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Shift Bioscience

@ShiftBioscience

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Reversing aging by cell rejuvenation

Cambridge UK
Joined December 2017
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@dives86
Daniel Ives
1 month
I'm excited to be speaking at @RNID's Hearing Therapeutics Summit 2025, which is helping to speed the development of therapeutics for hearing loss and tinnitus. With a strengthening link between age related hearing loss and the underlying aging process, hearing loss has become a
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@lucascamillomd
Lucas Camillo
2 months
AI Virtual Cell vs Linear Modelโ€”who wins? ๐Ÿค– โš”๏ธ ๐Ÿ“ˆ Our preprint, entitled "๐˜‹๐˜ฆ๐˜ฆ๐˜ฑ ๐˜“๐˜ฆ๐˜ข๐˜ณ๐˜ฏ๐˜ช๐˜ฏ๐˜จ-๐˜‰๐˜ข๐˜ด๐˜ฆ๐˜ฅ ๐˜Ž๐˜ฆ๐˜ฏ๐˜ฆ๐˜ต๐˜ช๐˜ค ๐˜—๐˜ฆ๐˜ณ๐˜ต๐˜ถ๐˜ณ๐˜ฃ๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜”๐˜ฐ๐˜ฅ๐˜ฆ๐˜ญ๐˜ด ๐˜‹๐˜ฐ ๐˜–๐˜ถ๐˜ต๐˜ฑ๐˜ฆ๐˜ณ๐˜ง๐˜ฐ๐˜ณ๐˜ฎ ๐˜œ๐˜ฏ๐˜ช๐˜ฏ๐˜ง๐˜ฐ๐˜ณ๐˜ฎ๐˜ข๐˜ต๐˜ช๐˜ท๐˜ฆ ๐˜‰๐˜ข๐˜ด๐˜ฆ๐˜ญ๐˜ช๐˜ฏ๐˜ฆ๐˜ด ๐˜ฐ๐˜ฏ ๐˜ž๐˜ฆ๐˜ญ๐˜ญ-๐˜Š๐˜ข๐˜ญ๐˜ช๐˜ฃ๐˜ณ๐˜ข๐˜ต๐˜ฆ๐˜ฅ
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@Henrymiller2012
Henry E. Miller
2 months
๐Ÿš€ Weโ€™re hiring a Computational Biologist (Toronto) Atย Shift Bioscience, weโ€™re uncovering the biology of cell rejuvenation to develop safe, effective therapies that reverse cellular aging ๐Ÿงฌ . Our platform integratesย single-cell biologyย andย machine learningย to identify and
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@wilstc
Will Connell
5 months
What is the state of research on the emerging grand challenge of virtual cell modeling? 1/n https://t.co/lOm7d8nd0g
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@BoWang87
Bo Wang
6 months
Do deep generative models in single-cell omics really work for perturbation prediction? Some benchmark studies say yes: ๐Ÿ”— https://t.co/gFYx4SMHXQ ๐Ÿ”— https://t.co/oBR3p5AetT Others say no: ๐Ÿ”— https://t.co/KhgEIgKIeD ๐Ÿ”— BMC Genomics: https://t.co/X1OkXeaErB To move beyond this
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@lucascamillomd
Lucas Camillo
6 months
Are you trying to build a so-called AIย virtual cell? ๐Ÿ”ฌ Yet ... the mean still outperforms your perturbation-response prediction model. ๐Ÿ˜ฎโ€๐Ÿ’จ Our paperโ€” just accepted to the ๐—š๐—ฒ๐—ป๐—•๐—ถ๐—ผ ๐—ช๐—ผ๐—ฟ๐—ธ๐˜€๐—ต๐—ผ๐—ฝ @ ๐—œ๐—–๐— ๐—Ÿ โ€”dives into ๐˜ธ๐˜ฉ๐˜บ the mean excels and what you can do about it.
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@ShiftBioscience
Shift Bioscience
6 months
RT @dives86: @ShiftBioscience proposes an improved ranking system for virtual cell models to accelerate gene target discovery and drive rejโ€ฆ
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@peterottsjo
Peter Ottsjรถ
6 months
๐Ÿ†• New LEVITY episode is live! Why tune in? Because a 24-person Cambridge startup may have beaten the billion-dollar OSK race with a single gene found by AI-powered virtual cells - and the early data look game-changing. (Links as always below.) Just about the hottest thing in
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@dives86
Daniel Ives
6 months
Thankyou @peterottsjo and @DrPatrickLinden for hosting me on the LEVITY @reachlevity podcast to discuss our preprint 'A single factor for safer cellular rejuvenation' and beyond!
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@ShiftBioscience
Shift Bioscience
6 months
RT @dives86: @SheekeyScience breaks down the @ShiftBioscience preprint 'A single factor for safer cellular rejuvenation' highlighting bothโ€ฆ
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@prof_horvath
Prof Steve Horvath
6 months
