Shasha Feng
@ShashaFeng3
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Comp chemist @Merck. Love arts & sciences. Comp chem. TRP channels, cheminformatics, ML, Mla lipid transporter. Alma mater @PKU1898 @lehighU
Bethlehem, PA
Joined August 2018
More light shed on how TRPM8 gets desensitized, paving the way for developing new generation of inhibitors. With the rich structural info, I bet the future of TRP channel pharmacology will be different. Congratulations to the team!.
🎉Our 4th research paper on the menthol and cold receptor TRPM8 is now published in @ScienceAdvances👉Mechanisms of TRPM8 Desensitization and Inhibition: After a challenging journey, we finally made it. I'm beyond thrilled and proud! #TRPM8 @dukebiochem.
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RT @ying__yin: 🎉Our 4th research paper on the menthol and cold receptor TRPM8 is now published in @ScienceAdvances👉Mechanisms of TRPM8 Dese….
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Computational chemistry Co-Op opportunity at Merck Research Lab working on peptides, please apply! .
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Interesting approach. From sequence to structure, we generally think it is learning the interactions and folding cores of protein residues. From structure to predict sequence, what is being learned? The space fulfillment ability of each residue? 🤔.
Here's a free link to the final version of this paper, where we stick PLM embeddings into an inverse folding model for representation learning!.
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RT @RDKit_org: Here's a reminder that registration for the 2023 RDKit UGM in Mainz is still open. We also still have some slots open for sp….
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Another TRPV4-RhoA work by @AlexanderSobol6 group also went online today, demonstrating RhoA binding interface plus ligand HC-067047. Efforts are emerging together and glad to know more ligand binds in VSLD
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In our recent TRPV4 work collaborated among 3 labs, we studied TRPV4-RhoA binding, binding of 3 drugs - GSK2798745 (w/ 4 clinical trials), GSK1016790A, 4a-PDD, and the modulation mechanisms. Happy to be part of the work!
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RT @AlHSJCKtEfpFXtm: We are so thrilled to share our latest research!.We revealed a new and intriguing GPCR activat….
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RT @lehighgsrs: We are finally here!🥳 Launching Graduate Students Research Series, a blog series that aims to share research by grad studen….
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RT @AlexanderSobol6: Happy to share structures of TRPM7 in the in the closed apo state, open conducting conformations activated by a gain-o….
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Congrats Jongdae!! I really enjoyed our discussions, it was a great collaboration experience 😇.
My first cryo-EM structure paper is finally published!. We show the molecular architecture of the first ion channel-Gα (not Gβγ) complex, TRPC5-Gαi3, and its function with PIP2.
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Our collaborative work on TRPC5 is now out - detailing cross-talk between Ga protein & PIP2. Happy to be part of the work!
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RT @yalun_yu: Our paper of the Drude2023 lipid force field is finally here! It would be a great tool to study membrane permeability and pol….
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Our club LU Graduate Students Outing Club (GSOC) made wonderful memories for 36 grads/postdocs during a 2021 Niagara Falls trip - many of them international. We want to make this happen again - please support us!!
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RT @CharmmGui: We are cautiously releasing the first chapter of QM/MM Interface, supporting CHARMM and AMBER with most semi-empirical QM me….
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Our review of @CharmmGui Membrane Builder is now out! We read > 1600 papers that used Memb Builder and summarized the applications. My biggest takeaway is that everything from DNA transfection to SNARE vesicle infusion to nanopore sequencing can now be studied in simulations🔬.
[ASAP] CHARMM-GUI : Past, Current, and Future Developments and Applications
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RT @JackGreisman: In a single long MD simulation we saw a loop change from a closed (red) to open (green) state, with many short "false ope….
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RT @MartinPeter91: 1/2 🚨Excited to share our latest preprint on TRAP-transporters!.We used disulfide cross-linking & single-molecule TIRF m….
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RT @KorkhovLab: Our work on Adenylyl cyclase 8 is now out on @biorxivpreprint 🥳 .In the manuscript (spearheaded by @BasurajSK & @dina_sch)….
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