Thilo J. Zander
@ThiloZander
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MD. Medical Oncologist. Focused on innovative Lymphoma & Myeloma care. Opinions solely personal views.
Luzern, Schweiz
Joined April 2015
#ASH25: Presented by @BeaRazzo @AlGarfall as poster but IMO as imp as any oral abstract #LimiTEC with Tec cessation after 6-9m for RRMM pts in VGPR+ led to 12m PFS ~65% ➡️n=50, 4 pLOT, 90% TCR, 20% w prior BCMA (ide-cel + BlenRep, 50% with no response to BCMA-DT!!) ➡️60% in CR
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Donor 7069 carried TP53 mutation (Li-Fraumeni syndrome) - One donor, 67 clinics, 14 countries, at least 197 children Terrible. Unbelievable. https://t.co/TMMkMGb1sR
investigations.news-exchange.ebu.ch
The 'Kjeld' case reveals a massive failure in Europe's fertility industry. Learn how one donor bypassed limits and spread a deadly cancer risk across borders.
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Plasma fractionation companies entering a golden decade. Expanding indications are driving unprecedented demand. $GRIFOLS $CSL $ADMA $HAE The picks & shovels of the CART & bispecific antibody boom. This deserves @JacobPlieth @bradloncar deep dives.
One of the most critical aspects of modern care for myeloma patients is providing adequate IgG replacement, particularly for those treated with bispecific antibodies and CAR-Ts. My thoughts and recommendations are below. https://t.co/6MO63sNsLt
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Current H3N2 flu wave now dominant in Europe. Key facts: 🚨Vaccine effectiveness protects vs. severe disease ✅Antivirals (oseltamivir, baloxavir) remain effective 💉Vaccination + early treatment for high-risk groups important. Stay safe everyone!
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CML, Hodgkin and now Myeloma with similar, almost rectangular KM-curves. I love it.
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Metamizol (Novalgin) prophylaxis retrospective comparison: 0% CRS grade ≥2 vs 36% with acetaminophen. ZERO tocilizumab needed vs 44%. Interesting signal from small Brazilian study (n=14) with bispecifics. #ash25 @EricaLammerhirt
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Impressive. New standard of care. Without a doubt.
Epcoritamab + R2 shows major breakthrough in relapsed/refractory follicular lymphoma! ✅ 95.7% response rate (p<0.0001) ✅ 79% reduction in progression risk (HR 0.21, p<0.0001) This triple combo significantly outperformed standard R2 treatment
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Ondansetron is not enough.
“It is presented annually on behalf of the billions of football loving people from around the world to distinguish an individual who exemplifies an unwavering commitment to balancing peace and unity throughout the world through their notable leadership and action. And therefore,
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Fantastic. One remark: We also protect the lives of our boys. Many other cancers are associated with HPV: penis, anus, ENT. Vaccines work.
Australia just recorded zero cervical cancer cases in women under 25 - for the first time since records began in 1982. This is what happens when a country commits to HPV vaccination and screening. We protect our girls and save lives.
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This will be something we remember. #ASH25 First in vivo CART data. Crazy stuff. Congrats, @KeloniaTx
Next month at #ASH25, we will present first-in-human data of KLN-1010, our novel in vivo CAR-T therapy, from our ongoing Ph 1 inMMyCAR study in a late-breaking oral session. https://t.co/73jxrwsErf
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With almost 1,000 myeloma-related communications at this @ASH_hematology #ASH25, it is now impossible to come up with a “Top 10 abstracts” list. Here are 10 topics I found interesting and speak to the continued progress in the #mmsm field on bright display this year
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60 yo woman with germline BRCA1 mutation, 2 prior breast cancers in remission after chemotherapy, now diagnosed high-risk MM. Excellent response to quad-induction. Would u recommend HD-Mel ASCT upfront ? Share your thoughts 🙏👇 @VincentRK @HadidiSamer @Papa_Heme
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🧠DEMENTIA PREVENTION—Almost everyone needs to go out now and get the shingles vaccine ASAP. Don’t wait until age 50 for standard eligibility—ask your doctor for singles vax. MULTIPLE large studies worldwide now show that shingles vaccine strongly prevents dementia onset. Do it.
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