Song Lin Lab
@SongLinLab
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Electrifying organic chemistry since 2016 | Cornell University | For group updates, find us on LinkedIn!
Ithaca, NY
Joined May 2017
Electrochemical synthesis goes wireless @Nature! Congrats to Bartosz, @JonasRein_ and our friends in the McEuen lab. We’d like to also thank the Lennox Group for their highlight on SPECS:
nature.com
Nature - High-throughput electrochemistry driven by microelectronic devices.
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Electrochemical reactions for organic synthesis typically require intricate, specialized equipment, slowing progress in this field. Minuscule electric generators now enable faster reaction discovery and development
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@SongLinLab I suSPECt this will be incredibly useful, nice work🫶
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Super excited to see our wireless electrosynthesis microchips in @Nature! SPECS make electrochemical reaction setup as easy as adding SPECS to a reaction and shining light on it! https://t.co/FFchfFmrnq
nature.com
Nature - A method to produce wireless microelectronic devices powered by light using standard nanofabrication techniques is described to convert any traditional 96-well or 384-well plate into an...
Organic synthesis meets nanofabrication! Introducing SPECS: light-powered microchips that turn any well plate into a wireless high-throughput electrosynthesis reactor at the µL scale. Ideal for reaction discovery, optimization, and library synthesis!
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Organic synthesis meets nanofabrication! Introducing SPECS: light-powered microchips that turn any well plate into a wireless high-throughput electrosynthesis reactor at the µL scale. Ideal for reaction discovery, optimization, and library synthesis!
nature.com
Nature - A method to produce wireless microelectronic devices powered by light using standard nanofabrication techniques is described to convert any traditional 96-well or 384-well plate into an...
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All good things come in pairs😉 We’re excited to see these works out in @J_A_C_S today! Check them out: https://t.co/PVIGxLM6Qn
https://t.co/8blCAPafv2
pubs.acs.org
Hydride abstraction represents a promising yet underexplored approach in the functionalization of C–H bonds. In this work, we report the oxidation of α-C–H bonds of ethers via oxoammonium catalysis...
No hydridic C–H bond is safe! Back to back in @ChemRxiv today, we report oxoammonium catalyzed oxidation of N-substituted amines and ethers! Featuring high TON, 100 g scale-up, a novel NMR experiment for radical quantification, & QSPR! (1/3)
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Farewell’s are also in order for our beloved post-docs Chenfei, Pierre-Louis and Bartosz🥹We’re sad to see you go, but can’t wait for what your new careers will have in store! Congrats!
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We are thrilled to welcome five stellar 1st year students to the Lin Lab! Congrats to Bofei, Nayan, Evan, Joe and Xiaowei! Here’s to new friends and great science ahead🤩⚡️
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Nothing brightens up a Monday morning like a successful PhD defense! Congratulations to the incredible Dr. @Zhipengluu🤩 Wishing you the best of luck as you begin your career @TakedaPharma 🎉
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Super happy to share these two works by our aminoxyl team: Oxoammonium catalyzed hydride abstraction for selective C–H oxidation!
No hydridic C–H bond is safe! Back to back in @ChemRxiv today, we report oxoammonium catalyzed oxidation of N-substituted amines and ethers! Featuring high TON, 100 g scale-up, a novel NMR experiment for radical quantification, & QSPR! (1/3)
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Call for Papers for Joint Special Issues in Tetrahedron Letters and Tetrahedron in honor of Prof. Eric Jacobsen and Prof. Song Lin. @songlin_chem @JacobsenLab For more information Check out: https://t.co/kXHqtzJuDU
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@YukunCheng1 developed the catalytic oxidation of weakly hydridic ethers with either mCPBA or e-chem⚡️. Through a novel relaxometry based NMR experiment for in-situ radical quantification, we unraveled the delicate equilibria among multiple resting states!
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@JonasRein_ and Bartosz developed a catalytic, mild, and selective oxidation of N-substituted amines through HTE and stereoelectronic tuning of aminoxyl radicals. With the help of @BoehringerUS, we then scaled up in batch and flow! https://t.co/YIODyTUN8e (2/3)
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No hydridic C–H bond is safe! Back to back in @ChemRxiv today, we report oxoammonium catalyzed oxidation of N-substituted amines and ethers! Featuring high TON, 100 g scale-up, a novel NMR experiment for radical quantification, & QSPR! (1/3)
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α,β-Desaturation & Formal β-C(sp3)–H Fluorination of N-Substituted Amines: Late-Stage Functionalization Enabled by Electrochemistry | JACS @songlin_chem @songlinlab @Cornell @TotalSyntheses #Desaturation #Fluorination #Amines #Electrochemistry #LateStage
pubs.acs.org
Incorporation of C(sp3)–F bonds in biologically active compounds is a common strategy employed in medicinal and agricultural chemistry to tune pharmacokinetic and pharmacodynamic properties. Due to...
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ShoNo? More like ShoYes! Now in @J_A_C_S, an electrochemical protocol for α,β-desaturation of N-substituted amines, providing convenient access to β-C–H fluorinated products! A phenomenal group effort by Luiz, Justin, Kaining & our friends at @Genentech⚡️
pubs.acs.org
Incorporation of C(sp3)–F bonds in biologically active compounds is a common strategy employed in medicinal and agricultural chemistry to tune pharmacokinetic and pharmacodynamic properties. Due to...
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Past and present Lin Lab members Lingxiang, Samson, Cindy and Bartosz are charged up for this year’s Stereochem GRC!⚡️
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Congrats to Dr. @JonasRein_ on a phenomenal PhD defense! A brilliant mind, asymmetric catalysis wizard, and exceptional mentor, your guidance has been invaluable to us all⚡️🧑💻Here's to your well-deserved success and many future achievements to come!
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Rising 2nd year Sukwoo also gave an awesome department seminar on his contributions to this work! We are SO proud🤩 Watch out for more to come from this superstar🎉
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Out now in @J_A_C_S! @ju_minsoo, Sukwoo and Halle describe a convenient approach for accessing frustrated radical pairs from tertiary alcohols. We had so much fun scaling up & elaborating our FRP chemistry towards complex molecule synthesis! Check it out:
pubs.acs.org
Alkoxy radicals are versatile reactive intermediates in organic synthesis. Here, we leverage the principle of frustrated radical pair to provide convenient access to these highly reactive species...
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