community. @ElsevierConnect @WileyNeuro @SpringerNature take note!
All NeuroImage and NeuroImage:Reports editors have resigned over the high publication fee, and are starting a new non-profit journal. This comes with great regret, and a huge amount of thought and discussion- please read announcement to get more details.
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The biggest ever upgrade to @leaddbs in its history – out now, read all the news in our newsletter below: 👇👇.@NingfeiL @NaN_Value @simonoxen @garance_meyer @oprienrico @j_achtzehn @c_neudorfer @laurenhart098 @b_hollunder @TriciZvar @HelenFriedrich_ @Kav_Fernando @GilmoreGreydon.
🎊🥳Lead-DBS v3.0 is finally out!.Read all of it in our newsletter which is currently being delivered to >7000 dear colleagues on our mailing list. New logo, new @BIDSstandard, new tools, new atlases, new everything – way too many people to thank! 👏👏🎉.
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Fantastic work by @NicoleProvenza & @SameerShethMD that may lead to a physiomarker in DBS for OCD out in @NatureMedicine: @leaddbs @DBSThinkTank.
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So far probably the coolest study I've been involved in just published in #BioPsych. In it, Carlos Baldermann delineates a tract that – if stimulated with DBS – improves symptoms of obsessive compulsive disorder. 1/n.
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Looking forward to participating in this @NIH workshop about human data & causality gap within in two weeks. Fantastic lineup w/ @DaniSBassett @dora_hermes @LucinaUddin @SuthanaLab @foxmdphd @shansiddiqi @SameerShethMD @MillerLabMIT & more – register free:.
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Thrilled, humbled but also intimidated by the impact of Lead-DBS since we started as a small weekend project in 2012. Now >20k downloads, >350 citations, >3,500 amazing colleagues on our mailing list. 👏to @NingfeiL, @DembekTill, @simonoxen, @oprienrico, @sofiari91 & many more!.
At least 72 publications empowered by @leaddbs in 2020!.Thank you so much to this great & welcoming DBS community & for the many contributions by labs worldwide. Thanks @qiangwangdr & @sofiari91 for keeping track!.
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Very excited to be the imaging side-kick on this review with two electrophysiology legends (@AA_Kuhn and @neumann_wj) where we argue that DBS should be seen as a brain circuit intervention and what we can do on multiple scales using ephys & imaging to study it! 👇👇
Our review article with @andreashorn_ and @AA_Kuhn on #deepbrainstimulation is out in @TrendsNeuro today! We discuss the interaction of brain circuit alterations and DBS effects in movement disorders and share our perspective on future opportunities.
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Excited to serve on the editorial board of a new journal entitled “Deep Brain Stimulation” - let’s get this started 👏👏 - now accepting submissions: Official journal of @dbssocietyorg.
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Was super honored when @StanDehaene asked me to contribute a picture to his book – now even more happy to receive a signed copy. Thank you! – and what a fabulous book with so many beautiful landmark contributions – A story of neuroscience in aesthetic pictures – much recommended!
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🚨#preprint alert 🚨 @Brain_Circuits . GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… . 🧵
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Excited that @simonoxen’s Lead-OR toolbox paper has been published w/ @eLife today. Much has happened till the preprint so here’s a renewed tweetorial about Lead-OR:.
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The first time I see my entire lab in a single space. Truly amazing moment after working across the Atlantic together on so many joint projects. Grateful for the @dfg_public Heinz-Maier-Leibnitz Prize money to make this possible!.
Together at last – after 2 years of transatlanticism we finally got (almost) all together at @BWHNeurology @harvardmed here in Boston as a united lab!
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New review on technological advances of DBS now out in @NatRevNeurol: . @MRCBNDU @DrNirLipsman @leaddbs
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Thanks to baby number 2 (and @neuromichael) I get to investigate the only true meaning of the acronym “DBS” one more time. 🥰
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Another figure I've been working on for the upcoming connectomic DBS book I'm editing. You can almost see the compression of the convolutional neural network of the striatopallidofugal system at work in these gorgeous PLI slices by Markus Axer et al.
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First paper describing the Franco-German 11.7T Iseult scanner out in @naturemethods. While the image comparison figure is certainly a strawman (I’ve seen much better images acquired at 3 and 7T), this is still a fascinating technical advance:.
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Somehow all I’ve done in the ~12 years of my career pointed towards this very study. When @NaN_Value came along it was finally possible to carry it out. Super happy that it’s out - and we hope this will have a true impact on how we apply DBS, in the future! A thread below:.
Modulating networks using DBS is an effective treatment for PD – but which circuits map to improvements in individual symptoms such as tremor, bradykinesia, rigidity, and axial? A 🧵 about our new paper out now in @NatureComms @netstim_org
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Nothing against nominating Biden and Harris for persons of the year, but my true heroes are these two.
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Amazing book from 1850 by Alfred Smee. “man is made up of a great number of voltaic elements, so arranged as to form one whole”. Human circuit with an extra layer to aggregate impressions from senses. *Way* ahead of his time. Via @matthewcobb's excellent The idea of the brain.
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Another gem shared w/ me by @c_neudorfer – drawings by Bertrand Luys (the one who first described the subthalamic nucleus). Isn’t that an amazing amount of artistic talent, clarity and beauty?
Thanks so much to @c_neudorfer for digging up this book by Sem-Jacobson from 1968 (!) which shows STN-DBS for PD and Cg25-DBS for Depression were pioneered in Norway, long before they became mainstream. More about this w/ @EspenDietrichs at @stimbrains:.
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Important paper by @qiangwangdr out @NeuroImage_EiC comparing patient-specific connectivity with normative connectomes in deep brain stimulation. w/@HarithAkram @muthu100680 @SameerShethMD @simonoxen @FangChengYeh @segroppa @Vanegas4Nora @NingfeiL et al.
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A bit annoyed by people being annoyed by Elon Musk. Let the guy do his thing. He’s not wasting public money. Nay-sayers have not been helpful in the history of discovery, ever. Why does our field feel threatened? This is not a race, it’s a joint endeavor - everyone can take part.
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Finally got a print copy of @BergmanHagai’s excellent book!. If you can’t yet decide whether you’d want to buy it (you should), read my review here:
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Great success for the team of @AA_Kuhn & @jan_roediger @ChariteBerlin showing non-inferiority for automated DBS programming using StimFit on top of @leaddbs electrode reconstructions in a randomized prospective clinical trial – out @LancetDigitalH! 🎉🎊💥.
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Preprint: Modulating the human functional connectome using deep brain stimulation. We scanned 20 PD patients in the fMRI while deep brain stimulation was switched on vs. off, analysed changes of the functional connectome. @neumann_wj @me_julez.
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Exciting to have this group of fabulous future rockstars join me in joining the center for brain circuit therapeutics & @netstim_org . Recruitment is done, we’re an actually lab now! 👏👍🎈🎉
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Yet another beautiful paper by Clemens Neudorfer – this time on endovascular deep brain stimulation. Setting atlases from @leaddbs and @ComaRecoveryLab among others into context of the vascular system. Great win that Clemens joined our lab a few weeks ago!.
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This is amazing! The Amsterdam Ultra-high field adult lifespan database (AHEAD): A freely available multimodal 7 Tesla submillimeter magnetic resonance imaging database
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