Susan Bal
@SusanBal9
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Plasma Cell Disorders; Tx/Cell Therapy Physician @ UAB Medicine via Memorial Sloan Kettering; U of Cincinnati & Kettering; Tweets=My opinions #mmsm
Birmingham, AL
Joined March 2017
Thank you for the invitation @szusmani and Sham Mailankody to join this fantastic meeting, really great presentations and discussion.
We're so excited to be at the inaugural #iwGPRC5D2025 Workshop! We'll be hearing about all things related to GPRC5D-targeted myeloma therapies - stay tuned for more. Chaired by @szusmani & Sham Mailankody. #MMsm #HemOnc
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The funnest talk from @JoshuaRichterMD and a new acronym for neurotoxicity with gprc5d #iwgprc5d2025
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Thank you for sharing and thanks to @TheLancetHaem for the opportunity to pen this commentary on an important update of a major practice informing - monumental study.
Monumen-TAL progress in the treatment of relapsed multiple myeloma -.Ongoing drug development of novel agents and deployment of innovative combinations remains paramount in chasing the elusive cure. The Lancet Haematology #mmsm.
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We showed identical MRD responses as Quadruplet+ASCT and were able to spare a quarter of patients the toxicity of ASCT. Important to follow long term outcomes but so far so good! Larger studies Master-2 and MIDAS if further answer this and other important qs. But it can be done!
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At #IMS2024 we shared the first results from a pilot study of real time MRD-adapted deferral of ASCT in #mmsm absolutely could not have done this without the support of @End_myeloma and our fantastic MM team @uabmedicine
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No pressure right! Debating @Myeloma_Doc.
Amazing debate by @Myeloma_Doc and @SusanBal9 about which antigen to use post BCMA Rx: BCMA versus other? .#GDUHem
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Thanks @GKaurMD for the amazing kebabs delivered since she couldn’t take me out while in Dallas, the sweetest 🥹🫠
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Imp manuscript from the Mayo group @ZanwarSaurabh showing the outcomes of pts w/ suboptimal response to DaraVCd in NDAL. I have traditionally switched to BCL2 inhibition ASAP if t(11;14) but for the rest such a tricky spot! Hopeful for TCE in this popn.
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Wonderful morning discussing the importance of MRD in high risk MM especially on the heels of the ODAC.
#DukeDebates in #mmsm .@SusanBal9 vs Dr Raymond Thertulien on induction and MRD for high risk.Dr Cristiana Chase vs Dr Taewoong Choi on CAR T vs transplant in relapsed MM
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Always great to listen to my previous co-fellow @UrviShahMD talk passionately about nutrition and myeloma
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Excellent thread on cilta-cel, only point I would highlight is if you progress on bridging therapy, your risk of fatal outcome 🔝 and in that situation I would not proceed directly with cilta cel but consider other options to lower disease burden!.
#mmsm .How to counsel patients about Cilta Cel using the data from.CARTITUDE-4 and FDA ODAC meeting for earlier use. With data of Cilta cel and Ide cel, assuming having access to both for a given patient, I will personally chose Cilta cel (I explained this before) . 🧵.
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When we presented this at EHA, less apparent but important to await data from additional patients and f/u at RP2D
Interesting kinetic profile of GPRC5D CART cells- (n=26) hence preliminary.- biphasic ?.- higher median at 6 months than ide-cel ( will this persistence translate to longer PFS ).(Sadly all cilta-cel articles are behind a paywall @JanssenUS ).#ASH23
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Fantastic time as always connecting with friends, mentors sharing and learning amazing science @ASH_hematology @NBahlis @kordeneha1 @OmarNadeemMD Dr. Zelenetz
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Encouraging early data showing IMiDs and possibly CelMODs can improve on the response to immunotherapy @MileHighMyeloma @End_myeloma
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Applaud the massive effort @mtmdphd undertakes every year to give us a glimpse of the best of #mmsm at @ASH_hematology and grateful to be included on this list!.
Myeloma / Plasma Cell Dyscrasia ~ #ASH23Top10 (or so) #mmsm #mmMRD #ASH23 - @mtmdphd *DRAFT* Table Update: Nov 28, 2023 cc @grpetersen1 & @MyelomaTeacher @szusmani
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So many things to be grateful for but most thankful this year for my lil turkey! .Happy Thanksgiving to all.
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An impassioned talk by the eloquent @SagarLonialMD about how to get to CURE using available immunotherapies
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