RT @imbmainz: Dr @_SandraSchick has been awarded a Starting Grant from @ERC_Research. The grant will help propel the group's work to elucid….

If you would like to join the team, please get in touch. #chromatin #development #NDD #ERCStG.

Extremely honoured and excited to receive the @ERC_research grant. Big thanks to all involved, all supporters and my fantastic team at @imbmainz. Looking forward to working on our SWItchFate project to unravel the role of BAF chromatin remodelers in neurodevelopment and disease.

Thank you so much for inviting me! What an exciting series of seminars.

Bye, bye US. waiting at the airport for our flight back after another two days of great science discussions and giving a talk MGH/Lurie Center/ Harvard Medical School. It was great to be back in the US after such a long time and to connect with friends and colleagues from there.

Thanks a lot to the organizers for putting together an exciting programme. It was fantastic to present our research on BAF complexes as a speaker in the chromatin remodeling session. Five interesting days with great science and many discussions have just ended. #HNASRC.

Many thanks to the organisers @DormannL and @LemkeLab for putting together such an exciting programme and to all participants for a lively and stimulating meeting. @sfb1551.

Happy to be part of one new and one prolonged SFB. Great thanks to the organizers and everyone involved. Looking forward to 4 exciting years with great science and many collaborations.

Happy to see the first paper of our lab published in #BiochemSocTrans. Julia Varga, Marie Kube, @luck_katja and me wrote a review about the structure, function and synthetic lethalities of the BAF chromatin remodeling complexes.

RT @CeMM_News: In every 5th cancer there's a mutation found in 1 of the #BAFcomplex genes. In their new @NatureGenet paper CeMM PI Stefan K….

Please also see the paper form @SchubelerLab, @marioiurlaro that shows similar and complementary results, and the News and Views published by @HargreavesLab.

This includes @sarahgrosche, Katharina Eva Kohl, Danica Drpic, @jaegemar11, Nara C. Marella, @HanaImrichova, Jung-Ming G. Lin, Gerald Hofstätter, Michael Schuster, @afrendeiro, Anna Koren, Mark Petronczki, @BockLab, André C. Müller, @georg_e_winter and Stefan Kubicek.

The work was a collaborative effort of several people working @CeMM_News and @Boehringer. Many thanks to all co-authors for their contributions!.

Loss of the main ATPase – which is frequently mutated in cancer – results in rapid chromatin changes. Super-enhancers are retained but lose accessibility, H3K27ac and BRD4 binding upon induction of intra-complex synthetic lethalities preventing BAF complex formation or activity.

Implementing the dTAG system, inhibitor and PROTAC treatment in combination with time-resolved genomics methods, our experiments reveal that cells require constant remodeling activity to maintain BAF-controlled sites accessible.

Delighted to share our latest study published in @NatureGenet examining chromatin dynamics after acute perturbation of the BAF chromatin remodelers.

Thank you @NatureGenet! We are excited to see the paper online and to have it published with you.

Isn't this a cool image and technique?.

RT @imbmainz: Last week to apply❗️. We are looking for a Group Leader in Computational Biology🧬in the areas of #genomicinstability, #epigen….

It is a great pleasure to be part of the @sfb1361. I am looking forward to contribute to this important research area.