Saravanabhavan Thangavel
@SaravanabhavanT
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Thangavel lab at CSCR, Vellore. Gene editing. hematopoietic stem cells. Gene therapy.
Vellore, Tamil nadu
Joined September 2021
In collaboration with @SrujanMare58687, we report “niche in a dish” system that eliminates the need for external cytokines during culture of hematopoietic stem cells for gene therapy applications. https://t.co/a1iwWYTecy
@CSCR_CMC_inStem @DBT_inStem @DBTIndia @OffCMCVellore
link.springer.com
Stem Cell Research & Therapy - Hematopoietic Stem and Progenitor Cells (HSPCs) gene therapy has shown significant progress, with commercial approval for at least four distinct haematological...
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Proper contingent at the 13th Conclave @India_Alliance 2025. Fellows: @abimaneshID, @rohan_mic, @MahasampathG, Poonguzhali B; Team Science: Arul P Lionel, @SaravanabhavanT, Mohan Kumar Murugesan @CSCR_CMC_inStem; CRC&CRTP: Respind-Net @mahesh_moorthy -among others @OffCMCVellore
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Check out our latest review article, where we dive into recent innovations in gene editing technologies. Published in Advanced Science https://t.co/s3SA1Uotu9
@CSCR_CMC_inStem @DBT_inStem @DBTIndia
#geneediting #genetherapy
advanced.onlinelibrary.wiley.com
This review article delves into the cutting-edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a...
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To introduce new medical students at @OffCMCVellore to the latest in regenerative medicine and genetic treatments @MohankumarKMur1 & @SaravanabhavanT shared insights on cell & gene therapy research highlighting breakthroughs at @CSCR_CMC_inStem @DBT_inStem @DBTIndia
#GeneTherapy
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New publication from our lab showing therapeutic dual-beneficial mutations gene editing for the gene therapy of sickle cell disease and β-thalassemia. https://t.co/YNgKOHRK8u
@DBTIndia @CSCR_CMC_inStem @DBT_inStem @OffCMCVellore @Prathibhapbc
#SickleCellDisease #GeneTherapy
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Proud moment for us at @CSCR_CMC_inStem !
The Hindu: Indian scientists develop novel gene therapy for haemophilia Department of Biotechnology #DBT, Ministry of Science and Technology, Government of India Read: https://t.co/arFeV3NnML
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Read our commentary https://t.co/gWKikjTKzW on the new findings on HSPCs from Mikkola's lab & potential improvements this can bring to the hematopoietic stem cell and gene therapy. Congratulations @Prathibhapbc
#genetherapy #stemcells @CSCR_CMC_inStem @DBT_inStem @DBTIndia
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🎊🎉Congratulation to Dr. @SrujanMare58687 for joining the editorial board of Discover Nano-SpringerLink Journal @Discover_Jrnls
#nanodiscovery #editorialship #discovernano
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Student Talk #ARR2024 Day 2 Chemical Technology Session @Prathibhapbc of @SaravanabhavanT Lab spoke on "Editing the HBG promoter in hematopoietic stem and progenitor cells through homology-directed repair for β-hemoglobinopathies treatment" + Q&A @CSCR_CMC_inStem
@DBTIndia
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#ARR2024 Day 2 Session Molecular Basis of Disease - Part III Dr Sarvanabhavan Thangavel of our vellore unit @CSCR_CMC_inStem spoke on “Gene-edited hematopoietic stem and progenitor cells for gene therapy for Beta-hemoglobinopathies” An engaging Q&A followed @DBTIndia
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Our group is hiring for JRF and technician positions to work on gene editing. Apply at https://t.co/3IsSThBiOr or contact me. Application deadline: March 25, 2024.
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Next-gen mRNA vaccine with indigenous LNPs! Congratulations @SrujanMare58687 for this beautiful work! Our contribution was to demonstrate the M2-macrophage-specific delivery of mRNAs by LNPs. @karthikvk1996. #mRNA #LNPs
@CSCR_CMC_inStem @DBT_inStem @OffCMCVellore @DBTIndia
Dendritic cell targeting SMART-lipid nanoparticles enabled mRNA vaccine elicits cross-reactive humoral responses against the omicron sub-variants https://t.co/uvGmfhbNgf
#genetherapy #celltherapy
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What a great way to start the year! Vigneshwaran @vigneshvnkt from our lab, was awarded the Sun Pharma Science Foundation's Science Scholar Award for 2023. Congratulations Vignesh! We are very proud of you! @SunPharma_Live @DBTIndia @DBT_inStem @CSCR_CMC_inStem @OffCMCVellore
We are excited to announce the winners of Sun Pharma Science Foundation’s ‘Science Scholar Awards’ 2023. We hope this recognition encourages these young minds to pursue research as a career and commit themselves towards the advancement of science. #ReachingPeopleTouchingLives
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Registration for our 8th annual cell and gene therapy symposium is now open! Important topics and a fascinating lineup of speakers!! #genetherapy #celltherapy
@CSCR_CMC_inStem @DBT_inStem
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Our work on gene editing therapy for Beta-hemoglobinopathies is on the cover of @moltherapy
#WorldSickleCellDay @DBTIndia @DBT_inStem @CSCR_CMC_inStem @redglobin @Prathibhapbc
New issue of @MolTherapy Nucleic Acids (#MTNA) out today! On the cover: A schematic illustration of a novel #geneediting strategy for #genetherapy for Beta-hemoglobinopathies. https://t.co/bMhGoLvenY
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@DimpleNotani helped us understand the LCR switching regulating the robust HbF activation post-gene editing. Lastly, we show that the editing can be achieved without cytokine pre-stimulation of the HSPCs (5/5)
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Gene editing the core region in patient hematopoietic stem cells reverses both #sicklecelldiseases #βThalassemia (4/5)
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We show large regions such as this core regulatory region can be precisely excised from the genome without hampering genome integrity or the in vivo multilineage engraftment potential of the stem cells (3/5)
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@Viggibaba identified a core region in HPFH deletions that reactivates fetal hemoglobin and ablates defective β-globin. Compared with other well-established targets such as BCL11A, the new target PRR-βE1 showed superior HbF production and ablated defective HbA production. (2/5)
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