William A Donald
@WAlexSyd
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Professor and ARC Future Fellow, School of Chemistry @unsw
Sydney, New South Wales
Joined February 2009
Silicosis is preventable but difficult to detect early. A promising new breath test could change this. @WAlexSyd @UNSW
theconversation.com
Silicosis is preventable but difficult to detect early. A promising new breath test could change this.
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šAnnouncing our ANZSMS 2025 Medalists š Congratulations to Prof Nicki Packer from @Macquarie_Uni and A/Prof Shane Ellis (@EllisMSILab) from @UOW ! Join us at AUS-omics this year from May 18 - 21 to celebrate this wonderful achievement! š
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Here is the promised update! Now the EPA has released their statement we can reveal all the disgusting details of the ātar ballsā.... ...which are actually human-generated waste of fat and grease! Hereās what @UNSWScience and MWAC foundā¦ thread below! š§µ
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At @UNSWScience we have been investigating the tar balls that washed up on Coogee and other Sydney beaches. What do we know (and not know!) so far? Here comes our thread!
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Very excited to host next weekās #DFCI #TPD webinar with two fantastic speakers! Amanda Ng from @georg_e_winter's lab @CeMM_News and @WAlexSyd @UNSW will talk about new methods to search for and study molecular glues. Join us on Thursday, Feb 8th at 11 am! https://t.co/p49hHhINON
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Think you can wrangle us? https://t.co/nguP6dNFwg
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Great effort by TRIANA scientists with @UNSW to explore novel technologies to discover and characterize molecular glues!
pubs.acs.org
Molecular glues stabilize interactions between E3 ligases and novel substrates to promote substrate degradation, thereby facilitating the inhibition of traditionally āundruggableā protein targets....
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Native MS can also provide quantitative descriptions of molecular glue efficacy and enable the binding specificity of E3 ligases to be determined in a single measurement.
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Out now at @J_A_C_S , we we demonstrate that native mass spectrometry and mass photometry can reveal unique mechanistic insights into the action of molecular glues, including the effects of such small molecules on the oligomeric organization of E3 ligases.
pubs.acs.org
Molecular glues stabilize interactions between E3 ligases and novel substrates to promote substrate degradation, thereby facilitating the inhibition of traditionally āundruggableā protein targets....
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Amazing study with enormous health implications co-lead by #UNSWScientia Alex Donald @WAlexSyd! Congrats Alex! šš @dane_mcc How smelly T-shirts and AI helped unlock secret to detecting Parkinsonās disease
smh.com.au
An AI program developed by researchers in Sydney and Boston could help predict the disease up to 15 years before symptoms appear.
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For those interested, here is our paper with @vkola_lab on CRANK-MS out now at @ACSCentSci:
pubs.acs.org
The use of machine learning (ML) with metabolomics provides opportunities for the early diagnosis of disease. However, the accuracy of ML and extent of information obtained from metabolomics can be...
5. Using AI to detect early Parkinson's Scientists from UNSW Sydney and Boston University have developed CRANK-MS, which could detect Parkinson's disease before the onset of symptoms.
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Our people are amazing. Check out this piece by @WAlexSyd and student Diana Zhang about early detection of Parkinsonās. @unswscience @unsw
theconversation.com
This AI tool showed promise for early diagnosis. It also pointed to chemicals that may reduce or increase the risk of Parkinsonās.
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Hearty congratulations to @ARCwinecentre @CharlesSturtUni PhD student Liang for her recent publication in FoodChem. Another excellent collaboration @UNSWScience @WAlexSyd Detection and prediction of Botrytis cinerea infection levels in wine ...
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At #AACR2023 with the amazing ā¦@CarolynBertozziā©!! The timing worked out perfectly because our paper (preprint link: https://t.co/io6octf2e1) got accepted just 2 days ago ā¦@ACSCentSciā©!! ā¦@BUMedicineā© ā¦@BU_CDSā© ā¦@BUCompSciā© ā¦@UNSWā© #Parkinsons
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Nice day and spot for our lab's end of year celebration with a great group of people, trivia, secret santa, bon bons, and a picnic with different types of food from all over the world!
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We have new postdoc opening in the lab to study the effects of small molecules on protein-protein interactions using native mass spectrometry, ion mobility and high throughput sample prep methods. https://t.co/rQ2upxYmY1
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Highly charged and unfolded proteins formed from native solutions in low-to-sub microseconds by theta nanoESI & fusion of charged droplets from two separate Taylor cones. Nice to see @susannahbrown36's work on this out now @an_chem. https://t.co/MAVpjfhVyQ
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Open #postdoc position in our group! Join us in Sydney @UNSW. Project involves protein #massspectrometry & is funded by the ARC. Position information and details on how to apply in the link. Closes 29 August. #sciencejobs @PostdocO #postdocjobs @anzsms
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