Immunotherapy a key to fight aging? We break down our recent study in this animation! 🧪 Immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! .@JuliaMMagdalena.@KrizhanovskyLab

We live once, but we don't have to die once.

RT @UriAlonWeizmann: Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M….

RT @JuliaMMagdalena: The power of Longitudinal studies for comprehensive view of physiology and pathology. How pregnancy changes our body?….

RT @YosefLab: Last sunset before we kick off #SCG24! .Truly excited to engage with the global single cell family. Wondering about what Harr….

RT @NatureCellBio: 📑: @JuliaMMagdalena @amitmechaging et al fr/@KrizhanovskyLab show that p16-expressing senescent cells enhance the stabi….

RT @AgingBiology: p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells.

RT @JuliaMMagdalena: Immunotherapy as an anti-aging treatment?.@KrizhanovskyLab we show that immune checkpoint anti-PD-L1 can enhance the i….

Our research opens up new possibilities for developing therapies that target senescent cells, potentially delaying the onset of age-related conditions and improving overall healthspan. #healthspan #futureofaging #longevity #.

But here's the exciting part: we found that by targeting PD-L1 with specific antibodies, we can remove these "invisible" senescent cells! A step forward to fight against age-related diseases. 💪 #immunotherapy #antiaging

An increase in p16 disrupts the ubiquitination of the PD-L1 protein, affecting its degradation rate and resulting in higher levels of PD-L1 protein on the senescent cell. #p16 #ubiquitination #PDL1 #senescence.

This increased PD-L1 stability is driven by a protein called p16, a key marker of senescence. So, p16 not only controls cell cycle arrest but also helps senescent cells evade immune-surveillance! 🤯#p16 #PDL1 #immunesurveillance.

We discovered that senescent cells have a survival-mechanism up their sleeve: they increase the stability of a protein called PD-L1. This protein acts like an "invisibility cloak," hiding senescent cells from the immune system. 👻 #immunesystem #PDL1.

Aging is a complex process, and one of its hallmarks is the accumulation of senescent cells. These cells, while once healthy, have become damaged and dysfunctional. But why do they stick around? 🤔 . Our new research sheds light on this! #aging #senescentcells #aging.

RT @KrizhanovskyLab: Congrats @JuliaMMagdalena @amitmechaging . Thanks @UriAlonWeizmann for great collaboration.

RT @deniswirtz: Morphological features of the skin can predict aging with a mean absolute error comparable to state-of-the-art epigenetic c….

RT @AgingBiology: Quantifying the stochastic component of epigenetic aging.

RT @KrizhanovskyLab: Congratulations @NRachmian for this elegant study on senescent microglia in Alzheimer's disease published at @NatureNe….

RT @schumacherbj: Judy will always be remembered as scientific giant who pioneered the senescence field. Her conceptually transformative wo….