
Graham Collins
@graham74GC
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Associate Professor of Haematology and lymphoma specialist at Oxford Cancer and Haematology centre. Christian, husband and father.
Opinions are mine
Joined December 2013
What a fascinating thread!.
1/.Why is Ki-67 called Ki-67? And why am I attaching a photo of this beautiful city to the tweet? .If you work in pathology or oncology, you’ve likely come across Ki-67 many times. But where does the name come from?. A short 🧵 on the origins, function, and significance of Ki-67.
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Experts such as @ProfChrisPFox @CwynKate @Jessica_Okosun @wendster @pammckay123 and many, many more!.
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It’s back and it’s online. The fantastic #lymphomaManagement course. With much thanks to @LymphomaAction for their support as always. Do sign up to learn about state of the art management of this fascinating disease from international experts. #lymsm.
#LymphomaManagement is back! We’re proud to deliver our leading course for healthcare professionals virtually in 2025, in collaboration with the Oxford Centre for #Haematology (@OxfordHaem). Book today 👉 [1/3]. #LymSM #Lymphoma @tobyeyre82 @graham74GC
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RT @tobyeyre82: Zanubrutinib approved for relapsed #MCL by @NICEComms #lymsm .Final draft guidance avaliable.https:….
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Really hope bispecifics will become available for relapsed mantle.
ICML25: Outpatient fixed duration Mosun-Pola regimen is highly efficacious in 3L+ R/R MCL in this phase 2 cohort: 71% had 3+ high risk features (prior CAR, ASCT, TP53, Blastoid/pleomorphic, Ki67 30%+ etc). ORR 88%, CR79% .CRS all low grade and resolved.
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Reinforces that getting patient to ASCT is important. In my view this trumps CAR-T (if chemosensitive of course).
🧠7y MARIETTA update in SCNSL.PFS 33% in pts <70 (MATRIX/RICE ± ASCT).Best PFS in tx-naïve (52%), isolated CNS relapse (33%), synchronous (11%).Resp after 2cy → better outcomes.Auto-SCT → PFS (64%).IT chemo → better PFS (p=0.017).Trend: single CNS site = better PFS.#ICML2025
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Great work by @ABarrettHaem. NHSE data, older #Hodgkin pts. Outcomes ⬆️ with dox. Clearly may reflect selection, but interesting assocn seen between regional difference in dox use and outcome. Take home message: if safe to use dox then do use it! . #18ICML #ICML25 #lymsm
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