Honored, humbled and extremely excited to be part of this fantastic new
#HFA
board 2024-2026
➡️ Together with
@MarcoMetra
we will be inclusive and reunite East, West, North and South !
➡️ Leave no one behind, really no one !
➡️ Grow Together !
Hello, I'm Wilfried Mullens, board member of
#HFA_ESC
and would like to use twitter as an educational platform. I would love to interact with the HF community and share insights to improve the care for
#heartfailure
.
Breaking News
@AHAScience
with
#TRANSFORMHF
- the largest (N=2859) ambulatory
#heartfailure
diuretic trial to determine if torsemide would be superior to furosemide to ⬇️ reduce all-cause mortality - what a huge accomplishment of
@robmentz
et al!!! (1/9)
FIRST INTERVIEW with
@AlexMebazaa
after his
#STRONGHF
LBCT
@AHAScience
which overwhelmingly demonstrated the benefit of protocolized (i.e.mandatory) rapid optimization of GDMT vs usual care post
#heartfailure
hospitalization! (1/9)
Results of the randomized
#ADVOR
trial are soon coming your way! It's the largest diuretic trial in acute
#heartfailure
ever conducted (N=519) and will test acetazolamide on top of loop diuretics. Recruitment is finished and full database lock is anticipated. Find out more (1/9).
What would be your loop diuretic strategy in this patient with acute
#heartfailure
and volume overload ?
🔹decreased eGFR 37 mL/min (normally around 52)
🔹Na 135 K 3.6
🔹80 furosemide od at home
Please explain your choice.
#cardiotwitter
Question 1/3: what initial dose?
Honored, humbled and very excited to be selected as candidate for position of president-elect for the
#HFA
board elections!
To all members, please don’t forget to vote for these fantastic people!
Here are my top six priorities....together we can make it
Baseline characteristics paper of
#ADVOR
published which is largest RCT on diuretic therapy in AHF. Compared with other diuretic RCT: more elderly population, ↑congestion - NT-proBNP > 6000, 82% CKD = patient profile observed in clinical practice (1/4)
Next step towards personalized diuretic therapy???
➡️ results of the
#EASYHF
(Nurse-Led Diuretic Titration via Point of Care Urinary Sodium Sensor) to be presented
#HeartFailure2024
➡️ Late Breaking Clinical Trial Session May 11 - Room 1 - 1.45-2.45 pm by E.Meekers part of
Tweetorial on
#vasodilators
for low-output
#heartfailure
to improve hemodynamics which help to decongest better and allow introduction/uptitration of neurohumorel blockers.
(as addendum to ) (1/10)
What is your take on
#vasodilators
in acute
#HeartFailure
? The upcoming November issue of
#EHJACVC
will bring you a PRO/CON "Vasodilator therapy in acute heart failure revisited"
As our PRO paper was published in advanced access, a sneak preview Tweetorial below...
@EHJACVCEiC
Congestion rules
#ESCcongress
- tips and tricks on how to diagnose acute decompensated
#heartfailure
by Joann Lindefeld and co. Now let’s aggresively treat - “door to combo-diuretic time”
#ADVOR
part of the Top 10 papers in Heart Failure and Cardiomyopathies - "These data likely will shift the standard diuretic regimen in AHF" according to
@rudolf_deboer
@JBauersachsMD
😃
STAY TUNED for answers to 2 important clinical questions in AHF soon to be revelead
@AHAmeeting
in LBCT session of
#ADVOR
!!!
1) Is acetazolamide equally effective in HFpEF and HFrEF
@PieterMartensMD
?
2) Is a natriuresis guided decongestive approach beneficial
@FH_Verbrugge
?
Now is the time to register for the interactive, practical, and challenging HFA Clinical Practice Update Course on
#heartfailure
taking place online on 24+25 November 2022. Don't hesitate, just do it and spread the word!
@HFA_President
@_antocannata
Pragmatic real-life RCTs with easy implementable cheap options to treat
#heartfailure
better by
#HFAYoung
is one fantastic way to move research forward. Kuddos to
@EvelyneMeekers
EASY-HF
📍Improved natriuresis & diuresis without increased adverse events in ADHF patients.
📍Bedside UNa sensor facilitates rapid diuretic adjustments by nurses, preferred over 24h UC.
📍Standardized protocol + UNa sensor allows personalized diuretic titration in first
Why
#kidney
function does not equal
#GFR
(and certainly not Cr), making it an elusive target in clinical practice & the latter a poor surrogate outcome, despite its robust correlation with prognosis. Caring for kidneys versus improving Cr/GFR. A thread below:
Do you want
#HFA
to improve 1) Education, 2) Certification/QCC, 3) Diversity, 4) Scientific Excellence, 5) Advocacy, and 6) Nation Societ in spirit of openness, transparency, interdisciplinary support and mutual respect ?
➡️ ecourage to vote
➡️ my
📢
#ENACTHF
has been accepted as
#LBCT
at
#HeartFailure2023
!
📌Acute
#hearfailure
pts with volume overload
📌
#ESC
guidelines diuretic protocol vs. standard of care
📌29 centers around the 🌍.
📁Study design:
👉Join us on 22 May, 11:15-12:15 in Room 1.
Join me and more than 5OOO
#heartfailure
caregivers in the largest congress of the world packed with top-notch science and a lot of interactive sessions....
💥My top 10 learning points from the
#ESCCongress
2022💥
A thread for cardiologists/general physicians
1) Addition of IV acetazolamide to IV furosemide in AHF results in 46% higher incidence of successful decongestion after 3 days
EVIDENCE: ADVOR
The first dose of the loop diuretic should be 40 mg furosemide (=1 mg bumetanide) in diuretic naïve and twice the home dose in patients on loop diuretic (3/9).
Excited to be part of
#HeartFailure2022
also as twitter ambassador. Join us at the largest HF congress wordwide and stay tuned for live updates during the meeting.
Both diuretic
#heartfailure
trials are of additive value but
#advor
strongly supports use of
#acetazolamide
on top of loop diuretic in all EF ranges. 'Door to combo-diuretic' time but based upon scientific data available probably Acetazolamide first.
Diuretics work for 6-8 hours so evaluate the effect within hours after administration. The next dose should be individualized according to the natriuretic and/or diuretic response which should be Na > 50-70 meq/l and/or volume > 100-150 ml/hour (4/9).
Do you think that
#ADVOR
will be the first trial ever in a long history of neutral
#ADHF
trials that will finally reach a clinically very relevant positive end point?
So Happy and Lucky to be surrounded by these HF-congestion game changers!! Thanks for your amazing work (and for the ADVOR meeting). PS: Retirement no allowed 😉
@yulnunezvill
@WilfriedMullens