Sebastian Duno-Miranda 🔬
@SDuno_Miranda
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PhD candidate @UVMLarnerMed. Multi-scale Physiology & Biophysics. Applied Machine Learning.
USA
Joined July 2018
Paper is out! This was an immense team effort between the Yengo lab @smlbodt , Sivaramakrishnan lab @DuhaVang and the Warshaw lab.
.@SDuno_Miranda, Warshaw et al. @uvmvermont investigate the E525K mutation in human β-cardiac myosin, a protein crucial for heart contraction, and its role in causing dilated cardiomyopathy (DCM). #CardiacMuscle #Contraction #CellMotility
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College/Grad student most annoying nightmare. act 1: you write your thesis, then you realize your table of contents’ numbers are not aligned. act 2: no easy way to format a table of contents (unbelievable right?). >For all students out there, I built a simple and open source web
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Discover more about this study: What’s the wildest secret your heart holds? Reply below!.
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Unlike skeletal muscle, your heart’s motors seem to cooperate like a train crew that never stops. Understanding how they communicate is crucial to unlock molecular mechanisms of heart disease and develop targeted therapies.
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These stripes are full of tiny motors that arrange in filaments, like a long train with areas to sleep, dine, or store luggage. They even ‘communicate’ with each other while they keep your heart beating!
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The three stripes you didn’t know you had inside your heart. Mysterious enough to have code names: P, C, and D. 🫀.
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Research spotlight 🚨 - Mishaps of a Human Mutation Inside a Pig Heart. The study "Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants" by Flisikowska, Petersen, Mearini, Huber, Kurome, Stoff, Schlossarek, Lucas-Hahn, Wolf,.
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From the Lab 🚨 Half the function, full therapeutic benefit?. A few months ago, I was given a presentation about cardiac molecular motors. (full study here: a collaborative effort between the Warshaw Lab, Yengo Lab and Sivaramakrishnan Lab). Right after
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Research spotlight 🚨. Can we see the inside of the heart muscle while is working?. Sort-of. The study "Annotating the X-ray diffraction pattern of vertebrate striated muscle" by Koubassova, Dutta, Ma, Tsaturyan, Irving, Padrón, and Craig.doi:
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Research spotlight 🚨 - Is Your Heart Too Stiff?. The study "Direction‑dependent contributions of cardiac myofilament networks to myocardial passive stiffness reveal a major disparity for titin" by .Wagner, Loescher, Unger, Kühn, Klotz, Liashkovich, Ciechanska, Schillers,.
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From bench to beside 🚨 - A Summary that Captivates. Authors Maron, Olivotto, and van Sinttruije captured my attention with their plain language summary of the SEQUOIA-HCM study: aficamten for symptomatic obstructive hypertrophic cardiomyopathy.
tandfonline.com
Published in Future Cardiology (Vol. 21, No. 7, 2025)
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RT @EU_METAHEART: 📃📣 📣📣September news!.➡️Great success for our 1st Training School in Wurzburg on @OroborosI, Seahorse & @IonOptix with 1….
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@manorlaboratory Intuition: imagine recognizing a soda bottle looking at the cap from above(2D), and you want to capture the boundaries of the whole bottle(3D). Doesn't matter if the bottle is pear shaped or hourglass shaped, as long as you know how to follow the contour, you'll solve the shape.
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Clever use of Machine Learning addressing 3D biological data segmentation from @manorlaboratory. Essentially, if you know what to look for in 2D, you can teach a model to approximate its depth, irrespective of the nature of the depth data. (1/2)
biorxiv.org
Producing dense 3D reconstructions from biological imaging data is a challenging instance segmentation task that requires significant ground-truth training data for effective and accurate deep...
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Our study on Human Cardiac Myosin Molecular Mechanics got the JGenPhysiol June 2024 cover image! Credits to all co-authors, with special mention of the Warshaw lab mentoring team.
Our June issue is out Human cardiac myosin molecular motors power the heart by moving actin. The cover shows myosin, surface-attached by their green fluorescent protein tails, propelling actin. From @SDuno_Miranda et al. (
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Interesting preprint from the Warshaw lab: Deciphering the role of Myosin-binding protein H!.
Functional role of myosin-binding protein H in thick filaments of developing vertebrate fast-twitch skeletal muscle #bioRxiv.
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RT @ThePunihaoleLab: Excited to announce our lab's second paper, published today in @JChemPhys (. It's our foray i….
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RT @OsamaHarraz: The final version of our @physiolrev editorial is published!. Ion channel dysfunction is a hallmark for many diseases. Sin….
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"Study of the mechanism of activation by cooperative phosphorylation of tarantula muscle contraction". Pleasantly surprised to have found that my licentiate thesis (pdf), under supervision of @raulpadron , with special mention of @bolanosp, Lorenzo Alamo, Gustavo Marques, Antonio.
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