Theodora
@TheodoraGrosu
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PhD student @ucddublin | Epigenetic mechanisms governing pediatric leukemias | @sysbioire @Researchirel
Dublin City, Ireland
Joined February 2020
First-born twins have a higher risk of acute leukemia, but concordance between twins is rare, says a new California twin cohort study. Epigenetics may explain birth order differences. https://t.co/MdzquMRnaH
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Interesting: ChIP-Seq is biased in favor of gene promoters and against intergenic Regions. CUT&Tag identifies H3K9me3 at young repetitive elements undetectable by ChIP-Seq. https://t.co/04UB7z1NSM
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Rapid epigenomic classification of acute leukemia | Nature Genetics
nature.com
Nature Genetics - The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
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Epigenetics Update - A subset of transposable elements as mechano-response enhancer elements in controlling human embryonic stem cell fate https://t.co/q7KLWJta5j
#Epigenetics #StemCells --- High-res insights without cell sorting; https://t.co/WmSYDGXnzb
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OmniPath ( https://t.co/g2JRIODn2k): integrated knowledgebase for multi-omics analysis https://t.co/SYaCvU76su 🧬🖥️🧪 Python module https://t.co/n7As1pmtmv R package https://t.co/bwzjAmuab8
#Rstats
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Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @Nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7, link below)
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This article suggests that TF binding is determined by the sum of multiple, overlapping binding sites. Thus, competition between paralogous TFs for shared high-affinity binding sites may be influences by flanking nucleotides from overlapping, lower-affinity binding sites. 🧵
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Pleased that the 2nd part of my PhD in now available as a preprint! Here, we investigated the epigenomic and transcriptomic changes occurring upon PRC2 depletion in AML cells. https://t.co/xc0v6DUXW3. A thread🧵1/17
biorxiv.org
Background Polycomb Repressive Complex 2 (PRC2) modulates chromatin accessibility and architecture to direct tissue-specific gene expression. PRC2 function is frequently altered in cancer by loss-o...
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Bond group out in force @News_IACR Congrats to Luke @iamnotaprawn for his poster 🏵️ and Theodora @TheodoraGrosu for selection for the Fitzpatrick medal competition @sysbioire @IrishCancerSoc @Researchirel @PrecisionOncIre
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🧶Crafting Team! This group made dozens of gift items by hand, some of which were sold at the bake sale, others shared among family and friends. Including @Koopgirl @TheodoraGrosu and others!
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Excited to announce that @NiTriona will be one of our keynote speakers at the next Ireland Haematology Forum 2024 held at @ucddublin You can register on the QR code below #AIHF2024 #earlycareer #UCD
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Bond group out in force at @News_IACR @EACRnews @AACR conference in Dublin today @sysbioire @PrecisionOncIre @DevelopMed_MSCA @IrishCancerSoc
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Huge congratulations to our own @iamnotaprawn !!! He has promised to wear his medal to the lab all next week @sysbioire
Our Senior Researcher of the Year Award winner is Dr Luke Jones! Massive thanks to all our nominees, for their excellent presentations and incredible contribution they make to cancer research. #CancerResearch #ResearchAwards2024
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Glad to see my PhD work out as a pre-print where we show that PRC2 depletion in T-ALL causes Asparaginase resistance by reducing of WNT-STOP signalling activity. https://t.co/84acwzTGgX A thread👇👇
biorxiv.org
Loss-of-function mutations and deletions in core components of the epigenetic Polycomb Repressive Complex 2 (PRC2) are associated with poor prognosis and treatment resistance in T-acute lymphoblastic...
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New data from us! A proposed mechanism for asparaginase resistance in T-ALL with altered PRC2. Led by @LefeivreT during his @NCRCIre @CMRF_Crumlin funded PhD project, co-supervised by @colmr. More acknowledgements 👇
biorxiv.org
Loss-of-function mutations and deletions in core components of the epigenetic Polycomb Repressive Complex 2 (PRC2) are associated with poor prognosis and treatment resistance in T-acute lymphoblastic...
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The @jbond2019 Group is well represented today at our #UCDFestival booth! Thanks to all of our PhD students, postdocs & SBI staff (Susan Yeates!) for your great work planning the activities! Also a big shout out to Theodora Grosu for the fabulous animated video she created!😍
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We had such a great day yesterday for our #YPAG Meeting @sysbioire. We heard from 12 researchers about their work, contributed our ideas to some upcoming projects and got to see for ourselves what happens in the lab!
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We’re finishing Sept on a high note with a celebration of recent achievements! Well done to all, but especially our Green Lab team, everyone in @PrecisionOncIre & the authors of our #cSTAR paper in Nature. Give yourselves a round of applause! 👏👏👏 #researchculture #teamwork
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We asked our researchers - Why are #digitaltwins important for the future of paediatric oncology? Check out the video below for their answers. @UCD_Research @UCDMedicine @CHIatCrumlin @PrecisionOncIre #ChildhoodCancerAwarenessMonth #PrecisionMedicine
https://t.co/0Eo65EaNQF
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WE ARE HIRING!!! Minimum two year junior or senior post-doc position working on @scienceirel funded childhood leukaemia epigenetics @sysbioire @UCDMedicine @CHIatCrumlin. Details here https://t.co/vnsIAn0kd2 DMs open!
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