Gould Lab UCSF
@UCSFGouldLab
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Gould Lab studies roles of #BasementMembrane and #ECMatrix, and finds cures of a multi-system disorder #GouldSyndrome caused by mutations in #collagenIV.
UCSF, San Francisco, CA
Joined April 2020
Today April 12th is #GouldSyndromeAwareness Day because this disease is caused by mutations in the Col4⃣ a1⃣ and a2⃣ genes. Please find your time to watch this 4 min video 👇👇👇 https://t.co/wmJuQb1arO via @YouTube
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Thank you for advertising our new preprint, Yutaka! 📢 If you are interested in prolyl 4-hydroxylation and collagen biosynthesis, you can learn how these go in Drosoplia ‼️🪰🪰🪰 Happy Friday 😎
Our preprint is out! Great collaboration with @yoshihiro0604, @mel_toups, Marwan Elkrewi, Allison Zajac, and @SHBLab Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV (13 posts follow) ↓ https://t.co/Ewkos04AOO
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Please add your reading list! Our shiny collagen IV paper is out now😎 Enjoy beautiful red and green images! Yes, I MUST do molecular characterization of this "beauty" collagen IV... My TO-DO list is too much😅 @UCSFGouldLab
Mao et al introduce a novel tagged Col4a1 mouse model for studying basement membrane dynamics, which provides important details of COL4A1 turnover in cerebral vasculature & shows that Col4a1 heterozygous deletion is better tolerated than missense mutations https://t.co/ODc9TgDty3
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My first post of 2025 is here! 😎 Excited to share my new paper on horse collagen I 🐎. We explored COL1 structure and modifications in horses with LH1 mutations. Don’t miss the unique images of twisted collagen fibrils—check it out below!👇👇👇
Biochemical characterization of collagen I in Warmblood Fragile Foal Syndrome horse lysyl hydroxylase 1 mutation. #micropublication #biology #data #caltechlibrary # quus caballus #Biochemistry #NewFinding
https://t.co/LlRwCANfdl
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Interesting collaboration coming from the @UCSFGouldLab and @TamaraAlliston lab to identify an unexpected role of #collagen type IV in bone biology in connection with #TGFβ https://t.co/q0dzEwK7We
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Want to learn about #GouldSyndrome? Check out this month's featured #CCMBM #MSK member publication from @UCSFGouldLab & @TamaraAlliston: "Skeletal pathology in mouse models of Gould syndrome is partially alleviated by genetically reducing TGFβ signaling." https://t.co/Pmj4Y83lfj
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Douglas Gould @UCSFGouldLab et al. investigate whether TGFβ Signaling Dysregulation May Contribute to COL4A1-Related Glaucomatous Optic Nerve Damage, https://t.co/qmWt2AHr8t.
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We are please to announce Drs. Yoshi Ishikawa @yoshihiro0604 and Masashi Yanagisawa as the Luncheon Seminar speakers at #JSMBM24. 日本結合組織学会大会のランチョンセミナーはUCSF のYoshi Ishikawa 先生によるコラーゲンのフォールディング、Masashi Yanagisawa 先生による睡眠の講演です！
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What an incredible first day at the #Alportworkshop on #WorldKidneyDay - so much has happened in the last 10 years & always so good to catch up with #basementmembrane friends ❤️@JeffMinerPhD @UCSFGouldLab @SherwoodElegans @stramerlab
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Exciting news! Our new research paper is published! This exciting study was done with a amazing collaborator Scott Early (@vesselman) lab. Congratulations🎉🍻🥳
In a model of #GouldSyndrome, researchers connect brain lesions and hemorrhages to disruptions in #CalciumSignaling in smooth muscle cells from misfolded collagen, impairing vessel’s ability to regulate cerebral blood flow. @UCSFGouldLab @CobreUnr
https://t.co/17slEtfvoF
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#GouldSyndrome had great chemistry with #AlportSyndrome and basement membrane researchers at #ASMB2023! It is important to know each other, exchange ideas, and discuss future collaborations in person. I and @yoshihiro0604 are happy to be in this picture! Join Collagen IV biology!
Charismatic #AlportSyndrome and basement membrane researchers at #ASMB2023 @amsocmatbio enjoying some "networking time" together after a full day of scientific sessions in SLC. Thanks to @AlportSyndFndn for generously supporting the conference! @RLWczyk @BoudkoSergei @RW_Naylor
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Looking for another exciting #ECMatrix conference before our biennial meeting? Check out the #Collagen #GordonConference, where our very own ASMB council member Doug Gould @UCSFGouldLab is vice-chair! 👇 https://t.co/AGW1QFYTvR
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We appreciate that someone like our study and share it with Twitter community! Thank you!
#NAVBO Member Publication Alert Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in #GouldSyndrome Dr. Scott Earley group @PNASNews 2023 @UCSFGouldLab @vesselman
https://t.co/vwODQu8HDs
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Beautiful work Earley lab! What a great collaboration!
Our latest preprint provides proof of concept for the use of PI3K inhibitors to treat vascular dementia. @UCSFGouldLab @unrmed @DoctorMC_ PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease
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Please check this latest publication we involved about Gould syndrome! Great work and excellent collaboration! Cheers! 👍🎉
Faulty TRPM4 channels underlie age-dependent cerebral vascular dysfunction in Gould syndrome | Proceedings of the National Academy of Sciences https://t.co/UA7dFEyLjb Check out out latest paper, part of an amazing collaboration with @UCSFGouldLab !
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Check our new paper!! Thank you @Xiaowei71 😊
check out recent work from @UCSFGouldLab on how Col4 is involved in vascular function through TGFb pathway. New insights for vascular pathologies including CSVD and @GouldSyndrome AddThis | Home
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Congratulations to Danielle @RyansMom2, Sheena, and everyone with @GouldSyndrome
I am so proud to share the very first manuscript out of the @GouldSyndrome Global Registry! @SheelMd @UCSFGouldLab @LisaMarieShank
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Finally, we could do a lab outing after the pandemic! Beautiful weather, excellent lab members and great foods/drinks made us happy! ☀️🍱🥂😎😁
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Our collaborator wants young energies!! We look forward to working together 💪🔬🧫
We are hiring two new postdocs! Come to Reno and help us develop new animal models of cerebral small vessel diseases (cSVDs) and vascular cognitive impairment and dementia (VCID). This is part of a great collaboration with @UCSFGouldLab and @DoctorMC_.
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Happy National Postdoc Appreciation week to from the Gould lab to Kayla, Andrea, Xiaowei(@Xiaowei71), all former Gould lab postdocs and the rest of you hard working postdocs out there! 🔬🧪✍️💪🦾🙌 @UCSF Postdocs #NPAW2021 #ucsfNPAW
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