Oliver Rackham
@TheRackhamLab
Followers
1K
Following
2K
Media
48
Statuses
115
Synthetic biologist engineering mitochondria, RNA and new gene editing systems. NHMRC Investigator and Professor @CurtinUni @CurtinMRI and @TheKids_AU
Perth, Western Australia
Joined November 2017
The discovery of CRYAB as the binding partner of TANGO2 highlights the importance of intermediate filaments in metabolism and mitochondrial function and reveals the molecular basis of TANGO2 deficiency disorder (TDD).#metabolism.#mitochondria.@NatureComms
1
2
12
RT @FilipovskaLab: It takes two to TANGO2!. TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermedia….
0
2
0
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia?.Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable.
4
5
15
RT @FilipovskaLab: New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability….
0
2
0
Destroyer turned protector - FASTKD4 uses it’s Vsr nuclease-like structure to protect the polyadenylated tail of the mitochondrial MT-ND3 mRNA. #RNA.#mitochondria.#mtDNA
1
8
45
RT @LazarouLab: Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data….
0
35
0
Better CRISPR base editors!.More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases. @ACSSynBio.
0
7
16
Organelles within mammalian cells are surprisingly interconnected, and lipids play a critical role. Check out: Interorganelle phospholipid communication, a house not so divided @Trends_Endo_Met to see more. #metabolism.#mitochondria.#lipids.#Golgi.#ER
0
5
18
RT @Trends_Endo_Met: Online Now: Interorganelle phospholipid communication, a house not so divided #trends #endocr….
0
1
0
0
5
31
RT @TrendsCellBio: Unique architectural features of mammalian mitochondrial protein synthesis .
0
1
0
RT @FilipovskaLab: Unique architectural features of mammalian mitochondrial protein synthesis.30-day free access to our new review at: http….
0
18
0
High-fidelity Cas9 variants that prevent off-target cleavage typically reduce on-target activity. Adding TurboCas9 mutations to these enzymes can improve activity while maintaining off-target fidelity. @CellRepMethods.
1
7
25
RT @CellRepMethods: Mutational rescue of the activity of high-fidelity Cas9 enzymes
www.cell.com
Many Cas9 variants have been engineered to prevent off-target cleavage; however, these high-fidelity enzymes typically do so at the expense of on-target activity. Vos et al. demonstrate that layering...
0
2
0
RT @pascal_d_vos: Are you tired of slow gene editing and scattershot targeting? . Well no more, here we introduce HyperDriveCas9. An engine….
0
2
0
RT @NatureCellBio: 💫NEW: @FilipovskaLab & co use 3D cell reconstruction of focused ion beam scanning electron #microscopy data and #multiom….
0
8
0
RT @FilipovskaLab: Quantitative volumetric analyses and morphological interactions supported by multi-omic profiling identify global organe….
0
33
0
Check out this elegant News and Views @NatureCellBio by Antentor Hinton Jr @phdgprotein86 and Andrea Marshall @DrDreNeuroWay, highlighting the importance of organelle interconnectivity:.
0
7
30
“I am a part of all that I have met” – Ulysses; Alfred Tennyson. CRISPR screening, volumetric EM and multi-omics reveal the highly connected nature of organelles. Defects in peroxisomes, Golgi and the ER converge on mitochondria via the lipidome.
1
11
50
RT @AAMRI_Aus: A new report has found that medical research in WA:.🇦🇺Returns $2.61 to Aus for every $1 invested.💼Added 2,632 jobs to WA in….
0
6
0