Alex N Nguyen Ba
@alex_nguyen_ba
Followers
275
Following
69
Media
1
Statuses
67
Assistant Professor at the University of Toronto. Studying evolution and high-throughput quantitative genetics.
Cambridge, MA
Joined July 2018
RT @evoecolab: Increasing funding to #GradStudents and #Postdocs is the most urgent funding issue in Canada-they haven't had a raise in 20….
0
70
0
Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
355
635
2K
RT @angphilli: Thrilled to announce the Phillips lab is opening @UCSF in Sept! We’ll be developing high-throughput methods to examine how m….
0
29
0
Why do some mutations' effects seem to depend on starting fitness? We developed a Cre/Lox CRISPR gene-drive system ==> expanding gRNA array, to pop open the hood on 'global epistasis'. @cwbakerlee, @shulgina_kate, @jireva in @MichaelMDesai lab. Read here:
science.org
A genome-spanning fitness landscape reveals how idiosyncratic genetic interactions lead to global epistatic patterns.
0
10
26
RT @Co_Biologists: Apply for a funded, early-career researcher place at our in-person #BiologistsWorkshops ‘Genotype to Phenotype: Bridging….
0
8
0
RT @shulgina_kate: Today my paper with @ribosaur on new genetic codes comes out in @eLife! It's been a labor of love over the past five yea….
elifesciences.org
Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their...
0
90
0
RT @sudiptatung: My group at @AshokaUniv is currently looking for prospective Ph.D. students in #ecology and #evolution. Interested studen….
sites.google.com
Welcome to the website of the Integrative Genetics and Evolution Laboratory (IGEL) at Ashoka University, Sonipat, India. Sudipta Tung is the PI of this group. Here we integrate empirical and quanti...
0
41
0
Our work, and the monster SI, was a true tour de force by my amazing labmates (Katherine Lawrence and @arturrego_costa) and I. A great set of music playlists, costumes, beers and games pulled us through. Enjoy the preprint - we sure are glad this is out. 4/4.
1
3
9
We analyzed the pleiotropy and epistatic interactions amongst hundreds of QTL per environment from a single cross - highlighting how an interconnected cellular network propagates mutations to phenotype. 3/4.
1
1
3
Our goal was to approach the scale of GWAS studies that frequently observe these low effect variants, so we used high-throughput robotics and barcoding to sequence and phenotype 100,000 yeast segregants in a variety of environments. 2/4.
1
1
3
We developed an experiment to increase the scale of QTL mapping so that we may observe how 'low effect' variants play a role in determining phenotypes. 1/4.
Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast #biorxiv_genetic.
3
28
56
Anybody using an interactive/smart whiteboard that they are truly satisfied with for education/science communication purposes? Any recommendations?.
0
0
1
RT @asanchez_lab: Several immensely talented postdocs will be leaving our lab within the next year. I wanted to make it clear (to folks inv….
0
36
0
RT @FelixBarber9: Our new paper makes the surprising prediction that dividing asymmetrically could enhance the population growth rate of ce….
journals.plos.org
Author summary How rapidly a population of single-celled organisms can grow will strongly impact their long-term success. Prior work has shown that many factors impact this population growth rate,...
0
8
0
RT @sudiptatung: Excited to share our work on spontaneous whole-genome duplication (autodiploidization) in budding yeast, published in #G3j….
academic.oup.com
Abstract. Spontaneous whole-genome duplication, or autodiploidization, is a common route to adaptation in experimental evolution of haploid budding yeast p
0
11
0
RT @jsvanleeuwen: Now online, a study in collaboration with @LeopoldParts in which we asked how often natural variants can suppress delete….
embopress.org
image image A survey of ~ 1,100 temperature‐sensitive alleles of yeast essential genes in ten diverse strains shows that natural genetic variants frequently suppress deleterious mutations. Genetic...
0
16
0
RT @OdedRechavi: For a PhD student, choosing a good lab is 10 times more important than choosing a particular topic to study.
0
1K
0
RT @TanushJagdish: Local hospitals in and around Mysuru and my villages in India have run out of PPE and oxygen. My family is running a mut….
0
13
0
RT @taraneh_z: Very happy that our paper on identifying molecular features associated with function in disordered regions was accepted for….
elifesciences.org
A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
0
17
0
RT @biorxivpreprint: Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations .
0
20
0