Tumour Immune Microenvironment Lab
@TaurielloLab
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Fresh lab @Radboudumc @RIMLSinstitute. / tweets by @TaurielloD
Nijmegen, Nederland
Joined December 2018
Congratulations and thanks for the collaboration!
Great work from PhD students Jelmer Dijksta and @HNeikes in collaboration with @TaurielloLab and Emile Voest: multi-omics and secretomics in tumor progression organoids revealing putative regulators of colon cancer metastasis, including DKK3 and DKK4 https://t.co/wnpLRHcG2F
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Our own Beatriz Subtil wrote a blog about the importance of #rest for academics, inspired by the work of @DrDaltonSmith. Have a look: https://t.co/rrW1C93tVp "...by prioritizing our rest and well-being, we become more productive, present, creative, motivated, and focused."
radboudumc.nl
24 February 2022
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#WorldCancerDay, has many meanings to patients, survivors, family, friends, grievers... Besides sharing these, scientists also try to take strength and inspiration from today. Join or support our @TranslCRCres #Walkagainstcancer
https://t.co/ed4a3DkhSN
@ROFNijmegen @radboudumc
radboudoncologiefonds.voorradboudfonds.nl
A fundamental understanding of the disease for better care and outcomes // Een fundamenteel begrip van de ziekte, voor betere zorg en levenskwaliteit. On April 16th we walked a beatuful route from...
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NEW Review! @TaurielloD from @TaurielloLab, @elenasanchosuil and @BatlleLab discuss overcoming #TGFbeta-mediated immune evasion in cancer. ⚡ https://t.co/fxFTaX1ZIZ
@natrescancer #CancerTherapy #CancerImmunity
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As tumours progress, TGFβ drives strong wound-healing programme in CAF & suppress the adaptive & innate immune system, thus facilitating #immunotherapy insensitivity.Overcoming TGFβ-mediated immune evasion in cancer is a difficult but important challenge. https://t.co/UvQv4cpXNN
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With @TaurielloD from @TaurielloLab and @elenasanchosuil we have written this comprenhensive review on the role of TGF-beta over immune cell types in the TME, and the actual landscape of therapies targeting this pathway in #Cancer for @NatureRevCancer
https://t.co/3Rr805NbiV
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NEW content online! Overcoming TGFβ-mediated immune evasion in cancer https://t.co/vns4d1w2tt
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Together with @BatlleLab, @elenasanchosuil, I wrote a review on Overcoming TGFβ-mediated immune evasion in cancer in @NatureRevCancer. We are very proud of this, and I hope you will enjoy reading it. https://t.co/c2Ff5WiXKy
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If you like #CRC and #immunity, you might want to check out DC (dys)function ... which is exactly what Beatriz Subtil in the lab is doing. And she wrote a beautiful review about it too! With @AlessandraCambi + Jolanda de Vries @TIL_Radboudumc Out today: https://t.co/oEsR7YChLh
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New group photo from our recent and wonderful lab retreat (together with Henk Verheul & co)
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Congrats! to collaborators in the Moscat—Diaz-Meco lab @SBPdiscovery/@WeillCornell, for their publication on TGFB-induced suppression of PKCZ in the CRC #TME—promoting SOX2-mediated #CAF formation; using our @BatlleLab MTOs. 👉Kasashima et al. @Dev_Cell
https://t.co/s1qM20UPgP
cell.com
Kasashima et al. describe a molecular mechanism whereby the loss of PKCζ in the stroma upregulates SOX2 to activate the reprogramming of colonic fibroblasts generating a SFRP1/2-expressing CAF...
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Happy to share our latest publication in @embojournal ! We discovered an unexpected class of RNF43 mutations that confer a tumor suppressor-to-oncogene switch. Curious how? Check our video summary 👉 https://t.co/A1Zmmwrk8j
@UMCU_CMM @oncodeinstitute 1/4
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Combinatorial #Immunotherapies for #Metastatic #Colorectal #Cancer by Eline Janssen, Beatriz Subtil et al. 👉 https://t.co/EZqXmuO5w5
#CRC
#immunesuppression
#tumormicroenvironment
mdpi.com
Colorectal cancer (CRC) is one of the most frequent and deadly forms of cancer. About half of patients are affected by metastasis, with the cancer spreading to e.g., liver, lungs or the peritoneum....
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My lab's first publication is a fact! Huge kudos to Eline Janssen, Beatriz Subtil & Fàtima de la Jara Ortiz for pulling this off in these weird times, well done! Also thanks to our super-collaborator Henk Verheul @radboudumc. May this be the first of many to come! 🥳🎉🥂
Interested in #ColorectalCancer research & #Immunotherapy? Our review offers an overview of the field, plus a perspective towards 'precision I/O': Combinatorial Immunotherapies for Metastatic CRC https://t.co/BW1NSyEnYx via @MDPIOpenAccess @radboudumc_weetn @RIMLSInstitute
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As this is the TiMElab's first-TiME publication, this one is very special to us. We learned a lot from researching and writing it, and feel it made something positive out of the Covid-19 lockdown in the process. Above all, we hope you find it useful!
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Interested in #ColorectalCancer research & #Immunotherapy? Our review offers an overview of the field, plus a perspective towards 'precision I/O': Combinatorial Immunotherapies for Metastatic CRC https://t.co/BW1NSyEnYx via @MDPIOpenAccess @radboudumc_weetn @RIMLSInstitute
mdpi.com
Colorectal cancer (CRC) is one of the most frequent and deadly forms of cancer. About half of patients are affected by metastasis, with the cancer spreading to e.g., liver, lungs or the peritoneum....
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Great to see the department of #cellbiology @RIMLSInstitute @radboudumc back together again ... celebrating publications, awards and life in general 🍾 #anderhalvemeter #picnic
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And that's a wrap on our #RNAseq course for @CAMBUpenn! Great group of students this year. 21hrs of video lectures are up on our website for anyone who wants self-guided instruction in #rstats and @bioconductor.
diytranscriptomics.com
A full course covering best practices for RNAseq data analysis, with a primary focus on empowering students to be independent in the use of lightweight and open-source software and the R/bioconductor...
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This is a cautionary tale of how anti-Spike antibody may make COVID disease worse. In this study, the authors show that anti-Spike IgG made SARS-CoV disease worse by switching macrophage from wound-healing to proinflammatory phenotype. A thread (1/n) https://t.co/T8ipHt5tRH
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#ibiology recorded three lectures of 20 minutes each covering 30 years or research in my lab. They can be viewed at: https://t.co/QbysC0TdcU
#stemcells #organoids @coloncancer
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