Immunotherapy a key to fight aging? We break down our recent study in this animation! 🧪 Immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! https://t.co/KIdDoxwgRF… @JuliaMMagdalena @KrizhanovskyLab

Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its

We live once, but we don't have to die once.

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional), we mapped week-by-week changes starting from preconception to months-long postpartum recovery.

The power of Longitudinal studies for comprehensive view of physiology and pathology. How pregnancy changes our body? Can systemic inflammaging precedes cancer diagnosis? Check out below.. https://t.co/2B2PMzLGdG https://t.co/NKQ5MrGZXe @UriAlonWeizmann @Mark M Davis

Last sunset before we kick off #SCG24! Truly excited to engage with the global single cell family. Wondering about what Harreman, Nativ and CytoVI mean? Come by our posters!

📑: @JuliaMMagdalena @amitmechaging et al fr/@KrizhanovskyLab show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1, by downregulating its proteasomal degradation to accumulate in ageing and chronic inflammation. https://t.co/rbqPzfKSiM

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells https://t.co/O4H4VqaDSH

Immunotherapy as an anti-aging treatment? @KrizhanovskyLab we show that immune checkpoint anti-PD-L1 can enhance the immune system to remove senescent cells & ameliorate age-related phenotypes! @amitmechaging @UriAlonWeizmann @IdoAmitLab @WeizmannScience https://t.co/LrkXGBd7uN

https://t.co/67LxugweVY

Our research opens up new possibilities for developing therapies that target senescent cells, potentially delaying the onset of age-related conditions and improving overall healthspan. #healthspan #futureofaging #longevity #

But here's the exciting part: we found that by targeting PD-L1 with specific antibodies, we can remove these "invisible" senescent cells! A step forward to fight against age-related diseases. 💪 #immunotherapy #antiaging

An increase in p16 disrupts the ubiquitination of the PD-L1 protein, affecting its degradation rate and resulting in higher levels of PD-L1 protein on the senescent cell. #p16 #ubiquitination #PDL1 #senescence

This increased PD-L1 stability is driven by a protein called p16, a key marker of senescence. So, p16 not only controls cell cycle arrest but also helps senescent cells evade immune-surveillance! 🤯#p16 #PDL1 #immunesurveillance

We discovered that senescent cells have a survival-mechanism up their sleeve: they increase the stability of a protein called PD-L1. This protein acts like an "invisibility cloak," hiding senescent cells from the immune system. 👻 #immunesystem #PDL1

Aging is a complex process, and one of its hallmarks is the accumulation of senescent cells. These cells, while once healthy, have become damaged and dysfunctional. But why do they stick around? 🤔 Our new research sheds light on this! #aging #senescentcells #aging

Congrats @JuliaMMagdalena @amitmechaging . Thanks @UriAlonWeizmann for great collaboration.

Morphological features of the skin can predict aging with a mean absolute error comparable to state-of-the-art epigenetic clocks. Download our paper here: https://t.co/2EoziOSUuS

Quantifying the stochastic component of epigenetic aging https://t.co/UEi8WiaWZK

Congratulations @NRachmian for this elegant study on senescent microglia in Alzheimer's disease published at @NatureNeuro. Exciting collaboration with Michal Schwartz and the first study from our lab on the role of senescence in neurodegenerative diseases.