Adam Bauer
@adamqbauer
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Associate Professor @WUSTLmed Neurophotonics | Brain Circuit Mapping | Post-Stroke Plasticity | Neurovascular Coupling
St. Louis, MO
Joined July 2020
Check out our paper in @Brain1878 investigating whether mGluR5 influences functional recovery after stroke. A fantastic collaboration with my dear friend @TadeuszWieloch, many @lunduniversity (Jakob, Miri, Karsten, Carin, Daniela), Ferdinando Nicoletti, Byungchan Kim, and others!
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#Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and neuronal and hemodynamic measures of brain function @adamqbauer @jordacular @realJoshSiegel @JonahPadawer @OliverK28 @xwang167 @washumedicine @WashUMedMIR
https://t.co/JXtKWdMCjP
nature.com
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
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The Biophotonics Research Center at WashU Radiology is hiring! We're looking for innovative scientists to join our dynamic and collaborative community. Interested in learning more about the environment and opportunities? DM for details! https://t.co/5oOqcCHnzg
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Delighted to share @xwang167 first paper - congrats! 🎉🎊🍻 Fantastic collaboration with @macauleylab, as well as @JonahPadawer @ZPRosenthal and others Spatiotemporal relationships between neuronal, metabolic, and hemodynamic signals in the mouse brain:
cell.com
Wang et al. use wide-field optical imaging to determine how neurovascular coupling (NVC) and neurometabolic coupling (NMC) relative to pyramidal neuron activity vary over the cortex and whether...
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Extremely excited that our symposium has been accepted for this year’s @AusNeuroSoc conference in Perth! Looking forward to seeing you all there and sharing our research as well as hearing all of the other presentations! 🧠 @dylanablack @LucyMPalmer @adamqbauer
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Neurophotonics calls for papers on Understanding Brain Disease with Live Imaging. 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐛𝐫𝐚𝐢𝐧 𝐝𝐢𝐬𝐞𝐚𝐬𝐞 and technology developments are welcome! Guest Editors: @adamqbauer, @BistraIordanova, @SN_Lab
#Neurophotonics #Neuroscience #fNIRS
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Check out the awesome tech coming out of @joe_culver and @adameggebrecht labs!
Prof. @joe_culver & Associate Prof. @adameggebrecht discuss their work advancing diffuse optical tomography, a noninvasive approach to brain imaging that uses LED light to create high-resolution images of the brain in its different stages. #MIRresearch
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Honored to be even mentioned in the same tweet as these fine folks! Proud to be part of @AcadRad and the wonderful environment at @MIRimaging @WUSTL @WUSTLmed
We're excited to announce that 4 MIR faculty have been named to @AcadRad Council of Distinguished Investigators for their outstanding contributions to medical imaging. #MIRresearch
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Check out our paper in @GeroScienceAGE examining how whole brain irradiation affects cognition and neuronal network organization! Wonderful collab w/ Stephanie Perkins, Ben Seitzman, @ReynosoFJ, Tim Mitchell, @CYuede @LabRubin & funds from @SitemanCenter
https://t.co/mUEo40ajsu
link.springer.com
GeroScience - Cognitive dysfunction following radiotherapy (RT) is one of the most common complications associated with RT delivered to the brain, but the precise mechanisms behind this dysfunction...
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Looking forward to having you here, Sayaka!
I am thrilled to announce that I will be joining the Department of Psychiatry at WashU @WUSTL @WUSTLmed as an assistant professor in early 2024! S Inoue lab explores how ovarian hormones modify neural circuits in the female brain to regulate behaviors throughout the lifespan.
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I'm pleased to announce that I'll be joining the Department of Radiology @MIRimaging @OpticalRadLab at WashU @WUSTL @WUSTLmed @WashUONR as an Assistant Professor in early 2024! I couldn't be more excited to join the amazing WashU neuroscience and imaging community. (1/4)
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Delighted to see @JonahPadawer's work using widefield optical imaging of calcium & hemodynamic activity in mice to determine if psychedelics (DOI) differentially affect neuronal vs. hemodynamic measures of brain organization (yep!) Awesome collab w/@realJoshSiegel & @jordacular !
We found a psychedelic (DOI) altered neurovascular coupling and differential changed neuronal⚡️📉 vs hemodynamic🩸 📈 brain activity 🧠. These findings have grand implications for interpretation of psychedelic fMRI. https://t.co/SWlTBDOG64
@realJoshSiegel @adamqbauer @jordacular
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We conclude that neuronal circuitry subserving sensorimotor function after stroke is depressed by a mGluR5-dependent maladaptive plasticity mechanism that can be restored by mGluR5 inhibition.
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Finally, mGluR5 inhibition after stroke prevented brain-wide disruptions in functional connectivity normally observed acutely after stroke - i.e., brain network organization in mice treated with MTEP after stroke was more similar to healthy mice
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Multisensory stimulation by enriched environments (EE) enhanced stroke recovery, a result prevented by PAMs, implying mGluR5 mediates EE-mediated recovery. The kicker - Inhibiting mGluR5 in conjunction with EEs provided an additive recovery enhancement compared to MTEP or EE!
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Recovery was evident within hours after initiation of treatment. Accelerated recovery was also observed following stroke in mGluR5 KO mice and prevented by positive allosteric modulators (PAMs) of mGluR5 in WT mice.
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The gist - treatment with negative allosteric modulators (NAMs) of mGluR5 (MTEP, fenobam, or AFQ056) for 12 days, starting 2 or 10 days after stroke, restored lost sensorimotor functions, without affecting infarct size (i.e., NAMs were not neuroprotective).
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