Abhineet Ram
@abzzram
Followers
88
Following
21K
Media
22
Statuses
337
Joined November 2014
We used machine learning methods to tackle this unique dataset and learn about the underlying biology. In short, we created models that infer long/short term enzyme behavior using effector protein levels. This leads to improved methods to infer signaling history of fixed cells!.
1
0
1
Hi bio+ML folks! Check out our recent work modeling live-cell microscopy data with fixed-cell protein measurements. Here are cells expressing a biosensor of an enzyme, followed by multiplexed immunofluorescence staining of several proteins in the same cells. @BiologyAIDaily
1
3
7
Are you using phospho-ERK staining to infer Ras/MAPK signaling history of fixed cells? . Check out our recent work demonstrating how this can be misleading, and how to get more spatio-temporal information out of immunofluorescence staining.
nature.com
Nature Communications - ERK signaling involves complex spatiotemporal dynamics, making it difficult to quantify in many systems. In this study, live-cell activity measurements are combined with...
1
2
13
RT @paoloarmando83: Our review on apoptosis-induced ERK waves is out in Seminars in Cell & Developmental Biology! Thanks to @PertzL, @macdo….
0
4
0
RT @ArtemisConsort: The funny thing about this video is that everyone who actually knows the answer is saying “this is an interesting quest….
0
1K
0
RT @bsfarrington: I’m at a cancer treatment center getting my 27th dose of radiation. My doctor recommends 35. @UHC refuses to pay for more….
0
18K
0
I'll be giving my Ph.D. exit seminar this Friday, July 5th at 4pm PST. Please join via zoom if you're interested in learning about my dissertation research on modeling MAP Kinase signaling dynamics.
1
1
9
The preprint from my dissertation work is out! Working on the revisions now so keep an eye out for the final version! #ERK #MAPK @albecklab @InSiDE_Seminar
biorxiv.org
The Ras/ERK pathway drives cell proliferation and other oncogenic behaviors, and quantifying its activity in situ is of high interest in cancer diagnosis and therapy. Pathway activation is often...
3
5
15
Our 2-part review on ERK dynamics is out! It was great to highlight some of the amazing work done by the MAPK field, including @SantosLaB8 @PertzL @toettch @RegotLab @BugajLab, and many more!
portlandpress.com
Extracellular signal-regulated kinase (ERK) has long been studied as a key driver of both essential cellular processes and disease. A persistent question has been how this single pathway is able to...
3
4
22
RT @ucdvolkie: The family of Karim Najm, the UC Davis student who was fatally stabbed in Davis, has created an undergraduate research award….
give.ucdavis.edu
In memory of Karim Majdi Abou Najm
0
138
0
RT @tori_apodaca: This is Karim Abou-Najim. He is the victim in the deadly stabbing at Sycamore Park in Davis. Family friends tell us he wa….
0
763
0