Amrou Sarraj
@amrsarrajMD
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George M Humphrey II Endowed Professor, CWRU School of Medicine and UH Neurological Institute - Stroke Systems Director at University Hospitals
Cleveland, OH
Joined March 2012
Proud and honored to present @SELECT2Trial results at #ISC2023 EVT is safe and efficacious in large core! We’re a step closer to improving more patients lives.
nejm.org
Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations. We performed a prospective, randomized, open-lab...
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Article Commentary: “Association of Ischemic Core Hypodensity With Thrombectomy Treatment Effect in Large Core Stroke” In this #BloggingStroke post, @DrRamiMorsi discusses #Stroke article by @VYogendrakumar & Campbell et al. #AHAJournals
https://t.co/3aZPeD9H9y
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Check out the July Stroke alert podcast, highlighting important articles published in Stroke journal and a terrific discussion on the interpretation of large core trials. @StrokeAHA_ASA
ahajournals.org
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ICYMI: Check out the July episode of the #StrokeAlert Podcast. In this episode, host @NAsdaghi addresses these three questions. https://t.co/ytP6yMEUYy
@amrsarrajMD @NKrementzMD @CT_LP_MRI #stroke #AHAJournals #StayAlertWithStrokeAlert
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The pleasure is mine! Thank you @NAsdaghi @StrokeAHA_ASA for featuring our article. @TudorGJovin @XiaochuanHuo @lapergue6 @NguyenThanhMD @Fie0815 @oozaidat @ZhongrongMiao and all the wonderful PIs of large core trials. The ultimate data from individual patient data meta-analysis
An honor to host @amrsarrajMD on the podcast to answer many important questions on EVT for large core. Does age, hypodensity index, NIHSS and core size modify outcomes? What about thrombolysis if eligible @NKrementzMD @CT_LP_MRI @StrokeMiami
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Via @NEJM: Stroke patients given tenecteplase before thrombectomy had better outcomes than those who just had thrombectomy, possibly opening the door to more research on timing/delivery: https://t.co/s8wnqpRkXb
@AANMember @eva_mistry @amrsarrajMD @TudorGJovin @lrwechsler
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The July episode of the #StrokeAlert Podcast is now available. Host @NAsdaghi highlights articles in the July issue of #Stroke and interviews @amrsarrajMD on “Mechanical Thrombectomy for Large Ischemic Stroke.” #AHAJournals #StayAlertWithStrokeAlert
https://t.co/ytP6yMEUYy
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ESO's #PaperOfTheMonth: ESO's #PaperOfTheMonth for June is out: "Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomised Controlled Trials." https://t.co/R9gbrXOiZl
@amrsarrajMD @ZhongrongMiao @oozaidat @TudorGJovin
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Mechanical Thrombectomy for Large Ischemic Stroke: A Critical Appraisal of Evidence From 6 Randomized Controlled Trials https://t.co/Lf03j5qoQD
@StrokeAHA_ASA
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#STROKE: Review by @amrsarrajMD et al. of the six recent RCTs of thrombectomy in large core strokes with the exploration of what expanding eligibility could mean for stroke care systems and society. #ESOC2025 #AHAJournals
https://t.co/37TeNCb7MD
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Toughest lecture I ever delivered! Starting them young on #strokeawareness This @HathawayBrownn preschool crowd had a lot of interesting remarks. I definitely can see some future doctors in there! Thank you @PenNeuro for your support with the illustrative models.
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Not all hypodensity/ASPECTS is the same in large core. In SELECT-2, if ≥26 mL of brain tissue has ≤26 HU (severe hypodensity), there may be no benefit from EVT in large core patients & increased complications @NguyenThanhMD @amrsarrajMD @StrokeAHA_ASA
ahajournals.org
BACKGROUND: We aimed to determine whether extensive severe computed tomography (CT) hypodensity, representing blood-brain barrier injury, would be associated with a reduced benefit of endovascular...
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Women Benefit Equally From Endovascular Thrombectomy for Large Core Ischemic Stroke in a Subanalysis of SELECT2 In this #BloggingStroke post, @drchloemutimer discusses #Stroke article by @JPTsaiMD et al. #AHAJournals #GoRedForWomen
https://t.co/uzXXexw67m
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#ISC25 Session Report: Pushing the Limits of EVT in 2024 #BloggingStroke contributor @GregoryJWongMD shares highlights from “Wild Wild West: Frontiers of EVT – Large Core, Mild and Distal Occlusions.” @amrsarrajMD @TudorGJovin @mayank_G0 @AHAScience
https://t.co/dsvr7vZgoE
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So delighted to see Sex based analysis from @SELECT2Trial on @StrokeAHA_ASA cover page!
#Stroke February Cover Figure: In a post hoc analysis of the SELECT-2 trial, both biological sexes enjoyed equal benefit from EVT in the setting of established large core infarction. #GoRedForWomen #AHAJournals
https://t.co/yMsctJYEBK
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#Stroke February Cover Figure: In a post hoc analysis of the SELECT-2 trial, both biological sexes enjoyed equal benefit from EVT in the setting of established large core infarction. #GoRedForWomen #AHAJournals
https://t.co/yMsctJYEBK
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Proud of our PGY3 resident Ameena Shafiq for her work demonstrating no heterogeneity of association between functional outcomes and direct-to-angio suite vs repeat imaging approaches among patients who did and did not receive thrombolysis from the Direct to Angio cohort study.
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Happening now in #strokeintherealworld at #ISC25 - large core clinical trials review with @amrsarrajMD
@AHAScience @StrokeAHA_ASA @NEJM @SELECT2Trial
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Let’s admire the power of mechanical thrombectomy in stroke patients seen in this analysis from SELECT-2. Only 62 patients were included with large core & tandem lesions ASPECTS 3-5: OR 4.5 for independent ambulation & 2.5 for mRS, p<0.05. @amrsarrajMD
neurology.org
Background and ObjectivesAlthough previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most of them excluded patients with...
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