Prof Scott Ayton
@ayton_scott
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Dementia Mission Head, Florey Institute, University of Melbourne. Director of Centre of Research Excellence in Enhanced Dementia Diagnosis.
Joined July 2011
š§ Meet our Editorial Board Member: Dr. Scott Aytonļ¼A leader in translational neuroscience, with pioneering work on ferroptosis, Alzheimerās disease, and biomarker discovery. š#Neuroscience #Ferroptosis #Alzheimers #Biomarkers #FOSjournal
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Neuroferroptosis in health and diseases ā a Review by Peng Lei, Tara Walker & Scott Ayton https://t.co/bXplrZGp37
nature.com
Nature Reviews Neuroscience - The brainās high lipid content, iron levels and oxygen metabolism uniquely predispose it to ferroptosis, an iron-dependent form of regulated cell death. In this...
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'Apolipoprotein E in #AlzheimersDisease: molecular insights and therapeutic opportunities' Abdel Ali Belaidi @AbdelBelaidi Ashley I. Bush, Scott Ayton @ayton_scott @TheFlorey #apoe
https://t.co/1VIyy0kRCu
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Does this look right to you? Let me take you down a rabbit hole to illustrate how a network of interlacing problems in Alzheimerās disease research ethics impacts our progress on this disease.
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Honored to be included on the highly cited list with such an impressive group of researchers
Prof Scott Ayton @ayton_scott, Prof Ashley Bush @bush_professor, Prof Colin Masters and Prof Chris Rowe have been named in @Clarivate's 2024 Highly Cited Researchers list ā recognised for their influence in mental health and dementia research. Read ā”ļø https://t.co/OKx1sYzt63
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Prof Scott Ayton @ayton_scott, Prof Ashley Bush @bush_professor, Prof Colin Masters and Prof Chris Rowe have been named in @Clarivate's 2024 Highly Cited Researchers list ā recognised for their influence in mental health and dementia research. Read ā”ļø https://t.co/OKx1sYzt63
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"These findings suggest that lowering iron with deferiprone is detrimental in Alzheimer disease"
jamanetwork.com
This randomized clinical trial investigates whether the brain-permeable iron chelator deferiprone slows cognitive decline in people with Alzheimer disease.
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Thanks to the "3D trial" researchers who committed to testing the iron hypothesis of AD in clinical trial. I'm saddened by the result, but there is so much we learnt. Iron is important for AD, but not in the way that we thought.
jamanetwork.com
This randomized clinical trial investigates whether the brain-permeable iron chelator deferiprone slows cognitive decline in people with Alzheimer disease.
In this randomized clinical trial, iron chelation with deferiprone accelerated Alzheimer disease progression. https://t.co/f45s0cia22
@ayton_scott @AmyBrodtmann @Amir_fzll @DrAnitaGoh @kalinowski20pav @yenyinglim @pmaruff @OlivierSalvado @AaronWagen @bush_professor
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šø Thank you to our 400+ attendees who joined us in-person and online this morning at 'Diagnosis and Treatments in a New Era for Dementia' ā with Prof @ayton_scott , Dr Rebecca @NisbetADlab, and A/Prof Nawaf Yassi. š½ļø Watch the recording here: https://t.co/3Ni6w8d92q
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Join our speakers Prof Scott Ayton @ayton_scott (Florey Dementia Mission Lead), Dr Bec Nisbet @NisbetADlab (Group Head), and A/Prof Nawaf Yassi to discuss 'Diagnosis and Treatment in a New Era for Dementia' š¤ š« Tickets selling fast! Register here: https://t.co/TNQLME4APL
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Join our panel discussion with The Florey's dementia researchers: 'Diagnosis and Treatment in a New Era for Dementia' Event available in-person or online. Register here: https://t.co/TNQLME4APL
#TheFlorey #dementia #DementiaActionWeek @dementia_australia @ayton_scott
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#DementiaActionWeek - thru the NHMRC CRE in Enhanced Dementia Diagnosis we interviewed people across Australia about their experiences of dementia diagnosis. From their questions we created season 1 of our podcast (co-hosted with @carmody_sarah) called 'Is this Dementia?' šš¾
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We interviewed scientists @ayton_scott @yenyinglim & specialists @AmyBrodtmann @Doctor_Samba Mark Yates Michael Woodward & GP Dimity Pond
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It's Dementia Action Week. Florey researchers led by Prof @ayton_scott are on a mission to make dementia preventable and treatable. From defining its natural history and pathology, to taking drugs to clinical trials, learn more about our research: https://t.co/8ECqECvkSN
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Iron chelator therapy deferiprone unexpectedly worsened #Alzheimers disease in clinical study at #AAIC24. āWe were assuming that the iron was bad. But now we have to revisit this," study leader @ayton_scott told me. Read more in my story for @endpts: https://t.co/9h1vQ9LXmE
endpoints.news
PHILADELPHIA ā Among the many mysteries of Alzheimerās disease is the role that iron plays. The metal is vital for transporting oxygen in the blood and producing energy from mitochondria, but ...
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Great work Alayna and team!
Our new paper explores the utility of mRNA encoded antibodies targeting tau in Alzheimerās disease. A promising alternative to conventional immunotherapy with the potential to reduce production costs and improve therapeutic outcomes. https://t.co/nWgTw1is9A via @braincomms
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Our new paper explores the utility of mRNA encoded antibodies targeting tau in Alzheimerās disease. A promising alternative to conventional immunotherapy with the potential to reduce production costs and improve therapeutic outcomes. https://t.co/nWgTw1is9A via @braincomms
academic.oup.com
Wongsodirdjo et al. report that messenger RNA encoding a conventional tau antibody and an intrabody can be delivered to mammalian cells and translated into
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Congratulations Pratishtha! I canāt wait to see what you discover!
Excited to be awarded the Royce Simmons Foundation Mid-Career Research Fellowship by @DementiaAus to continue my work on #dementia.
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Abstract submissions are now open for the Australian Dementia Research Forum 2024! The theme for the forum is 'Turning The Tide On Dementia'. Abstract submissions are open and will close on 31 January 2023. Visit:ā”ļø https://t.co/nE3kJ0CEg4 for more information #ADRF2024
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We are recruiting a full-time research assistant to the @NeuFlamLab at @TheFlorey. If you are passionate in neuroinflammation in ALS-FTD and looking for a future PhD career, please contact me. https://t.co/XksQ7Vl5If
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