Salic Lab
@Salic_Lab
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Lab of Adrian Salic @harvardmed @HarvardCellBio Our lab studies how vertebrate cells send and respond to Hedgehog signals #hedgehog 🦔 #cilia
Boston, MA
Joined March 2018
Congratulations Hui-Ting!
Our structure of thee BBSome is out: https://t.co/vOu0ZjH0uh. We find evidence of a conformational change upon recruitment to membranes. Fantastic collaboration with Tom Walz, special thanks to Hui-TIng Chou who kept working on this project for 6+ years.
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Rest In Peace.
We are at a loss of words. May she rest in peace. Our thoughts are with her family, friends and colleagues. Let us remember SUZANNE as the phenomenal thinker, mother and human being she was... https://t.co/9lKmmcdSlP
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Please share this message to anyone in #cretegreece or surrounding regions https://t.co/gnrpxcAv3p
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Please RT/share! 🙏.
With a heavy heart we have to inform you that SUZANNE is missing from her hotel @orth_acad_crete since Tuesday. She was attending a meeting in Kolymbari, Crete. Search is on in full swing. Please spread this to reliable networks and PRAY for her safe return.(1/2)
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More exciting news! Former postdoc Long Li has struck out on his own with great success! Here’s his first #cryoEM structure: a complex of SecA and SecY translocating a polypeptide chain substrate. https://t.co/oTQAtnLVwX
nature.com
Nature Communications - Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the...
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We’re thrilled to share the #CryoEM structure of the Cdc48-UN complex bound to and unfolding a polyubiquitinated substrate! Cdc48 first unfolds a K48-linked ubiquitin moiety allowing the processing of diverse substrates. Congrats to Zhejian and @cryoET! https://t.co/hXmQybyaYc
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A very comprehensive review! #hedgehog 🦔
A review from our own Jenn Kong on biochemical mechanisms of Hedgehog signaling, written with Christian Siebold, is out in Development-- includes an analysis of the many patched and smoothened structures. @Dev_journal
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A fully referenced guide to making your lab more nurturing, collaborative and people-centred, courtesy of @ftmaestre.
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Baby Smo blossoms, Now the spring is here to stay, When will petals fall? #happystpatricksday #BostonMarathon #BostonStrong
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Congratulations!
A big congratulation to Prof Stephen Harrison who will receive Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research "for his fundamental and far-reaching studies of protein structure using X-ray crystallography" tonight during an award ceremony at @BrandeisU
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Team Steptonemes taking on the Take the Stairs challenge @HarvardChanSPH. @kornberg_t look closely!
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Congratulations, Marco!
We're excited to share the newest research from our lab! In collaboration with @JoeLoparo, we use smFRET to observe the conformational changes of the AAA ATPase SecA as it translocates a model substrate through the SecY channel. https://t.co/kY2D6F4VIE
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On #InternationalWomensDay, we’re celebrating women in the Harvard Medical School community who are making a difference in the world
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Team Cytomeme at the Cell Bio tri lab trivia night, with @RapoportLab and Liberles lab #TriviaNight
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