X David Li Lab
@XDavidLiLab1
Followers
672
Following
357
Media
20
Statuses
157
Professor in HKU Department of Chemistry，School of Biological Science and School of Biomedical Science. Epigenetics and Chemical Biology.
Hong Kong
Joined February 2021
Tenure-Track Professoriate Position in Chemical Biology at The University of Hong Kong https://t.co/uaR8EkacWj
nature.com
The University of Hong Kong Tenure-Track Professoriate Position in Chemical Biology (Ref.: 532542) The Department of Chemistry at The University of...
0
0
1
Congrats to Shixian @Linlab_ZJU on this paradigm-shiftimg work. Unnatural amino acid incorporation using rare codons. Really COOL!!
🔊Check out our work in @ScienceMagazine. We identify a new weak point (TCG codon) in the codon table of mammalian cells and recode it into non-canonical amino acids (ncAAs) with impressive efficiency and selectivity. This strategy, rare codon recoding (RCR), is very different!
1
0
4
A new application of photo-ANA to interrogate tissue-specific protein-protein interactions is now published in PNAS. MACSPI enables tissue-selective proteomic and interactomic analyses in multicellular organisms | PNAS https://t.co/I6TxeyD4vY
How long and how much it takes from idea to publication? Here is my tale of three molecules that I designed more than 11 years ago.
2
5
49
I am honored to receive this recognition from HKU, where I studied and have served for more than 12 years😊
Congrats to Prof David Li (@XDavidLiLab1) from @HKU_Chemistry and Prof Stephanie Ma (@stephaniema912) from @hkusbms on being awarded this year's #HKU Outstanding Researcher Award for their exceptional research accomplishments! 🎥 https://t.co/FlAgtzz7f3
3
2
28
A Must-Read thoughtful and comprehensive review from my colleague Xuechen @LiXuechen_HKU, a Master of Chemical Protein Synthesis!!
We put a lot of thinkings and efforts in this paper. Hope this will be useful to the peptide/protein chemistry community. "Precision in Protein Chemical Modification and Total Synthesis".
3
0
10
Reunion of Kapoor lab @KapoorLab_RU alumni @JeffTiLab @XDavidLiLab1 and collaborator @Hippo326 for hotpot in Hong Kong😁
1
3
34
Great to visit @TheCrick institute for the first HKU-Crick symposium together with many colleagues from @hkusbms @hkumed @hku_science. As the only chemist in the symposium, I am glad to learn lots of new frontier biology.
1
0
12
I am very honored to receive 2024 Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry. https://t.co/rO3GTSwolk Thanks to @TetrahedronChem for recognizing our works, and continuous support from @hku_science and @HKU_Chemistry
12
1
70
Chemical approach to deciphering tubulin 'code'. Beautiful work from @Beatfierz lab!
Our work w/ @Aumeier_Lab, @unige_en and many others @EPFL_CHEM_Tweet & @epflSV, out in @NatureChemistry, where we produce tubulins with defined PTMs and demonstrate that polyE primes MTs for detyrosination: https://t.co/7nSvlykTSf; big congrats to 1st authors Eduard and Simon!
0
0
5
Time flies! Last time to the US was the summer 2019. NYC, here I am!
2
0
22
I checked it out. Indeed, the authors (the first and/or the last) are mentioned for every piece of work discussed in this article, except for us. Instead, we are mentioned as "a team of Hong Kong University" or "Hong Kong team"
2
0
11
My students asked me "why only our names are selectively missed when our work is discussed in this article? Is it because that we are doing science in Hong Kong but not in the US?" @metricausa @naturemethods
nature.com
Nature Methods - Chemical modifications to DNA, histones and RNA make changes happen. Scientists are exploring ways to track these modifications and how they interact.
5
5
21
I would like to share with you our new work on the identification of the first bona fide 'reader' of #histone H3K79 methylation, which has been a mystery since the discovery of this modification in 2002. https://t.co/xPfNz2VQTg today online in @ScienceMagazine
science.org
A nucleosome-based photoaffinity probe identified menin as an H3K79me2 reader that binds enhancers to activate transcription.
10
74
340
As I wrote in the Voices of Chemical Biology in response to the question “What advice would you give to a junior scientist interested in pursuing a career in chemical biology?” in 2015, NChemB’s 10th Anniversary.
4
3
64
Although it was a quite long and tough journey from idea to publication for these three molecules (in fact, for most of my projects), I still insist on not stopping at the proof-of-concept studies, but establishing robust and useful methodology to answer real biological questions
1
0
26
This work is finally published today in Nature Chemical Biology ( https://t.co/Jh4PtOw2Tr).
nature.com
Nature Chemical Biology - A bifunctional amino acid, photo-ANA, equipped with a bio-orthogonal handle and a photoreactive warhead, specifically labels Salmonella spp. during infection and enables...
2
2
51
He developed a method for selectively labeling of bacterial proteome using photo-ANA, which enables simultaneous analysis of bacterial proteome reprogramming and pathogen-host protein interactions of Salmonella Typhimurium during infection.
1
0
12
Photo-ANA was also synthesized by Tangpo after he made photo-lysine. So it was synthesized in 2015 and Xiaomeng spent next 7 years to explore and demonstrate its applications to address meaningful biological questions.
1
0
10