RT @LyssiotisLab: 🔥Hot paper alert 🔥 .New one from @zeribechike, Matt Ward, @Sajjakulnukit, Pawan Poudel, et al. out today @Nature #OpenAcc….

RT @YatrikShahLab: What an incredible event! The Rogel Cancer Center's 'One Day Closer' brought in local students and their parents to lear….

RT @AGA_Gastro: Amino acids and there sensing pathways are essential in colon cancer growth @SumeetASolanki @YatrikShahLab ➡️ https://t.co/….

@LironBarPeled @DMSabatini Thank you so much @DMSabatini for your wishes. Here is the link for it

6/6 # Big thanks to @AmerGastroAssn, @AGA_Gastro, for outstanding editorial team. Big thanks to my outstanding mentor for his support @YatrikShahLab, collaborators Dr. Jun Hee Lee, @_Beam_On. Thanks to @UMRogelCancer, @UMPhysiology and @nicfawcett for beautiful write up.

5/6 # These findings are in line with reports @abielska (Craig Thompson’s group) and a similar concept (demand vs supply) reported by @AlexValvezan and @Manning_BD

4/6 # Colon tumors addicted to increased mTORC1 caused by disruption of amino acid sensing pathways are highly susceptible to cell death under amino acids limiliting conditions by a low protein diet.

3/6 # Dysregulation of amino acid sensing limits response to standard of care therapies for colon cancer.

2/6 # Low frequency of mutations and dysregulated expressions of GATOR1 complex proteins were found in colon cancer patients and this correlated with poor survival of CRC patients.

Excited to share cool findings in our recent article. Amino acid sensing complex, GATORs were first discovered by @LironBarPeled and @DMSabatini group. 1/6 # We show that colon tumors deregulate GATORs to boost mTORC1 and drive tumors in vivo.