Daniel Auclair
@AuclairDan
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Working hard to bring novel therapies & drug combinations to blood cancer patient.Tweets are my own #precisionmedicine #mmsm #leusm #lymsm
Connecticut
Joined January 2017
RT @calliecoombsmd: Happy to share the long awaited manuscript on Pirtobrutinib in R/R Follicular Lymphoma - ORR 50% with mPFS of 5.8 month….
ashpublications.org
Key Points. Pirtobrutinib demonstrates efficacy in relapsed/refractory follicular lymphoma with an ORR of 52.1% and median DOR of 10.2 monthsPirtobrutinib
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RT @RahulBanerjeeMD: Excellent & important #MMsm work by @nishi_shah_ @JanakiramMurali et al!. Validating @iStopMM 🇮🇸 SMM prediction in the….
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Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics
science.org
Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA...
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RT @BloodPortfolio: Beat AML genetic risk stratification model in a cohort of older VEN/HMA-treated patients with AML .
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RT @Carmen_gondc: 🚨New paper alert🚨. Just published in Blood! . Introducing BloodFlow: a new ultrasensitive method for detecting circulatin….
ashpublications.org
Key PointsBloodFlow detects PRD below the 10–6 threshold, which is associated with independent prognostic value for PFS.The presence of circulating tumor p
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RT @MyelomaAmarc: ZEPFHR-MM (Tec/Tal) is now recruiting at our first site in Queensland @pahospital. This study is a world-first multicentr….
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Really cool work. “Our finding opens the possibility for indirect ubiquitination of a target through a ubiquitinated bifunctional small molecule and more broadly raises the potential for posttranslational modification in trans”
nature.com
Nature Chemical Biology - Li et al. discovered that the cytotoxic synthetic small molecule BRD1732 is directly ubiquitinated in cells. Ubiquitination of BRD1732 is E3 ligase dependent and leads to...
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RT @YaleCancer: New @jclinicalinvest study identifies TET3-overexpressing macrophages as a common driver of chronic inflammation in #MASH,….
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RT @FrancescoMaura4: Excited to share our new paper, out today on @NatureGenet where we use 421 #WGS to reconstruct the evolutionary histo….
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RT @RahulBanerjeeMD: 1/ New @BloodAdvances treasure trove of 🇩🇪 🇺🇸 data about bridging before CAR-T in #MMsm. Bigger is not better when i….
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RT @BCD_AACR: Online First: Impact of Genetic Ancestry on Genomics and Survival Outcomes in T-cell Acute Lymphoblastic Leukemia https://t.c….
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Intriguing approach of administering exogenous CD19 antigen using engineered autologous T cells to extend #CART cell persistence, warrants further research #leusm #lymsm
ashpublications.org
Key PointsA phase 2 academic clinical trial of CD19 CAR T cells demonstrates durable remissions with a 1-year LFS in low disease burden groups of >90%.E
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RT @BloodPortfolio: Rest, then rejuvenate: CD19 boost to improve CAR persistence #clinicaltrialsandobservations.
ashpublications.org
In this issue of Blood, Annesley et al demonstrate durable leukemia-free remissions after SCRI-CAR19 (autologous CD19.4-1BB chimeric antigen receptor T cel
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RT @RahulBanerjeeMD: Predicting #MMsm decades before it happens - fascinating @BloodAdvances work by 🇬🇧 team. Not by looking for MGIP / in….
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Just out: Current Treatment Algorithm — completely open access — for elderly patients with acute myeloid leukemia. AML. @BloodCancerJnl . By @n_gangat @MayoClinic &.Dr. Courtney Dinardo @MDAndersonNews .Link:
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Intriguing data from this invaluable resource that is the UK Biobank. #mmsm.
Dysregulated immune proteins in plasma in the UK Biobank predict multiple myeloma 12 years before clinical diagnosis #lymphoidneoplasia
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RT @MiriamMerad: Excited to share our review highlighting how loss/dysregulation of resident tissue macrophages drives tissue damage in agi….
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Unravelling relatlimab-specific LAG3 biology using biomarker analyses in patients with advanced melanoma in RELATIVITY-047
pubmed.ncbi.nlm.nih.gov
These results highlight the unique biological effects of RELA in combination with NIVO and provide further understanding of the patient characteristics associated with increased benefit from NIVO +...
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