Jacobsen Lab
@JacobsenLab
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Student-run Twitter account for the Jacobsen Group @HarvardCCB | Tweets by Eric signed ENJ
Cambridge, MA
Joined June 2020
Excited to share our work, now published in JACS, on merging gold and chiral H-bond donor catalysis! Eric Jacobsen and I show that a chiral urea cocatalyst activates an achiral gold catalyst to enable asymmetric spirocyclization of naphthols. @JacobsenLab
https://t.co/okrQf4JPRo
pubs.acs.org
We report the enantioselective gold(I)-catalyzed dearomative spirocyclization of naphthols enabled by the cooperative effect of chiral dual hydrogen-bond donors (HBDs). The reaction affords carbocy...
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https://t.co/O9dMXcwnzD Wonderful new paper from @JacobsenLab ! Metal salens can do it all!
pubs.acs.org
β-Glucuronidation is an important metabolic pathway for a variety of chemicals, including drugs and endogenous substances. We report here that simple (salen)cobalt and (salen)chromium complexes...
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(Salen)Metal-Catalyzed β-Glucuronidation of Alcohols, Phenols, and Anilines | Journal of the American Chemical Society @Harvard @HarvardCCB @JacobsenGroup
pubs.acs.org
β-Glucuronidation is an important metabolic pathway for a variety of chemicals, including drugs and endogenous substances. We report here that simple (salen)cobalt and (salen)chromium complexes...
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Meet the Team: Andrew Yue (UIUC BS 2024, now grad student @JacobsenGroup) joined the MCWhite group as a freshman under mentorship of Brenna Budaitis. He merged C(sp3)H/N(sp2) cross-couplings with the Mori-Ban for a diversifiable synthesis of zafirlukast (Accolade).
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Presentation of the Roger Adams Award Medal to Prof. Jacobsen (@JacobsenLab )! @MaleczkaC gave an overview of @OrgReactions and The RA Award followed by introduction of Eric by @JohnWoodGroup. Congratulations Eric! @ACSorganic @OrgSynth #NOS2025
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Packed house for @HarvardCCB Eric Jacobsen’s wonderful student-invited lecture on “Privileged Chiral Catalysts.” Thanks for spending your day with @PrincetonChem, Eric!
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Many thanks to https://t.co/uLb5Gmd4bz and the fabulous Angie @angierangeles for inviting us to the DOC dinner and allowing us to spend a memorable evening celebrating with friends from @JacobsenLab @Stephenson_Lab @SchindlerLab
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The University of Chicago Department of Chemistry is honored to welcome Professor Eric Jacobsen, Sheldon Emery Professor of Chemistry at Harvard University, as the distinguished speaker for the Kharasch Lectures on April 1st, 2nd, and 3rd. Prof. Jacobsen's work on asymmetric
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Research Highlight now online: Ring-opening of azetidines by @PSeavill
https://t.co/Z1VONqRSpR ($) Highlighting the @J_A_C_S article by Eric Jacobsen & co-workers @JacobsenLab
nature.com
Nature Synthesis - Ring-opening of azetidines
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Enantioselective Ring Opening of Azetidines via Charge Recognition in Hydrogen-Bond-Donor Catalysis | Journal of the American Chemical Society @Harvard @HarvardCCB @TotalSyntheses
pubs.acs.org
We report the highly enantioselective ring-opening of 3-substituted azetidines by alkyl and acyl halides promoted by a chiral squaramide hydrogen-bond donor catalyst. Broad scope is achieved across a...
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Congrats to Joseph @JosephJGair1, Mayuko, Corin & Daniel @JacobsenLab @HarvardCCB 😀😀 https://t.co/cTPXZnTB81
@J_A_C_S #crystallography
pubs.acs.org
We report the highly enantioselective ring-opening of 3-substituted azetidines by alkyl and acyl halides promoted by a chiral squaramide hydrogen-bond donor catalyst. Broad scope is achieved across a...
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Have you ever wondered how different substituents affect cation–π vs. π–π vs. CH–π vs. anion–π interactions? Well, now you can read all about it! Very excited to have this work with @Sigman_Lab and @JacobsenLab out in the world @JOC_OL #ACSEditorsChoice
A very exciting study from Jacquelyne Read, Eric Jacobsen, and Matthew Sigman in #JOrgChem: development of a computational library and automated analysis tool for assessing and predicting Noncovalent Interactions (NCIs). Selected for #EditorsChoice
https://t.co/XW908PLtmz
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A very exciting study from Jacquelyne Read, Eric Jacobsen, and Matthew Sigman in #JOrgChem: development of a computational library and automated analysis tool for assessing and predicting Noncovalent Interactions (NCIs). Selected for #EditorsChoice
https://t.co/XW908PLtmz
pubs.acs.org
A quantitative and predictive understanding of how attractive noncovalent interactions (NCIs) influence functional outcomes is a long-standing goal in mechanistic chemistry. In that context, better...
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Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enables Selective Synthesis of Benzestrol Isomers @Harvard @HarvardCCB #Iterative #Diastereoselective #Matteson #Homologations #Synthesis #Benzestrol @TotalSyntheses @TotalSynthesis
pubs.acs.org
We report the development of an iterative Matteson homologation reaction with catalyst-controlled diastereoselectivity through the design of a new catalyst. This reaction was applied to the selective...
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Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enables the Selective Synthesis of Benzestrol Isomers (@J_A_C_S): https://t.co/R9ADhHlk7A (@JacobsenLab).
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Sweet work by Queen B @SamanthaAngle1 @JacobsenLab on catalyst-ctrl'd iterative Matteson homologations! Feat. selective synthesis of all permutations of the stereotriad Benzestrol. Feel lucky to have been a small part of this story, @Merck got a good one!
pubs.acs.org
We report the development of an iterative Matteson homologation reaction with catalyst-controlled diastereoselectivity through the design of a new catalyst. This reaction was applied to the selective...
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Had an amazing time at the Welch conference! Congratulations to Prof. Eric Jacobsen on receiving the 2024 Robert A. Welch Award in chemistry! @WelchFoundation Shoutout Grandpa Buchwald @BuchwildGroup
#buchwaldbowtie
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Eric N. Jacobsen, the 2024 recipient of the prestigious Robert A. Welch Award in Chemistry, received his award at the Welch Award Reception and Dinner on October 21, 2024 at The Post Oak Hotel at Uptown Houston.
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Call for Papers for Joint Special Issues in Tetrahedron Letters and Tetrahedron in honor of Prof. Eric Jacobsen and Prof. Song Lin. @songlin_chem @JacobsenLab For more information Check out: https://t.co/kXHqtzJuDU
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Be sure to check out the latest installment of our Advanced Organic Chemistry course, where Dr. Katherine Forbes @KCFchemistry @JacobsenLab gives us an intro to phosphorus (V) chemistry!! Thanks to Andy for hosting! Link: https://t.co/J3J68fsx6u
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