RT @oriol_pich: 🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related bloo….

RT @hi_stem_lab: 🚨 Paper out in Nature 🚨.Amazing news from the Trumpp Lab @HI_STEM_lab performed by Vera Thiel @VT199104, Simon Renders @S….

RT @const_ae: After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳. LEMUR is a t….

I'm very thankful to everyone involved in the study! The project would not have been possible without my co-firsts @KfdG_1236 and @hyobin_jeong and co-lasts Andreas Trumpp, @JanKorbel5 and @ash_d_sanders 🍾🎉🥳 5/5.

In another patient with paired pre- and post-treatment samples, two distinct subclones persisted post venetoclax-based treatment. Both had subclone-specific mechanisms to further resistance: a shift toward MEP-like cells and NF1 loss. Go and read more about the other cases! 📜4/5

For example, in one patient the sublclone driving relapse had a seismic amplification, upregulated DNA damage response and it also engrafted in mice. We could even see cell-to-cell differences in the copy-number states of the seismic amplification! 🌋3/5

We integrated single-cell resolution structural variants, nucleosome occupancy, gene expression and surface proteins to study subclonal growth patterns in complex karyotype AML patient samples 🧬 2/5

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet ! 🎉👩🏻‍🔬. They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5.

RT @const_ae: There's a lot of excitement about foundation models and their ability to learn biology 🧬💻. But current tools for perturbation….

RT @AlexWaclawiczek: Interested in the "Arms-Race" against therapy resistance in Acute Myeloid Leukemia? Read our perspective just publishe….

RT @const_ae: Just uploaded a new version of the LEMUR manuscript.🎉🥳.LEMUR disentangles observed and latent factors….

RT @hi_stem_lab: Excited to announce: International Heidelberg Symposium on Stem Cells and Cancer on Sep 10-12, 2023 @DKFZ. Worldwide opini….

RT @const_ae: Incredibly proud to see our benchmark of single-cell preprocessing methods finally published 🥳🥳🎉. We show that despite its th….

Thrilled to share some of the exciting results from my PhD from an amazing collaboration with @AlexWaclawiczek @SimonRenders at Trumpp Lab @hi_stem_lab 🎉🎉.