Tyler Heiss
@TylerKHeiss1
Followers
205
Following
243
Media
4
Statuses
41
Improving life for all through science | F32 NRSA (NCI) Postdoc Fellow w/ @KapoorLab_RU | Ph.D. w/ @jenn_prescher | B.S. w/ @CLGrimesLab
Manhattan, NY
Joined February 2021
I'm thrilled to share that I've been awarded an NIH NRSA F32 fellowship through the NCI to support my postdoctoral studies at Rockefeller! Beyond thankful, and looking forward to tackling unsolved problems at the interface of chemical and cancer biology over the next three years
3
2
33
RT @jaredrams: Super excited to see my most recent work (and first paper!) from the @KapoorLab_RU online @J_A_C_S! By taking advantage of e….
pubs.acs.org
Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA substrates. These enzymes have key roles in diverse cellular...
0
6
0
RT @KapoorLab_RU: Our latest review, written by graduate student Natalie Jones, is online! Click below to learn how genetic approaches can….
0
10
0
RT @katenokv: We have an open position for a Postdoctoral researcher in Chemical Biology with Synthetic Chemistry experience! If you are in….
jobrxiv.org
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
0
38
0
RT @J_A_C_S: Red-Shifted Coumarin Luciferins for Improved Bioluminescence Imaging @UCIrvine @UCIChemistry @theNCI @ASUBiodesign @ASU_SMS #R….
pubs.acs.org
Multicomponent bioluminescence imaging in vivo requires an expanded collection of tissue-penetrant probes. Toward this end, we generated a new class of near-infrared (NIR) emitting coumarin luciferin...
0
8
0
RT @XiaoyuShi2: I am thrilled to receive the NIH Director's New Innovator Award for a conceptually novel method called GO3D single-cell spa….
0
14
0
RT @KJMbio: Excited to share that I will be joining the Department of Biochemistry and Molecular Biology in the Rutgers Robert Wood Johnson….
0
19
0
RT @KJMbio: @eLife .Please check out our paper on the AAA ATPase Mdn1!. Mdn1 drives ribosome biogenesis by extracti….
elifesciences.org
The MIDAS domain of Mdn1, an ATP-driven mechanoenzyme involved in ribosome biogenesis, forms catch bonds with two different ubiquitin-like domain-containing ribosomal assembly factors.
0
7
0
Because of the high fluorescent enhancement, biocompatibility, and multicomponent imaging capabilities, we anticipate that fluorogenic cyclopropenones should enable a broad range of biological pursuits. Congrats and many thanks to my advisor at @UCIChemistry, @jenn_prescher!.
1
0
2
We next showcased this reaction's utility to image biological events as both a standalone method and alongside other fluorogenic chemistries. Excitingly, dual orthogonal reactions successfully imaged two metabolites simultaneously in live cells, a first for the field.
1
0
0
We converted "dim" cyclopropenone reporters into coumarin products via a regioselective activation and cyclization strategy. Fluorescent enhancement was among the brightest fluorogenic reactions to date (~1600x)!.
1
0
1
Thrilled to see this story finally out today in @J_A_C_S. Here, we pioneer a first-in class fluorescence "turn-on" reaction of cyclopropenones and phosphines for multicomponent, real-time imaging in live mammalian cells. (1/4) .
3
40
285
Super excited to share that I'll start as a postdoctoral researcher in Manhattan next week with Tarun Kapoor's lab at @RockefellerUniv. Looking forward to digging in to structure-based drug design & structural/cancer biology with this fantastic team!
2
0
31
RT @AChemSynBio: Thrilled to share this preprint, Virus-Assisted Directed Evolution of tRNAs (VADER) in mammalian cells. A story seven year….
biorxiv.org
Site-specific incorporation of unnatural amino acids (Uaas) in living cells relies on engineered aminoacyl-tRNA synthetase/tRNA pairs borrowed from a distant domain of life. Such heterologous...
0
49
0
RT @FoxGroupUD: Congratulations to the awesome Dr. Jessica Pigga- our most recent Ph.D.- whose method for improving TCO synthesis and prope….
0
2
0
RT @AlbertBourla: Grateful to the @US_FDA for authorizing emergency use of Pfizer's oral antiviral to treat mild to moderate #COVID19 in ce….
0
62
0
Beyond THRILLED to announce that I successfully defended my Ph. D. thesis! Many, many thanks to my advisor @jenn_prescher and all those in the Prescher lab for their support over the last five years. On to the next adventure!
2
2
60
RT @cziscience: 👋🏼 Meet @ChanZuckerberg Visual Proteomics Imaging grantees Jennifer Prescher + Xiaoyu Shi of @UCIrvine. They’re developing….
0
11
0
RT @katecarroll_lab: Old chemistry, new tricks @NatureChemistry ! Repurposing Wittig reagents for redox biology. See our collaborative work….
0
16
0