Genuine epigenetic rejuvenation in primary cells has long been the holy grail. Aย groundbreaking preprint reveals that over-expression of a single (secret) gene overcomes this barrier: greatly reduced age estimates across in fibroblasts and keratinocytes according to validated
Tweet card summary image
biorxiv.org
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the...
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@LongevityTech
Longevity Technology
6 months
Single-gene rejuvenation target promises safer cell age reversal @ShiftBioscience #longevitybiotech #aging https://t.co/67fdGF4FBe
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@lucascamillomd
Lucas Camillo
6 months
Rare moments make you stop, stare, and imagine their future impact. Iโ€™m thrilled to share one of those moments from our work at @ShiftBioscience. Over the last few years, the data often felt unreal. Today we compare the single-gene SB000 (Shift Bioscience 000) with the
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@ShiftBioscience
Shift Bioscience
6 months
RT @dives86: The dream of waking up in the near future and being substantially younger at a cellular level is something I have the rare priโ€ฆ
Tweet card summary image
biorxiv.org
Ageing is a key driver of the major diseases afflicting the modern world. Slowing or reversing the ageing process would therefore drive significant and broad benefits to human health. Previously, the...
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@dives86
Daniel Ives
7 months
Iโ€™m excited to welcome Lord David Prior and Sir Tony Kouzarides to the team at @ShiftBioscience! Joining as Chair of the Board, David brings a wealth of Board experience, including as Chairman of NHS England, to support the Companyโ€™s long term mission to comprehensively reverse
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@dives86
Daniel Ives
8 months
I'll be speaking at Founders Longevity Forum in London on 10th June at OXO2! Letโ€™s connect in London โ€” whether you're building something new in Longevity biotech, investing in the future, or just curious about where the field is going next. Register your interest here:
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@dives86
Daniel Ives
8 months
Iโ€™m excited to be part of a #SynBioBeta2025 panel discussing breakthroughs in epigenetic reprogramming and how this could transform Longevity biotech. Letโ€™s connect in San Jose โ€” whether you're building the next big thing in Longevity biotech, investing in the future, or just
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@VitalistBay
Vitalist Bay (April 4 - May 29)
8 months
1/ We're thrilled to announce Shift Bioscience @ShiftBioscience as a sponsor of Vitalist Bay - our 8-week longevity zone dedicated to combating aging at the cellular level using groundbreaking AI technology. ๐Ÿ”ฌ๐Ÿงฌ๐Ÿ’ป
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@dives86
Daniel Ives
9 months
Iโ€™m excited to welcome Dr Jill Reckless and Dr Laurence Reid @laurence_reid to the Shift Bioscience team as Translation Advisor and Non-Executive Director respectively, to help advance our pipeline of rejuvenation therapeutics! Aging mechanisms are common to the majority of
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@BoWang87
Bo Wang
10 months
Shift Bio is leading the way in using foundation models for rejuvenation research! Excited to see the breakthroughs theyโ€™ll bring in the years ahead!
@dives86
Daniel Ives
10 months
Iโ€™m excited to share that Shift Bioscience is expanding to North America to increase its capabilities in AI-powered virtual cells and their use for discovery of rejuvenation genes. Shift's Head of Machine Learning, Lucas Camillo @ollimacsacul, will be relocating to Toronto,
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