Sensible Medicine
@Sensible__Med
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Sensible Medicine is a shared column featuring the voices of leading physicians, scientists and thinkers. We showcase ideas about all things medicine.
Joined July 2022
Sensible Medicine is Here! https://t.co/o0T7d3gyiS
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The Solution to Low Power is Not to Add Weak Endpoints: Lessons from the PARACHUTE HF trial in patients with Chagas Cardiomyopathy. You can't replicate PARADIGM HF by simply changing endpoints https://t.co/pgSQJOij5t via @drjohnm
sensible-med.com
Lessons from the PARACHUTE HF trial in patients with Chagas Cardiomyopathy. You can't replicate PARADIGM HF by simply changing endpoints
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Interesting ideas. The general principle here is that we do not know as much about neonatal HepB vaccination as we had been led to believe. Why not take the opportunity to understand the issue better? Randomize low-risk neonates to start vax on day 1 versus 2 months. Even better,
Maryland’s Department of Health (MDH) has explicitly recommitted to the universal birth dose, issuing a statewide standing order and advisory on December 5, 2025, to ensure continued vaccination. For instance, MDH Secretary Dr. Meena Seshamani stated: “The hepatitis B vaccine has
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The same "public health experts" who are now losing their minds over a minor change in @CDCgov HepB vaccine recommendation said nothing when some states and school districts forced student-athletes to wear rags soaked with sweat and condensed water vapor over their faces during
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Love this essay. A great take by a doctor in the making. Balancing Work and Life
sensible-med.com
The reality of work-life balance in medicine is that it's often no balance at all.
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"Vaccinated individuals had a 25% reduction in all cause mortality...similar...when excluding severe covid-19 death" On record saying covid vax in 2020-2022 is one of the greatest medical achievements ever But this is totally confounded Opposite of partisan science is rigor
Contrary to much of the nonsense you may read on here, mRNA vaccines don't cause deaths - they prevent them This massive study from France showed that not only did mRNA vaccines not increase mortality but they reduced deaths and saved lives
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It is all one life—rewarding, joyful, fulfilling. Wise words from a medical student, relevant at PGY23 and beyond Excellent @Sensible__Med post from Noah Hoonhout. Via @adamcifu 🙏 https://t.co/WTEbmSqeZ9
sensible-med.com
The reality of work-life balance in medicine is that it's often no balance at all.
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Patents, Convenience, and the future of cancer care. Always nice to write for @Sensible__Med
sensible-med.com
Every penny spent sustaining ultra-high-priced branded therapy is a penny not spent elsewhere in the health system—on earlier diagnosis, surgery, radiotherapy capacity, nursing staff, or access to...
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@adamcifu @Sensible__Med I'll have to listen later but it's great to see Dr. Bauchner. His interviews early in the COVID pandemic were invaluable and his canceling by DEI was tragic. I actually emailed him at the time and got a polite, careful response that I greatly appreciated.
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A busy day @Sensible__Med today. This Fortnight in Medicine podcast and this article by Howard Bauchner and Frederick Rivara https://t.co/SWV4foEv6Q
sensible-med.com
The third in a series of articles considering the challenge of ensuring the integrity of biomedical research.
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Need to reiterate a tenet of Medicine: Preventive treatments given to healthy people should always pass the highest evidentiary bar. This is not controversial. It’s EBM 101
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This is a small window into the rot of the modern biomedical system. This NPR segment gets it completely backwards. We’re told that a breast cancer researcher at Harvard is losing a third of her staff because of funding cuts. What the story doesn’t say: she is 76 years old,
npr.org
Amid NIH funding delays, clawbacks and uncertainty, a scientist at Harvard who studies breast cancer has lost one third of her lab employees and wonders if she can continue her research experiments.
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COVID exposed the rot at FDA. We have vaccine regulators who neglected to report dead kids and who are mutinous at the idea of stricter standards. And most FDA reporters are all too eager to help with the coverup. https://t.co/io5e8FcyvL
dailycaller.com
A top FDA official called for staff introspection, the DCNF found, following a report that the deaths of children may be attributed to the COVID-19 vaccine.
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So let me get this straight... Internal FDA results leaked before intended for public consumption which are not immediately backed by a full public report is a coverup But... years of echoing biotech/pharma press releases prior to data is "journalism"?
Seems like Vinay Prasad is the FDA person delaying the release of the case files on the alleged patient deaths. Maybe someone will need to subpoena him to disclose. Whatever happened to the FDA’s policy of “radical transparency”?
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v1.0 no myocarditis from vax (debate is evil!) v2.0 vax myocarditis is always benign (disagreement is murder!!) v3.0 vax myocarditis is less bad than C19 (nuance means death!!!) ... <@VPrasadMDMPH led @US_FDA CBER does a proper study which raises important concerns> <sends
Seems like Vinay Prasad is the FDA person delaying the release of the case files on the alleged patient deaths. Maybe someone will need to subpoena him to disclose. Whatever happened to the FDA’s policy of “radical transparency”?
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Prasad is a prolific clinical researcher , a clinical practicing oncologist and an epidemiologist who quickly climbed the ladder of academia publishing papers about pharmaceutical industry gamesmanship and spoke about regulatory capture frequently. This made him very popular
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Imagine a scenario where all leaders in gov’t had this high level of clarity of thought. It would be like Denmark The ONLY way to restore trust in public health and regulation is this approach The old way shredded trust. If you are a vaccine proponent you should applaud this
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The massive asymmetry of therapeutic bias in favor of vaccines in a nutshell: Claims of vaccine injury require proof beyond a shadow of a doubt, while therapeutic claims can be made based on antibody studies in 8 mice, immunobridging, mathematical modeling, and expert opinion.
This is totally reckless. Vaccine safety claims require verified diagnoses, clear methods, rates per million doses, and rigorous assessment of confounders. This memo provides none of that. Whatever happened to showing your work before making causal claims this strong?
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NEWS: An internal FDA review found at least 10 children died following the COVID vaccine. FDA Chief Medical Officer Vinay Prasad is calling for introspection, humility and reform at FDA in light of the finding. "For the first time, the US FDA will acknowledge that COVID-19
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@drjohnm Whether it's a peer reviewed paper, Sensible Medicine post, or leaked email... I like reading VP.
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Vinay should just post his CBER emails to his Substack and send his “team” a link. Gosh. Can his “team” not wait a day before leaking internal emails? I look forward to the details of the investigation—though it’s a bit late.
NEWS: An internal FDA review found at least 10 children died following the COVID vaccine. FDA Chief Medical Officer Vinay Prasad is calling for introspection, humility and reform at FDA in light of the finding. "For the first time, the US FDA will acknowledge that COVID-19
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