Sergio Perez Acebron
@Acebron
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Professor of Cell signalling & Genome stability at Heidelberg University and the #WNT SFB1324. Interested in signalling integration & stem cells. Tweets my own
Heidelberg
Joined October 2009
Can developmental signals shatter or mend our genomes? .Really insightful spotlight by Kyle M Loh regarding our recent publication:.
www.cell.com
Consensus holds that most cells in the embryo are genetically identical and have healthy genomes. However, embryonic cells with abnormal chromosomes are surprisingly frequent. In a recent publicati...
How does genomic mosaicism arise during development? We identified that embryo patterning signals not only readour genetic blueprints to build organisms, but they also play a critical role in their maintenance. A quick dive into our new paper 1/10
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Congrats Michael @mwdorr !.
Congratulations, Michael Dorrity!. The EMBL Group Leader has received the FEBS Excellence Award, which will provide €100,000 to support his research on molecular and cellular sources of robustness in development.
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RT @SteSantaguida: We are very excited to open the registration for the upcoming @EMBOevents on Chromosome Segregation and Aneuploidy in be….
meetings.embo.org
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
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RT @mayor_lab: Inspired by @_BSDB_ 's latest video? Help us promote our call to sponsor early-career researchers in Cell & Developmental Bi….
www.youtube.com
This is a 15-minute shortcut of our documentary, in which we showcase some of the beauty, as well as the translatability, of developmental biology research b...
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Far reaching work Manu, congrats!.
(1/n) Are you ready to plunge into depths of our oceans with us! This is the story of “hidden comet tails” & our discovery of how a crucial biological process across our planet can put brakes on carbon capture in our oceans. Latest in @ScienceMagazine
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RT @Michael_Boutros: Congratulations to Sergio Acebron and collaborators @sfb1324 for their publication showing how Wnt signalling prevents….
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Que pena no poder asistir este año a #NaukasBilbao24 veo por las fotos que está vibrante. Un abrazo a todas y todos los colegas que se lo están currando. Os veo la siguiente! Y de momento me quedo con los vídeos.
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RT @mayor_lab: Eddy De Robertis delivered an inspiring speech at the Spemann & Mangold Conference dinner in the stunning Historisches Kaufh….
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RT @mayor_lab: Excited about the list of incredible speakers for the 100th anniversary of The Organizer paper, plus many more outstanding t….
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Happy to have contributed to this cool study on the role of @WNT signals in the elusive tumorigenesis of the choroid plexus.
Thrilled to announce our latest paper published in Neuro-Oncology and our first paper on choroid plexus tumor!.Activation of Wnt/β-catenin signaling is critical for the tumorigenesis of choroid plexus | Neuro-Oncology | Oxford Academic ( (1/4).
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RT @SteSantaguida: POST-DOC POSITION AVAILABLE. Interested in understanding the role of chromosome instability and micronuclei in cancer de….
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Special shout-out to the first authors @Anchel_91 and @JaninaHattemer , AcebronLab members, @sfb1324 and collaborators: BastiansLab, @JBageritz @AlexandervanOu1 @Marta_Shahbazi @jervdberg @AndreiChabes and many other tweet-less. cc @UniHeidelberg 10/10.
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Many open questions: e.g., does misseregulaton of this process contribute to miscarriage or neurodevelopmental diseases? We would like to map the contribution of microenvironmental signals to genomic mosaicism and associated disorders during lifetime 9/10.
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Furthermore, we found that the neurogenic factor FGF2 induces replication stress-mediated chromosome missegregation during the onset of neurogenesis, which could provide a rationale for the elevated chromosomal mosaicism of the developing brain 8/10
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We show that #WNT and BMP signalling sit at the helm of this regulatory cascade by protecting cells from different sources of replicative stress. We found that these roles fade down during lineage specification into the three germ layers, but re-emerge in neural progenitors 7/10
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We revealed a dichotomy between signals inducing A vs P axis in gastrulation in inducing vs protecting from chromosome missegregation, respectively. Mechanistically, they regulate DNA replication in S-phase and chromosome segregation fidelity in the subsequent mitosis 6/10
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