RuijterLab
@RuijterLab
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Dedicated to the development of creative methods for the synthesis of complex molecules
Amsterdam, The Netherlands
Joined March 2021
Woke up at 5:45 this morning😴, but it was totally worth it!😊 Had a blast sharing some sugar-sweet chemistry at the @HRSMC1 symposium and loved all the insightful talks!🍬🍫 Great to see this community together!🎉
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Now as early view @angew_chem: Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin https://t.co/In76ih4Xvy Big congrats to first author @YesteAlejandro & thanks to our great collaborators @Al_rebreG @maric_hans @SchulteClemens #peptidomimetics
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Out now @angew_chem: Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene β-Catenin https://t.co/In76ih4Xvy Big congratulations to first author @YesteAlejandro and thanks to the great collaboration partners @Al_rebreG @maric_hans @SchulteClemens
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@PascalVermeeren wins KNCV-CTC Thesis Award🏆! Well done Pascal! 🎉 @KNCVchemie @VU_TheoCheM @VU_Science.
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The final version is now out in @ChemEurJ Early View! Read it here: https://t.co/LiRHI62SUF
Do you think the Ugi multicomponent reaction: - is only useful for boring small molecules? - does not work with hindered ketimines? - has poor diastereoselectivity? Then read our latest work (Open Access!), just out as Acceped Article in @ChemEurJ:
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Are you coming to the 2024 Dutch Peptide Symposium, May 31 at VU Amsterdam O2 auditorium? We have some exciting invited speakers confirmed, and now we need you! Registration is open until 20 May, abstracts until 1 May, all on https://t.co/7rhuOf0CMs
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Our recent paper in @ChemEurJ on iron-catalyzed carbene transfer to isocyanides attracted significant attention from the chemistry community and is now a #TopDownloadedArticle! Read it yourself (Open Access!):
chemistry-europe.onlinelibrary.wiley.com
The readily available low-valent iron complex [Fe(CO)3NO]− catalyzes the efficient transfer of carbenes to isocyanides. The resulting ketenimines undergo in situ cyclocondensation with various...
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Now online: Transcription factor-targeting stapled peptides @ChemBioChem We've captured 2 peptide confirmations with crystal structures & used MD simulations to understand the dynamics https://t.co/w7ofx1pjD8 Congrats @Canan_Durukann @ioana_ilie_UvA @jocelyne_vreede @VU_Science
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The reaction proceeds with complete diastereoselectivity. DFT studies not only provided insight in the origin of stereoselectivity, but also showed that the reaction proceeds through a hydrogen bonding mechanism, resembling the accepted mechanism of the Passerini reaction.
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We use an intermediate from our recent total synthesis of monoterpene indole alkaloids as the imine input in a three-component Ugi reaction to gain rapid access to diverse, highly functionalized 'synthetic alkaloids'. @brendan_horst @THansenChem
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Do you think the Ugi multicomponent reaction: - is only useful for boring small molecules? - does not work with hindered ketimines? - has poor diastereoselectivity? Then read our latest work (Open Access!), just out as Acceped Article in @ChemEurJ:
chemistry-europe.onlinelibrary.wiley.com
A complex pentacyclic ketimine undergoes a fully diastereoselective Ugi-type multicomponent reaction with various isocyanides and carboxylic acids to give a range of non-natural indole alkaloid...
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Petasis three-component reaction without the classic restriction on the aldehyde input: great work! The scope of accessible branched tertiary amines is amazing!
Now you can Petasis (virtually) any borons! Super simple and powerful method to prep fully-sp3 complex amines is now on @ChemRxiv as our collaborative work with @QinLab. Congrats on everyone's accomplishment! @JetTsien @SijieChen17 @rohanmerchant1
https://t.co/3jWQFiOJ0Y
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Very proud of this work! 🔥 In 2021, our work on understanding H2 activation by metallylenes appeared in @ChemicalScience ( https://t.co/QvHF29SK1L). Now we close the cycle and report how these metallylenes can potentially catalyze hydrogenation reactions in @EurJOC!⬇️
pubs.rsc.org
We have studied the activation of dihydrogen by metallylenes using relativistic density functional theory (DFT). Our detailed activation strain and Kohn–Sham molecular orbital analyses have quantif...
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Less than a week left until the Early Bird deadline, so register now for the 2024 Dutch Symposium on Organic Chemistry! Also, note a small update in our speaker line-up (see flyer). Register here: https://t.co/BTDqNmpvEu More info: https://t.co/tl3TBVjT1d
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What a team effort it was, and the end result just blew our minds. If you want to know the story behind #RoboChem, check our blog article: https://t.co/h4qwj3fz0s I promise you there are some funny passages, drama and a happy ending with its publication today in @ScienceMagazine
noelresearchgroup.com
When I embarked on my independent academic career, my mission was clear: to push the boundaries of synthetic organic chemistry through technological innovation. One of my most audacious dreams was to...
We're absolutely thrilled that our robotic platform, #RoboChem, has been published in @ScienceMagazine! 🔗 https://t.co/r2aH05fcV6
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every single entry. 🤖 #FlowChemistry #photocatalysis
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Don't miss F. Matthias Bickelhaupt's et al.'s recent article - it's one of this week's #ChemSciCovers Nature and strength of group-14 A–A′ bonds 🔗 DOI https://doi.org/10.1039/D3SC06215E
@Daniela_R_Silva @EvaBlokker @TrevorAHamlin @fmbickelhaupt @VU_TheoCheM
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Join us in Lunteren at the biannual Dutch Symposium on Organic Chemistry - April 4-5, 2024! @soc_kncv invites you to two days of exciting developments in organic chemistry! Register here: https://t.co/BTDqNmpvEu More info: https://t.co/tl3TBVjT1d
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We're absolutely thrilled that our robotic platform, #RoboChem, has been published in @ScienceMagazine! 🔗 https://t.co/r2aH05fcV6
#RoboChem can carry out your substrate scope and provide tailored reaction conditions for every single entry. 🤖 #FlowChemistry #photocatalysis
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One way or another!🍎↔️🍐 We explain in our new @JOC_OL how minimal changes in the donor impact the formation of different reactive intermediates and stereoselectivity!💥 Great Leiden-A'dam-Nijmegen team work!🤜🤛 @WA_Remmerswaal @HiddeElferink 🗞️▶️ https://t.co/wFpTeWamJg
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Our #OpenAccess paper on the Blueshift in Trifurcated Hydrogen Bonds was featured on the cover of @ChemPhysChem! 🔥 Cover: https://t.co/NnbegSinej Paper: https://t.co/zVndLaMdhP
@LucasAzdS Storm Shiri @CeliaFGuerra @fmbickelhaupt @VUamsterdam
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