Shift Bioscience
@ShiftBioscience
Followers
1K
Following
632
Media
17
Statuses
126
Reversing aging by cell rejuvenation
Cambridge UK
Joined December 2017
I'm excited to be speaking at @RNID's Hearing Therapeutics Summit 2025, which is helping to speed the development of therapeutics for hearing loss and tinnitus. With a strengthening link between age related hearing loss and the underlying aging process, hearing loss has become a
0
1
3
AI Virtual Cell vs Linear Modelโwho wins? ๐ค โ๏ธ ๐ Our preprint, entitled "๐๐ฆ๐ฆ๐ฑ ๐๐ฆ๐ข๐ณ๐ฏ๐ช๐ฏ๐จ-๐๐ข๐ด๐ฆ๐ฅ ๐๐ฆ๐ฏ๐ฆ๐ต๐ช๐ค ๐๐ฆ๐ณ๐ต๐ถ๐ณ๐ฃ๐ข๐ต๐ช๐ฐ๐ฏ ๐๐ฐ๐ฅ๐ฆ๐ญ๐ด ๐๐ฐ ๐๐ถ๐ต๐ฑ๐ฆ๐ณ๐ง๐ฐ๐ณ๐ฎ ๐๐ฏ๐ช๐ฏ๐ง๐ฐ๐ณ๐ฎ๐ข๐ต๐ช๐ท๐ฆ ๐๐ข๐ด๐ฆ๐ญ๐ช๐ฏ๐ฆ๐ด ๐ฐ๐ฏ ๐๐ฆ๐ญ๐ญ-๐๐ข๐ญ๐ช๐ฃ๐ณ๐ข๐ต๐ฆ๐ฅ
0
3
9
๐ Weโre hiring a Computational Biologist (Toronto) Atย Shift Bioscience, weโre uncovering the biology of cell rejuvenation to develop safe, effective therapies that reverse cellular aging ๐งฌ . Our platform integratesย single-cell biologyย andย machine learningย to identify and
0
2
8
What is the state of research on the emerging grand challenge of virtual cell modeling? 1/n https://t.co/lOm7d8nd0g
2
11
104
Do deep generative models in single-cell omics really work for perturbation prediction? Some benchmark studies say yes: ๐ https://t.co/gFYx4SMHXQ ๐ https://t.co/oBR3p5AetT Others say no: ๐ https://t.co/KhgEIgKIeD ๐ BMC Genomics: https://t.co/X1OkXeaErB To move beyond this
2
49
216
Are you trying to build a so-called AIย virtual cell? ๐ฌ Yet ... the mean still outperforms your perturbation-response prediction model. ๐ฎโ๐จ Our paperโ just accepted to the ๐๐ฒ๐ป๐๐ถ๐ผ ๐ช๐ผ๐ฟ๐ธ๐๐ต๐ผ๐ฝ @ ๐๐๐ ๐ โdives into ๐ธ๐ฉ๐บ the mean excels and what you can do about it.
1
30
126
RT @dives86: @ShiftBioscience proposes an improved ranking system for virtual cell models to accelerate gene target discovery and drive rejโฆ
0
1
0
๐ New LEVITY episode is live! Why tune in? Because a 24-person Cambridge startup may have beaten the billion-dollar OSK race with a single gene found by AI-powered virtual cells - and the early data look game-changing. (Links as always below.) Just about the hottest thing in
7
20
82
Thankyou @peterottsjo and @DrPatrickLinden for hosting me on the LEVITY @reachlevity podcast to discuss our preprint 'A single factor for safer cellular rejuvenation' and beyond!
2
10
31
RT @dives86: @SheekeyScience breaks down the @ShiftBioscience preprint 'A single factor for safer cellular rejuvenation' highlighting bothโฆ
0
2
0
Genuine epigenetic rejuvenation in primary cells has long been the holy grail. Aย groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated
biorxiv.org
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the...
33
105
538
Single-gene rejuvenation target promises safer cell age reversal @ShiftBioscience #longevitybiotech #aging
https://t.co/67fdGF4FBe
2
18
55
Rare moments make you stop, stare, and imagine their future impact. Iโm thrilled to share one of those moments from our work at @ShiftBioscience. Over the last few years, the data often felt unreal. Today we compare the single-gene SB000 (Shift Bioscience 000) with the
13
27
138
RT @dives86: The dream of waking up in the near future and being substantially younger at a cellular level is something I have the rare priโฆ
biorxiv.org
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the...
0
4
0
Iโm excited to welcome Lord David Prior and Sir Tony Kouzarides to the team at @ShiftBioscience! Joining as Chair of the Board, David brings a wealth of Board experience, including as Chairman of NHS England, to support the Companyโs long term mission to comprehensively reverse
0
2
18
I'll be speaking at Founders Longevity Forum in London on 10th June at OXO2! Letโs connect in London โ whether you're building something new in Longevity biotech, investing in the future, or just curious about where the field is going next. Register your interest here:
0
1
6
Iโm excited to be part of a #SynBioBeta2025 panel discussing breakthroughs in epigenetic reprogramming and how this could transform Longevity biotech. Letโs connect in San Jose โ whether you're building the next big thing in Longevity biotech, investing in the future, or just
0
2
7
1/ We're thrilled to announce Shift Bioscience @ShiftBioscience as a sponsor of Vitalist Bay - our 8-week longevity zone dedicated to combating aging at the cellular level using groundbreaking AI technology. ๐ฌ๐งฌ๐ป
1
3
23
Iโm excited to welcome Dr Jill Reckless and Dr Laurence Reid @laurence_reid to the Shift Bioscience team as Translation Advisor and Non-Executive Director respectively, to help advance our pipeline of rejuvenation therapeutics! Aging mechanisms are common to the majority of
0
1
13
Shift Bio is leading the way in using foundation models for rejuvenation research! Excited to see the breakthroughs theyโll bring in the years ahead!
Iโm excited to share that Shift Bioscience is expanding to North America to increase its capabilities in AI-powered virtual cells and their use for discovery of rejuvenation genes. Shift's Head of Machine Learning, Lucas Camillo @ollimacsacul, will be relocating to Toronto,
1
8
30