Davide Ruggero
@RuggeroDavide
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UCSF Diller Cancer Center
Joined May 2016
A fascinating connection between translation decoding specificity through metabolites that help cells control a vital redox state. Congrats Josh @Mendell_lab and Fred!!
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story led by Frederick Rehfeld revealing that the answer is YES! Read on to find out how.
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Try the Rapidash protocol to isolate ribosomes from any sample in less than 5 hours. At the moment, the best protocol to characterize ribosome associated proteins (RAPs) by MS without contamination from other multi-protein complex components!
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Online Now: Ribosomal rebellion: When protein factories drive cancer progression https://t.co/DgHxiqvTvn
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Thanks Levi Gadye and Laura Kurtzman for the thoughtful and creative press release! @UCSF @UCSFCancer
“Zotatifin, as a bona-fide ‘translatome therapy’ that blocks the production of cancer-causing proteins, expands the landscape of drugs available for patients,” @DuyguKuzuoglu on latest research w/ @haognguyen @RuggeroDavide @kevansf @ucsf
https://t.co/JPbEYAqax6
#PCSM
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And we couldn't make it without @PCFnews @pcarroll_ and Benioff Initiative for Prostate Cancer Research support! https://t.co/RGH6wZqkLl
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Happy to share our new work with @haognguyen on targeting mRNA translation of oncogenes by RNA structure remodeling with a small molecule zotatifin. Congrats to @DuyguKuzuoglu an amazing postdoc and all the authors and collaborators! https://t.co/RGH6wZqkLl
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Great tools and tips for the field to study IRES-dependent translation. Beautiful dissection of true HOX IRES translation in developing embryos. Congrats to all @mbarnalab @KatLeppek!
A powerful toolbox to study IRES activity highlights the IRES-dependent translation of HOX mRNAs in a cell and tissue specific manner .
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A tour de force in deciphering in action the intriguing dynamic composition of ribosomes in vivo. Beautiful work! Congrats to all @mbarnalab!
Very proud of my graduate students @adelefrancisxu and Zijian Zhang & key members of our lab and collaborators @GarryPNolan & Sharon Pitteri lfor the incredibly hard work to characterize subcellular ribosomes.
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Thanks Levi Gadye, for the wonderful and insightful highlight of our last publication! @UCSF
https://t.co/mQtyA7yCS6
ucsf.edu
UCSF scientists discover how cancer cells hijack the protein factory of the cell to churn out MYC protein, the driver of 70% of all cancers.
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Thanks to the authors and collaborators @rushika_perera lab. Thanks @ACS_Research @NCICancerBio for the support. @UCSFUrology @UCSFCancer
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Very proud of @ScientistJoanna for uncovering a new selective regulator of MYC mRNA translation and its implication in pancreatic cancer! She is on the job market, so keep an eye on her! She is terrific!
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Congrats @mbarnalab @travisclantz and Christine on this award and making progress on targeting ribosomes to increase protein synthesis!
Very grateful for the support from @pewhealth for this project and @travisclantz who is an amazing graduate student who is taking the lead on getting this project off the ground!
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Congrats on this beautiful paper on another great link between lipid metabolism and translation control! @DeSiqueiraMK, @ClaudioVillanu, and team!
Excited to share our latest work in @CellReports highlighting a PPARγ-dependent remodeling of translation machinery in adipose progenitors. Amazing collab between our lab @ClaudioVillanu @YangLabUCLA and @LauraHulea
@CellPressNews @uclaibp
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Amazing work on uncovering a new role for tRNAs in linking mRNA stability with codon-specific translation! Congrats @Mendell_lab and team!!
I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. https://t.co/gXsJo1Mc1B
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Amazing paper on specialized ribosomes and their roles in cancer immune response! Congrats @liamfaller and all team!
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Thanks @RNACanadaC2R2 for organizing an amazing RNA meeting!
Davide Ruggero characterized the structure of Myv 5’UTR and a key RNA binding protein that regulates its translation level by interacting with specific structural motifs. Cool work
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Maria Barna (Stanford University) on “Ribosomes in Gene Regulation: Controlling the diversity of proteins made in specific cells, tissues and organisms” #RNACanadaARN
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