Srujana Samhita Yadavalli
@ScarletSam
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Assistant Professor of Genetics @Waksman_Inst @RutgersU| Co-admin for “Small Proteins Big Questions” slack group #newPI #parentofatoddler
Piscataway, NJ
Joined January 2009
🧵 Exciting new findings on bacterial stress response regulation, driven by small proteins (≤50 amino acids). Big shoutout to the amazing team behind this work led by @vsangeev. Read the full study here:
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RT @AnuKhareLab: Check out this new review from our lab @NCIResearchCtr, led by postdoc @kptsilva ! We explore the varied mechanisms by whi….
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Thank you @JournalSpectrum for this recognition!.
As part of #PeerReviewWeek2024 we would like to thank our top Reviewing Editors. @PMMabx @SaritaM_AIIMS @NCState_PMB @UKYMedicine @HaoTan_microbio @Xinzhao_Tong @Inflammatix_Inc @ScarletSam @jkyeom
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Huge thanks to the team: @vsangeev , Junhong Sun, John Favate, Pranavi Jagadeesan, Debbie Cerda and @premal_shah .#Microbiology #StressResponse #BacterialSignaling #SmallProteins #EscherichiaColi #GeneRegulation #MagnesiumStarvation.
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6/ The implications? Our work provides new insights into the roles of small proteins in bacterial signaling and stress response, adding another layer of gene regulation.
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5/ Overexpression or deletion of specific small proteins revealed unique growth phenotypes, showing that precise regulation of these proteins is key to maintaining cellular balance during stress.
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4/ Interestingly, YoaI showed condition-specific expression, becoming highly abundant under magnesium stress but nearly undetectable under normal conditions. This suggests a highly regulated role in response to environmental changes.
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3/ Among our findings, we discovered that a small membrane protein, YoaI, acts as a **connector** between two major signaling networks, PhoR-PhoB and EnvZ-OmpR. This breakthrough advances our understanding of how cells integrate multiple stress response pathways.
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2/ Using a combination of ribosome profiling, RNA sequencing, and transcriptional reporter assays, we identified 17 small proteins with increased activity under magnesium stress. Most of these are regulated by the PhoQ-PhoP system, essential for magnesium homeostasis.
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1/ In bacteria, small proteins are emerging as key regulators of stress responses. We focused on how these proteins help cells survive magnesium limitation, a major stressor.
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RT @Aisha_Burton: Do you like small proteins? Perhaps you need a general overview of their function. If so, check out our review (@RileeZei….
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It’s RARE for 3 good things to happen the same day - 1. My student @AdeleyeSamuelA’s paper got accepted 🎉, 2. My other student @vsangeev won a poster prize 🎉, and 3. I received the 2024 Young Investigator Award at the NJ ASM Theobald Smith Society symposium 🎉 Happy Friday!
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RT @chienlab: Taking advantage of this once-in-four year opportunity to let folks know that we start reviewing for our newest faculty searc….
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RT @RileeZeinert: I’m excited to share my first postdoctoral work where we captured the first high resolution structure of the bacterial ma….
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RT @tinaliu_phd: We are currently looking for curious, motivated individuals to join our new lab @RutgersU! Retweets are appreciated. All….
sites.rutgers.edu
Contact information and location of Tina Liu's laboratory at Rutgers-New Brunswick. We are currently recruiting for multiple positions.
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Excited to share our latest preprint! We describe a bacterial moonlighting protein with independent roles in the biosynthesis of queuosine tRNA modification and regulation of cell division. This work was led by my amazing grad student @AdeleyeSamuelA.
Queuosine biosynthetic enzyme, QueE moonlights as a cell division regulator #biorxiv_micrbio.
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RT @Dr_JeremyGBird: The Biological Sciences department at the University of Delaware is hiring a new Continuing-Track teaching faculty! We….
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