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Andreas Puschnik Profile
Andreas Puschnik

@andreaspuschnik

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Developing new medicines against infectious diseases @Vir_Biotech πŸ”¬πŸ¦ πŸ§« | prev. group leader @czbiohub, PhD @Stanford, Fulbright @UCBerkeley, BSc @TU_Muenchen

San Francisco, CA, USA
Joined January 2016
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@andreaspuschnik
Andreas Puschnik
2 years
Sr. Research Associate, HIV:
job-boards.greenhouse.io
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@andreaspuschnik
Andreas Puschnik
2 years
Sr. Research Associate, Hepatitis B:
job-boards.greenhouse.io
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@grok
Grok
11 days
The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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@andreaspuschnik
Andreas Puschnik
2 years
We are looking for two SRAs in Virology with focus on HIV or HBV. If you have experience in cell culture/mol. bio, and are passionate to develop therapies against infectious diseases, check out these job opportunities. Located in our beautiful SF/Mission Bay HQ. Links below πŸ‘‡.
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@andreaspuschnik
Andreas Puschnik
3 years
One of the best virology conferences!!.
@brittaspen
Britt Glaunsinger
3 years
Applications are now open for the *spectacular* 2023 Viruses and Cells Gordon Conference in Spain. Limit is 200 registrants--will fill up quickly!!
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@andreaspuschnik
Andreas Puschnik
3 years
We have an open position for a PhD level scientist in virology. Great opportunity to be at the intersection of exploratory and translational biology with access to cutting-edge technologies and amazing colleagues.
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@andreaspuschnik
Andreas Puschnik
3 years
Terrific news! I am thrilled that our work at Vir contributes to efforts to address the world’s most serious infectious disease threats.
@Vir_Biotech
Vir Biotechnology
3 years
Vir is pleased to announce we have been awarded a @BARDA contract with an initial investment of approx. $55M, which also allows for potential total investment of up to $1B, to support pandemic preparedness for influenza/other infectious disease threats.
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@andreaspuschnik
Andreas Puschnik
3 years
I have an open position for a PhD-level scientist with focus on #HBV in my group. We will develop new tools to study the HBV life cycle and and aim to develop novel therapies. Join us @Vir_Biotech - lot of great science and wonderful colleagues!
job-boards.greenhouse.io
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@andreaspuschnik
Andreas Puschnik
3 years
Cool study by @CaretteLab and colleagues. Viruses+functional genomics are a great tool to probe the inner workings of cells.
@CaretteLab
Carette Lab
3 years
We found LYSET as a new component of the cellular machinery targeting enzymes to the lysosome. Deficiencies cause rare genetic disease and make cells resistant to viral infection. Collaboration with Braulke and Jabs labs.
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@andreaspuschnik
Andreas Puschnik
3 years
Welcome @CaretteLab! Finally!!! πŸ˜ƒ.
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@andreaspuschnik
Andreas Puschnik
3 years
If you know potential candidates at your institution who may be interested, please send them my way πŸ˜€. @TheOttLab @PlossLab @RiceLaboratory @msdiamondlab @vsv512 @WilenLab @jschoggins @memerman @BenGewurz @shah_ps @MollyOhainle @MehleLab @SesmaLab @Fdouam @EinavLab Thank you!πŸ™.
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@andreaspuschnik
Andreas Puschnik
3 years
Great opportunity to be at the intersection of basic and translational biology with access to cutting-edge technologies and amazing colleagues. Please apply, share or contact me if you have questions.
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@andreaspuschnik
Andreas Puschnik
3 years
I’m looking for a PhD-level scientist to join my research group @Vir_Biotech. We work on exploratory projects in molecular virology and virus-host interactions across multiple viral pathogens with the goal to uncover new therapeutic approaches.
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@andreaspuschnik
Andreas Puschnik
3 years
Could not have picked better keywords :).Congrats and thank you for the nice collaboration @sarasunshinebio @marcoyannic.
@marcoyannic
Marco Hein @marcoyannic.bsky.social
3 years
🚨 New #LoveVirology preprint:.This paper has it all: single cells, COVID, CRISPR & Sunshine!.We systematically characterize host factors of SARS-CoV-2 using Perturb-seq. Led by @sarasunshinebio, bringing together @JswLab, Joe DeRisi's lab & many others.1/
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@andreaspuschnik
Andreas Puschnik
3 years
Great to see this story finally out. It was started with my first research associate @czbiohub Ashley Ngo, who brought immense enthusiasm and dedication to the lab every day.
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@andreaspuschnik
Andreas Puschnik
3 years
Knockout or knockdown of these restriction factors greatly enhanced the number of AAV-transduced cells and transgene expression levels. We hope that these insights may contribute to new strategies to avoid viral vector silencing and thus enable more efficient gene therapies.
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@andreaspuschnik
Andreas Puschnik
3 years
We revealed components of the DNA damage response incl. the Fanconi Anemia pathway. We also found chromatin+transcriptional regulators, e.g. the histone methyltransferase SETDB1, which famously silences retroviral sequences, and MORC3 shown to restrict herpesvirus infection.
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@andreaspuschnik
Andreas Puschnik
3 years
The presence of anti-AAV NAb or capsid-directed cytotoxic T cells are well known. By contrast, the cell intrinsic barriers for optimal transgene expression are not fully understood. We performed CRISPR screens to analyze restriction factors that inhibit AAV transgene expression.
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@andreaspuschnik
Andreas Puschnik
3 years
Preprint alert 🚨: .#AAV vectors are one of the leading platforms for gene delivery for the treatment of human genetic diseases. Despite some clinical successes, AAV-based gene therapy still faces several challenges.
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biorxiv.org
Adeno-associated virus (AAV) vectors are one of the leading platforms for gene delivery for the treatment of human genetic diseases, but the antiviral cellular mechanisms that interfere with optimal...
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@andreaspuschnik
Andreas Puschnik
3 years
Great opportunity to work on hepatitis B and D viruses. Fantastic science and colleagues are waiting!.
@FLempp
Florian Lempp
3 years
We’re hiring a Scientist/Virologist to help develop novel medicines against #HBV and #HDV Please forward to potential candidates. #virology
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