Fingers crossed that analysis will be complete in time for ECCMID late-breakers! 6 countries recruited patients. Shout out to investigators involved in this clinician-initiated trial, like @padstamundo @davidantibiotic @davidlye70 @shirinklmddn

The Game Changer Trial (cefiderocol versus standard of care for hospital-acquired bloodstream infection) is fully recruited (>500 patients). We are now eagerly awaiting the results. The hypothesis is non-inferiority but superiority will be examined if non-inferiority is achieved.

In this double-blind, randomized trial, vancomycin was added to cefazolin as surgical prophylaxis for arthroplasty. Surgical-site infections occurred in 4.5% of vancomycin recipients and 3.5% of placebo recipients. Full results of the ASAP trial:

@ABStewardess @burcucella Yes and the testing can be technically challenging which also feeds uncertainty .. hopefully @UQ_GAMECHANGER RCT will help resolve some questions about clinical efficacy in bacteraemia and MDR-GNBs - will complete recruitment soon!

500th participant enrolled! A huge achievement for this trial with so much gratitude for all our collaborators on getting us to this mark. LPI October 31st so watch this space for results coming the first half of 2024! @davidantibiotic @padstamundo @UQMedicine #MERINOgroup

Our 400th participant has been reached today! Great work Dr. Darunee Chotiprasitsakul and team @ Ramathibodi Hospital. Thank you all for keeping the momentum going on this trial’s final stretch! @davidantibiotic @padstamundo #MERINOnetwork @UQMedicine

International platform trials: as diseases cross borders, so should trials

ChatGPT and antimicrobial advice: the end of the consulting infection doctor?

FDA provides rationale for not accepting Polymyxin Breakpoints for Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp. https://t.co/S7vcYALFOq via @ein_news

Interesting RCT - Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial

Great to see such a pragmatic, impactful trial! Routine sterile glove and instrument change at the time of abdominal wound closure to prevent surgical site infection (ChEETAh): a pragmatic, cluster-randomised trial in seven LMICs

After discussing progress of SNAP at #IDWeek2022 another milestone for SNAP! This time the enrolment was at the Royal Brisbane and Women's Hospital, team led by @Bridb3. @syctong @Josh_S_Davis

A brilliant milestone reached with the team at Taichung Veterans General Hospital in Taiwan recruiting #300 onto the trial! Thank you again to all our hardworking collaborators involved. @davidantibiotic @padstamundo #MERINOnetwork #UQCCR

A great way to finish a day with 3 enrolments within 1 hour! We are so lucky to work with amazing collaborators on this trial. @davidantibiotic @MERINOnetwork @UQCCR

Another milestone for the GC Trial reached with our 250th participant enrolled today! Excellent work by Dr. Helmi Sulaiman @edenhelmi and team @ UMMC, Malaysia for their consistently stellar support! #UQCCR #MERINOnetwork @davidantibiotic

Great visual from Dr. Richard Alm’s @CARB_X visit to #UQCCR highlighting the backbone antimicrobials play in sustaining modern medicine @UQMedicine #MERINOnetwork

Achromobacter Species: An Emerging Cause of Community-Onset Bloodstream Infections https://t.co/NHlInASNSd #mdpimicroorganisms via @Micro_MDPI

https://t.co/PLt5AeFBLw Lenzilumab plus remdesivir not superior to placebo plus remdesivir for COVID-19

https://t.co/Sjl4JPtJ3p Exebacase trial as adjunctive therapy for MRSA stopped early because of futility

There's a reason that trials are called just that. Two disappointing results recently released: