Mohankumar K. Murugesan
@MohankumarKMur1
Followers
56
Following
6
Media
0
Statuses
17
Joined May 2018
Excited to share our publication highlighting the use of nickase-deficient base editors to overcome interstitial deletions in homologous regions .Thanks to everyone involved!. @CSCR_CMC_inStem @DBT_inStem @DBTIndia.#baseediting #CRISPR.
cell.com
Mohankumar and colleagues show that DNA nicks are the main cause for the formation of indels and large deletions while using base editors in homologous regions. They describe the use of a nickase-d...
1
1
5
Delighted to share our lab's latest paper published in Molecular Therapy Nucleic Acids on correction of various β-thalassemia mutations in coding and non-coding regions using base editors”.DOI:
0
0
0
Congratulations.@KirtiPr28942577.and the rest of the team. Thanks.@Gregory_Newby.@Shaji_Velayudh.@SrujanMare58687.@SaravanabhavanT.and others. @MolTherapy.@CRISPR_Articles.@CSCR_CMC_inStem.@DBT_inStem.@serbonline.@DBTIndia.#baseediting #CRISPR #Thalassemia #hematology.
0
0
0
Congratulations @vigneshr1292 @Nivedhitha1996 and the rest of the team. Thanks @MerlinCrossley @jcornlab @JoelPMackay @staciakwyman @SrujanMare58687 and others. @MolTherapy @CRISPR_Articles @DBTIndia @CSCR_CMC_inStem @DBT_inStem . #BCL11A #ZnFdomains #baseediting.
0
3
12
Excited to share our latest research work published on Molecular therapy. We performed a structural/function analysis of the BCL11A-XL specific ZnF domains unraveling exciting functions of the C-terminal ZnF domains of the longer isoform.
2
5
11
Pleased to share our work on the use of nickase-deficient base editors to avoid large deletions while editing the highly homologous regions such as the therapeutically relevant HBG promoters.. #baseediting #sicklecellanemia .#CRISPR #genomeediting.
biorxiv.org
Base editing in gamma-globin promoter is a promising approach for reactivation of fetal-hemoglobin. Recent studies have shown that base editing could result in genotoxic events at the gamma globin...
0
2
7
Happy to share the work from our lab done by @anilageorge10 on the correction of the sickle mutation using prime editor @CSCR_CMC_inStem @DBT_inStem @DBTIndia @HRDG_CSIR #CRISPR #sicklecelldisease #PrimeEditing #GenomeEditing.
frontiersin.org
Sickle cell anaemia (SCA) is one of the common autosomal recessive monogenic disorders, caused by a transverse point mutation (GAG>GTG) at the sixth codon of...
2
5
21
Thanks to @eLifeCommunity for this award. It would not be possible without the support from @CSCR_CMC_inStem @DBT_inStem @DBTIndia.
Kumarasamypet Mohankumar (@MohankumarKMur1) aims to develop genome-editing strategies to treat genetic blood disorders. He says the award will “help us extend our published preclinical work to in vivo models and, in turn, evaluate its potential clinical applications”.
4
3
23
RT @eLifeCommunity: Kumarasamypet Mohankumar (@MohankumarKMur1) aims to develop genome-editing strategies to treat genetic blood disorders.….
0
1
0
RT @eLifeCommunity: We’re delighted to introduce the 10 winners and two runners-up of this year’s Ben Barres Spotlight Awards! 🎉. And this….
0
11
0
RT @biorxivpreprint: Precise modelling and correction of a spectrum of β-thalassemic mutations in human erythroid cells by base editors ht….
0
2
0
RT @DBTIndia: Scientists have shed light on so far unknown regulatory elements within the HBG promoter and identified additional targets fo….
0
12
0
RT @DBT_inStem: In a recent study published in @ACSPublications , @srujannano in collaboration with @pkvemula developed a self-skin permeab….
0
4
0
Congratulations @Nithin_Sam91, @ANILAGEORGE10 @Nivedhitha1996, and others. Special thanks to.@BeekeWienert .@staciakwyman .@HenryWBell .@SaravanabhavanT .@srujannano .@DBT_inStem .@OffCMCVellore .@DBTIndia .@INDOUSSTF.
0
0
0
Excited to share the first manuscript from our lab in collaboration with @jcornlab, @MerlinCrossley, and colleagues @CSCR_CMC_inStem. #baseediting #CRISPR #SickleCell .
elifesciences.org
Adenine and cytosine base editing of highly homologous HBG proximal promoter identifies novel target sites that result in adult to fetal globin switching without causing 4.9 kb large deletions.
1
0
5
RT @MerlinCrossley: Great to have contributed to this paper on using #CRISPR base editing to boost fetal hemoglobin to treat #SickleCellDis….
elifesciences.org
Adenine and cytosine base editing of highly homologous HBG proximal promoter identifies novel target sites that result in adult to fetal globin switching without causing 4.9 kb large deletions.
0
5
0