Yu Sugihara
@YuSugiharaY
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Researcher at The Sainsbury Laboratory; Evolution | Population genetics | Plant-microbe interactions
Norwich, UK
Joined July 2020
🎉 Exciting news during #2025ISMPMI .Our AlphaFold 3 sensor vs helper NLR paper is now published in @NewPhyt!. Big thanks to the reviewers for their constructive feedback 🙏. 📖 Check out the peer-reviewed version here 👇.🔗
nph.onlinelibrary.wiley.com
Click on the article title to read more.
Please check our latest paper on using @GoogleDeepMind AlphaFold 3 to study NLR immune receptors. Here we use AI-guided structural modelling to distinguish between sensor and helper NLRs! 👇🧵 (1/10) #EvoMPMI #NLRbiology #PlantPath #PlantSci.
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RT @InterProDB: InterProScan 6 (beta) is here 🎉.A Nextflow-powered, containerised overhaul for scalable, reproducible protein annotation—de….
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RT @MPPjournal: Population genomics reveals distinct lineage of the Asian soybean rust fungus Phakopsora pachyrhizi in the United States 🇺🇸….
bsppjournals.onlinelibrary.wiley.com
Genomic analysis identifies the US population of Asian soybean rust fungus Phakopsora pachyrhizi as genetically distinct from South American and East African isolates, offering new insights into its...
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RT @HirumaKei: We have posted our latest preprint. We explore how an endophytic fungus promotes plant growth and fitness under fluctuating….
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RT @amiralito_: Thank you @NewPhyt for organizing this great meeting. Met some very cool people and had constructive discussions! I present….
zenodo.org
NLR proteins are intracellular immune receptors present across all kingdoms of life, with exceptional diversification in plants. NLRs can function in diverse configurations, including singletons,...
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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RT @michhulin: Happy to share the first paper from my lab! We wrote a review on bacterial plant pathogen evolution 🧫🌱@michiganstateu @MSU_P….
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RT @AriaxBio: BindCraft isn't just for miniproteins. A new preprint validates 47-67% success rates for BindCraft-derived peptides with nM….
ariax.bio
Learn how to harness BindCraft's newly validated peptide design capabilities. From setup to optimization, master the art of creating high-affinity peptide binders for your therapeutic targets.
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RT @jampei2: New preprint available! We introduced PLANT, an AI predicting the antigenicity of seasonal influenza viruses based on HA seque….
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RT @KamounLab: Great to hear. Huge respect for non-profits like @NewPhyt, which plays a vital role in fostering an inclusive publishing cul….
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RT @mpcontreras4: Thank you @GetGenome for sponsoring this fantastic meeting and fostering connections among global South researchers. In A….
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RT @yoakiyama: Beyond monomeric structures, accurate prediction of protein-protein interactions is crucial for understanding protein functi….
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RT @yoakiyama: Excited to share work with @ZhidianZ, Milot Mirdita, Martin Steinegger, and @sokrypton ..TLDR: We in….
biorxiv.org
Recent efforts in protein language modeling have focused on scaling single-sequence models and their training data, requiring vast compute resources that limit accessibility. Although models that use...
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RT @jsantoyo: A high-quality bread wheat genome unravels adaptive evolution of wheat end-use quality. #WheatGenome #AdaptiveEvolution #Whea….
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RT @NVIDIAHealth: 🚀 The NVIDIA Boltz-2 NIM microservice just got an upgrade: binding‑affinity prediction is now live, at 2-3x speedup over….
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RT @amiralito_: Imagine actively vouching for publishing models from the likes of Elsevier and Springer and talking against preprints in an….
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RT @JerryTianrunLi: I’m happy to share that the research article from my PhD is now finally published online in Nature Plants! This work wa….
nature.com
Nature Plants - Receptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of...
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RT @gravino_matteo: 🎉 Thrilled to share our latest work, now published in @NewPhyt!. 🌱 Aphid effector Mp10 fine-tunes plant immunity via ED….
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RT @biorxiv_plants: CMV can spread through plant to plant contact: implications for experimental practice #biorxiv_….
biorxiv.org
Cucumber mosaic virus (CMV) is a major plant pathogen with a worldwide distribution and the widest host range among all known plant viruses. It affects numerous crop species and can cause symptoms...
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RT @nataliagupa: I am thrilled to share the 2nd chapter of my PhD with @ADSteinbrenner. In collaboration with @TiszaPatrick, we demonstrate….
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RT @ThePlantCell: A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes (Daniel Lüdke….
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